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Combination of tablet to swallow of containing Cetirizine Hydrochloride

A technology of cetirizine hydrochloride and its composition, which is applied in the field of pharmaceutical preparations, can solve problems affecting patients' mood and medication compliance, and parents of children with difficulties in taking medication, etc., and achieve the goals of improving compliance, taking it conveniently, and improving the taste Effect

Inactive Publication Date: 2005-08-31
LUNAN PHARMA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] However, because cetirizine has a very severe bitter taste, it will be developed into an orally disintegrating tablet or an oral liquid preparation that disintegrates rapidly in the oral cavity, which will greatly affect the patient's medication mood and medication compliance, especially For infants and young children, the difficulty of taking medicines has always been a difficult problem for the parents of the children.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Cetirizine Hydrochloride 2g

[0019] β-cyclodextrin 10g

[0020] Mannitol 60g

[0021] Low-substituted hydroxypropyl cellulose 10g

[0022] Aspartame 0.5g

[0023] Appropriate amount of distilled water

[0024] Talc powder 0.5g

[0025] Preparation Process:

[0026] The main drug is passed through a 120-mesh sieve and dissolved in β-cyclodextrin in hot water at 60-80°C, kept for more than 60 minutes, cooled, β-cyclodextrin precipitates, filtered, dried, and sieved; cross-linked polyvinylpyrrolidone, albino Pass the spartame through a 100-mesh sieve, weigh according to the prescribed amount, mix evenly, add appropriate amount of distilled water, granulate, dry, granulate, add the prescribed amount of talcum powder, mix evenly, and press into tablets.

Embodiment 2

[0028] Cetirizine Hydrochloride 5g

[0029] Dimethyl β-cyclodextrin 20g

[0030] Lactose 50g

[0031] Cross-linked sodium carboxymethyl starch 20g

[0032] Peppermint essence 1g

[0033] Appropriate amount of distilled water

[0034] Magnesium stearate 0.5g

[0035] Preparation Process:

[0036] Pass the main ingredient through a 120-mesh sieve and dimethyl β-cyclodextrin, grind and mix well, pass through a 100-mesh sieve for lactose, cross-linked sodium carboxymethyl starch, and mint essence, weigh according to the prescription, mix well, and add an appropriate amount of distilled water , granulated, dried, granulated, added with prescribed amount of magnesium stearate, mixed evenly, and compressed into tablets.

Embodiment 3

[0038] Cetirizine Hydrochloride 15g

[0039] Hydroxypropyl beta-cyclodextrin 80g

[0040] Mannitol 90g

[0041] Sodium carboxymethyl starch 15g

[0042] Lemon essence 1g

[0043] Appropriate amount of distilled water

[0044] Magnesium Stearate 1g

[0045] Preparation Process:

[0046] With embodiment 2, the lemon essence in the present embodiment also can be replaced with chocolate essence.

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PUM

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Abstract

An orally-taken composite medicine containing cetirizine hydrochloride is prepared from cetirizine hydrochloride, cyclodextrin or its derivative, and flavouring. It features its agreeable taste.

Description

technical field [0001] The invention belongs to the technology of pharmaceutical preparations. Background technique [0002] In recent years, due to climate and environmental changes, various harmful gases, dust and other pollution sources have emerged in large numbers, making them allergens that cause people to have various allergic reactions. Seasonal changes, field work, pollen allergies, inhalation of harmful gases and dust particles, etc., have caused more and more people to suffer from various types of allergic diseases, such as allergic rhinitis, urticaria, skin redness, itching, rashes, etc. Red spots and asthma caused by allergens are very common. Therefore, it is very important to pay attention to environmental changes, strengthen self-care, and develop drugs for the treatment of allergies. [0003] At present, antihistamines are mainly used in the treatment of allergic diseases, mainly including cetirizine, terfenadine, astemizole, loratadine, avastin, levocabas...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/495A61P37/08
Inventor 赵志全
Owner LUNAN PHARMA GROUP CORPORATION
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