Preparation method of multiple drug fiber membrane for reducing foreign body reaction of implant material

An implant material and fibrous membrane technology is applied in the field of preparation of multi-drug fibrous membranes, which can solve the problems of difficulty in delaying and controlling drug release, difficult control of drug toxicity, and insufficient drug efficacy, so as to achieve inhibition of bacterial reproduction, Good biocompatibility, preventing rapid release

Inactive Publication Date: 2018-03-13
WUXI ZHONGKE GUANGYUAN BIOMATERIALS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the process of drug release, traditional drug coatings are difficult to delay and control drug release, and there are problems such as insufficient drug efficacy, poor stability, and difficult to control drug toxicity.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] (1) Dissolve ampicillin in water to obtain an antibiotic aqueous solution with a mass volume concentration of 15% (w / v), then dissolve polyethylene glycol (PEG) in the antibiotic aqueous solution, and stir uniformly to obtain a GE mass volume concentration of 20 % Of the core layer electrospinning solution.

[0026] (2) Dissolve the foreign body giant cell formation inhibitor Bay 11-7082 in DMSO to obtain an inhibitor solution with a mass volume concentration of 12%, and then dissolve polylactic acid in the DMF / dichloromethane mixture to prepare a mass volume concentration For 30% spinning solution, the above spinning solution and inhibitor solution are mixed in a volume ratio of 10:1 to obtain a skin layer electrostatic spinning solution.

[0027] (3) The skin layer electrospinning solution and the core layer electrospinning solution are respectively put into the syringe, and the coaxial electrospinning device is used for coaxial electrospinning to obtain a nanofiber membra...

Embodiment 2

[0032] (1) Dissolve cefixime in water to obtain an antibiotic aqueous solution with a mass and volume concentration of 20%, then dissolve gelatin (GE) in the antibiotic aqueous solution, and stir uniformly to obtain a core layer electrospinning with a GE mass and volume concentration of 20% Solution.

[0033] (2) Dissolve the foreign body giant cell formation inhibitor Bay 11-7082 in DMSO to obtain an inhibitor solution with a mass volume concentration of 15%, and then dissolve polyethylene glycol (PEG) in the DMF / dichloromethane mixture A spinning solution with a mass volume concentration of 50% is prepared, and the spinning solution and the inhibitor solution are mixed in a volume ratio of 10:1 to obtain a skin layer electrostatic spinning solution.

[0034] (3) The skin layer electrospinning solution and the core layer electrospinning solution are respectively put into the syringe, and the coaxial electrospinning device is used for coaxial electrospinning to obtain a nanofiber m...

Embodiment 3

[0039] (1) Dissolve cefixime in water to obtain an antibiotic aqueous solution with a mass volume concentration of 10%, then dissolve hyaluronic acid (HA) in the antibiotic aqueous solution, and stir uniformly to obtain a core layer static electricity with a GE mass volume concentration of 20% Spinning solution.

[0040] (2) Dissolve the foreign body giant cell formation inhibitor Bay 11-7082 in DMSO to obtain an inhibitor solution with a mass volume concentration of 10%, and then dissolve polycaprolactone in the DMF / dichloromethane mixture to prepare a mass The spinning solution with a volume concentration of 20% is mixed with the inhibitor solution in a volume ratio of 10:1 to obtain a skin layer electrostatic spinning solution.

[0041] (3) Put the skin layer electrospinning solution and the core layer electrospinning solution into a syringe respectively, and use a coaxial electrospinning device to perform coaxial electrospinning to obtain a nanofiber membrane with a "skin-core"...

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PUM

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Abstract

The invention belongs to the field of biological materials. A medical implant material can generate a foreign body reaction when entering a human body, and a present, a drug coating for preventing andtreating the foreign body reaction is difficult to delay and control drug release in a drug release process. Aiming at the problems in the prior art, the invention discloses a preparation method of amultiple drug fiber membrane for reducing a foreign body reaction of an implant material. The preparation method comprises the following steps of: firstly, preparing a nano fiber membrane with a 'skin-core' layer structure through a coaxial electrostatic spinning technology; and then spraying polymer microspheres containing an anti-fibrosis drug on the surface of the fiber membrane through a high-voltage electrostatic spraying technology. The preparation method provided by the invention is simple; and the prepared multiple drug fiber membrane has a multiple drug release system, and can realize multiple controlled release of drugs and reduce the foreign body reaction of the implant material.

Description

Technical field [0001] The invention relates to a preparation method of a multi-drug fiber membrane for reducing the foreign body reaction of implant materials, and belongs to the field of biological materials. Background technique [0002] Medical implant materials will cause foreign body reactions when entering the human body. So far, no completely "inert" materials that do not cause foreign body reactions have been put into use. The foreign body reaction caused by the implant material mainly includes the local inflammatory reaction on the surface of the implant material, the fusion of macrophages to form foreign body giant cells, and the formation of a fibrous envelope around the implant material. Drug coatings that will prevent the above three foreign body reactions To the surface of the implant material can reduce the foreign body reaction of the implant material. However, it is difficult for traditional drug coatings to delay and control the drug release during the drug re...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/16A61L31/06A61L31/04D04H1/728D01D5/00D01D5/34
CPCA61L31/042A61L31/045A61L31/06A61L31/16A61L2300/216A61L2300/406A61L2300/602D01D5/003D01D5/0069D01D5/0076D01D5/0084D01D5/0092D01D5/34D04H1/728C08L71/02C08L67/04C08L5/08
Inventor 赵亮亮许杉杉孟庆怡
Owner WUXI ZHONGKE GUANGYUAN BIOMATERIALS
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