Orally disintegrating tablet of meloxicam and its preparation

Abstract

The invention discloses a meloxicam orally disintegrating tablet. The main drug is meloxicam, and the auxiliary materials include lactose, mannitol, microcrystalline cellulose, low-substituted hydroxypropyl cellulose, cross-linked polyvinylpyrrolidone, Sodium bicarbonate, citric acid, aspartame, essence, magnesium stearate, the present invention has good therapeutic effect to rheumatoid arthritis, painful osteoarthritis, and convenient to take, can disintegrate rapidly, give some It provides convenience for the elderly, infants and children, or those who have difficulty swallowing medicines, or patients who have trouble getting water.

Description

Technical field: [0001] The invention relates to an oral pharmaceutical preparation for treating rheumatoid arthritis and painful osteoarthritis and a preparation method thereof, in particular to a meloxicam orally disintegrating tablet that can rapidly disintegrate, release and mask bad taste and its preparation method. Background technique: [0002] In the prior art, clinical studies have shown that meloxicam has strong anti-inflammatory activity, better gastrointestinal and renal tolerance than other NSAIDS, and can effectively treat rheumatoid arthritis (RA) and osteoarthritis. Arthritis (OA). [0003] At present, although meloxicam is available in various oral dosage forms, it is not very convenient for the elderly and children who have some difficulty swallowing. For example: In the case of tablets and capsules that are commonly used in oral formulations, many elderly and children with poor swallowing abilities are reluctant to take these solid dosage forms and compl...

AI Technical Summary

Problems solved by technology

[0003] At present, although meloxicam has various oral dosage forms, it is not very convenient for the elderly and children who have difficulty swallowing

For example: In the case of tablets and capsules commonly used as oral preparations, many elderly people and children with poor swallowing ability are reluctant to take these solid dosage forms, complaining of difficulty swallowing medicine or esophageal obstruction, while chewable tablets are also It is also not suitable for the elderly and children with weak chewing ability

As far as powders or granules are concerned, in addition to their difficulty in swallowing, they are also easy to stay in the mouth, resulting in an unpleasant feeling in the mouth. At the same time, drinking water is required when taking the above oral preparations, especially the elderly and children need to take a lot of water However, drinking too much water will affect the night rest of the elderly and children

Syrups are considered an ideal dosage form for the elderly and children, but for many elderly and infirm patients who are still unable to deliver liquid preparations into their own mouths, these dosage forms cannot be considered suitable for the elderly and infirm due to the difficulties in taking the medication. The most suitable dosage form for children

In addition, the bitter taste and bad smell of many oral medicines are often unacceptable, causing some patients to refuse treatment in order to avoid taking the medicine, delaying the best time for treatment

Images