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60results about How to "Rapid swelling" patented technology

Porous biological material using modified gelatin as crosslinking agent and preparation method of porous biological material

The invention provides a porous biological material using modified gelatin as a crosslinking agent and a preparation method of the porous biological material. The preparation method specially comprises the following steps: dissolving an acrylamide monomer, methacrylamide modified gelatin and inorganic nano-clay in deionized water, and stirring for 10 to 30 minutes in an inert atmosphere; adding a catalyst, stirring for 5 to 10 minutes in the inert atmosphere, and then adding an initiator; performing radical polymerization for 12 to 48 hours at the temperature of -30 DEG C to 30 DEG C; soaking the reaction product in the deionized water at 20 DEG C for 48 to 72 hours, and replacing the deionized water every 5 to 8 hours, and finally performing freeze-drying on the reaction product for 24 to 48 hours to obtain the porous biological material using modified gelatin as the crosslinking agent. The preparation method is simple in preparation process, the condition can be controlled, and the prepared porous biological material has the characteristics of good biocompatibility, mechanical property, macroporous property, quick swelling property and the like at the same time, and can be widely applied in the fields of biological scaffolds, cell culture, drug controlled release, tissue engineering, trauma and burn treatment and other biomedical materials.
Owner:SICHUAN UNIV

Medical multi-layer composite anti-adhesion membrane and preparation method thereof

The invention belongs to the technical field of biomedicine and particularly relates to a medical multi-layer composite anti-adhesion membrane and a preparation method thereof. The multi-layer composite anti-adhesion membrane comprises a gel membrane, a single surface or double surfaces of the gel membrane is a water-soluble membrane or are water-soluble membranes. During preparation, the gel membrane can be prepared firstly, and then the water-soluble membrane or the water-soluble membranes is/are arranged on the single surface or the double surfaces of the gel membrane in a curtain coating manner; besides, the gel membrane and the water-soluble membrane or the water-soluble membranes can be prepared respectively firstly and then composited in a little-water environment. With the adoption of the multi-layer composite anti-adhesion membrane, on one hand, the anti-adhesion membrane can be bonded to tissue and organs through slow dissolution of the water-soluble membrane or the water-soluble membranes, and suture fixing operation of the anti-adhesion membrane during an operation is avoided; on the other hand, due to stable existence of the gel membrane, the anti-adhesion membrane can still have effects of a mechanical support and a physical barrier after being implanted in a body for a longer time, and postoperative adhesion is inhibited. The multi-layer composite anti-adhesion membrane has the wide application value in postoperative adhesion prevention for parts such as hearts, abdominal cavities, pelvic cavities and the like.
Owner:TSINGHUA UNIV

Method for preparing macroporous quick-response polyacrylamide hydrogel by adopting frontal polymerization of acrylamide deep-eutectic solvent

The invention discloses a method for preparing macroporous quick-response polyacrylamide hydrogel by adopting frontal polymerization of an acrylamide deep-eutectic solvent, and belongs to the technical field of preparation of functional polymer materials. The method comprises the following steps: mixing acrylamide with a halogen-containing ammonium salt or halogen-containing quaternary ammonium salt or halogen-containing phosphonium salt compound, stirring at 80-100 DEG C until a transparent and clear liquid is formed, and cooling to obtain an acrylamide-based deep-eutectic solvent; adding a cross-linking agent and an initiator into the deep-eutectic solvent at the temperature of not lower than 35 DEG C to form a mixture solution; transferring the formed mixture solution into a tubular reactor, heating at the upper end or the lower end of the reactor by adopting a heat source to initiate a reaction, and removing the heat source until all the raw materials in the whole reactor are converted into polymer gel after the thermal initiation reaction is started; and soaking and washing the obtained polymer gel with distilled water, and freeze-drying to obtain the target hydrogel. No extraliquid solvent is needed, the polymerization speed is high, the reaction time is short, and the energy consumption is low.
Owner:HUBEI POLYTECHNIC UNIV

Preparation method for anti-adhesion film

The invention discloses a preparation method for an anti-adhesion film and belongs to the technical field of biomedicines. According to the invention, a degumming bamboo fiber is taken as a skeleton of the anti-adhesion film; during the preparation process of the degumming bamboo fiber, water and sodium ions start to permeate into the fiber; under a heating high-pressure condition, the tensile property of viscose can be longitudinally promoted and the toughness of the anti-adhesion film can be enhanced; the skeleton fiber of the anti-adhesion film provided by the invention has a superfine porestructure, is coated with a hydrophilic casting film fluid and is capable of achieving a strong adhesive effect between the anti-adhesion film and tissues as well as organs; the casting film fluid inthe invention contains the polymers, such as sodium carboxymethylcellulose, chitosan, hyaluronic acid and polylactic acid; sodium carboxymethylcellulose has characteristics of certain capabilities ofweakening fibroblast proliferation and inhibiting inflammatory reaction; collagen in mixed gel has a function of boosting recovery of fracture wound; various macromolecular substances in the anti-adhesion film are capable of degrading into easily absorbed micromolecular substances in human body; the anti-adhesion film has a bright application prospect.
Owner:赵玲萍
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