Haw leaf total flavone oral disintegration tablet and its preparing method

A technology for oral disintegrating tablets and total flavonoids, which is applied in the directions of pharmaceutical formulations, medical preparations containing active ingredients, and pill delivery, etc., can solve the problems of difficulty in swallowing, slow dissolution of oral dosage forms, low bioavailability, etc., and achieves convenient administration. , good disintegration performance and high bioavailability

Inactive Publication Date: 2005-01-12
CHENGDU SHENGNUO BIOTEC CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to solve the problems of slow dissolution, low bioavailability and difficulty in swallowing of the above-mentioned oral dosage forms, and provide a kind of orally disintegrating tablet of total flavonoids of hawthorn leaves that can disintegrate, release and mask bad taste and its preparation method, thereby To achieve the purpose of improving the ease of use and convenience of oral preparations of total flavonoids from hawthorn leaves

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Example 1: Preparation of hawthorn leaf total flavonoids by percolation method

[0040] Take the hawthorn leaves, pulverize them into coarse powder, add ethanol to evenly moisten it and place it in a sealed container, then put it into the percolator, add ethanol to the surface of the medicinal material soaked, immerse it for 2 to 3 hours, then carry out percolation, collect the liquid, reduce Press to recover ethanol to a certain concentration, add the same amount of water to dilute, add petroleum ether to remove the pigment, separate the water layer, shake and extract with ethyl acetate, the extract is decompressed to recover ethyl acetate and concentrate to dryness to obtain total flavonoids. The total flavonoid content is greater than 80%.

Embodiment 2

[0041] Example 2: Preparation of Hawthorn Leaf Total Flavonoids Extract by Water Extraction and Alcohol Precipitation

[0042] Take the hawthorn leaves, pulverize, add 5 times the amount of water, 0.4-0.6% alkali solution, heat at 70-90°C and stir slowly, and extract 3 times. The extracts were combined and concentrated under reduced pressure. After the concentrated solution is cooled, add 95% ethanol to 60-80% alcohol content. After refrigerating and standing for filtration, the filtrate is distilled to recover ethanol, diluted with water, standing for filtration, and the filtrate is shaken and extracted with ethyl acetate. The extract is The ethyl acetate was recovered under reduced pressure and concentrated to dryness to obtain total flavonoids. The total flavonoid content is greater than 80%.

Embodiment 3

[0043] Example 3: Preparation of hawthorn leaf total flavonoids extract by resin adsorption extraction method

[0044] Take hawthorn leaves, crush them into coarse powder, extract with hot water or ethanol, concentrate the extract to dryness under reduced pressure, add water and stir, stand for filtration, and filter the filtrate through a macroporous adsorption resin column, eluting with ethanol, and recovering ethanol under reduced pressure , Concentrated to dryness, to get total flavonoids. The total flavonoid content is greater than 90%.

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PUM

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Abstract

An oral disintegrating tablet of the common flavone of haw leaf is prepared from said common flavone, filler, disintegrant, effervescent agent, lubricant and flavouring through proportionally mixing, and die pressing.

Description

Technical field: [0001] The invention relates to an orally disintegrating tablet of hawthorn leaf total flavonoids, which can rapidly disintegrate and release medicines in the oral cavity, which has the functions of promoting blood circulation, removing blood stasis, promoting heart circulation, regulating qi and relaxing collaterals. The invention also relates to a preparation method of the preparation. Background technique: [0002] Different varieties of hawthorn leaves are rich in flavonoids and other biologically active ingredients. The flavonoids extracted from the leaves of hawthorn are collectively called the total flavonoids of hawthorn leaves. More than 30 kinds of monomers have been separated from them, and the preparation is called "Yixinone". Years of studies have shown that the flavonoids in hawthorn leaves have various pharmacological effects and have good application prospects for the prevention and treatment of cardiovascular diseases. [0003] At present, the or...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/7048A61P9/10
Inventor 谢期林
Owner CHENGDU SHENGNUO BIOTEC CO LTD
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