60results about How to "Rapid swelling" patented technology

A super-porous aqueo-gel of an interpenetrating network polymer used for the orally applying system of protein polypeptide to suppress proteinase and break the close linking between epithelial cells contains two polymers: a cross-linked polymer and a cross-linked polyose polymer. Its preparing process includes such steps as mixing at least one unsaturated enylmonomer, at least one polyenyl cross-linking agent, a linear polyose polymer and a foaming agent to generate the super-porous aqueo-gel of semi-interpenetrating network polymer, and cross-linking with linear polyose.

The invention discloses an ultra-multiaperture hydrogel compound, making method and application in pharmacy. It contains cross-linked polymer and Carbomer. At least one unsaturated alkene monomer and polyene cross-linking agent polymerize to develop it. The making steps: mix at least one unsaturated alkene monomer, one polyene cross-linking agent, Carbomer and one foaming agent; the mixture develops it on the condition of polymerizing and foaming. It can be used in stomach floating preparation and protein polypeptide oral medicine supplying system.

A zero-valent iron and biochar composite chemical for in-situ remediation of groundwater contaminated with chlorinated hydrocarbons is prepared from materials in percentage by weight as follows: 5%-30% of zero-valent iron powder, 8%-30% of a biochar source, 35%-85% of water, 0.1%-1% of a stabilizer, 1.5%-3% of a thickener, 0.3%-1% of an emulsifier and 0.01%-0.1% of a micronutrient source. The required raw materials are uniformly mixed by mixing equipment with high shearing for 15-30 min, and composite slurry which has good fluidity, is conducive to in-situ injection and can be stably stored is obtained. The prepared zero-valent iron and biochar source composite chemical has excellent fluidity and migration and diffusion capabilities and has a good remediation effect on complex contaminated sites containing both unsaturated and saturated chlorinated hydrocarbons. Besides, the selected raw materials are economic and available, the cost of the chemical is greatly reduced, and large-scale remediation of actual sites is facilitated.

The invention provides a porous biological material using modified gelatin as a crosslinking agent and a preparation method of the porous biological material. The preparation method specially comprises the following steps: dissolving an acrylamide monomer, methacrylamide modified gelatin and inorganic nano-clay in deionized water, and stirring for 10 to 30 minutes in an inert atmosphere; adding a catalyst, stirring for 5 to 10 minutes in the inert atmosphere, and then adding an initiator; performing radical polymerization for 12 to 48 hours at the temperature of -30 DEG C to 30 DEG C; soaking the reaction product in the deionized water at 20 DEG C for 48 to 72 hours, and replacing the deionized water every 5 to 8 hours, and finally performing freeze-drying on the reaction product for 24 to 48 hours to obtain the porous biological material using modified gelatin as the crosslinking agent. The preparation method is simple in preparation process, the condition can be controlled, and the prepared porous biological material has the characteristics of good biocompatibility, mechanical property, macroporous property, quick swelling property and the like at the same time, and can be widely applied in the fields of biological scaffolds, cell culture, drug controlled release, tissue engineering, trauma and burn treatment and other biomedical materials.

The invention discloses a biodegradable hydrogel and method for preparing same which consists of, preparing microporous konjak gluglucosan aqueous gel, preparing refined konjaku flour, dissolving in distilled water, agitating, charging inorganic solvent, adjusting pH, carrying out crossbridging under a controlled temperature and time, water scrubbing the product yield, repeated frost thawing, freeze-drying, then swelling the konjak gluglucosan gel into the aqueous solution of acroleic acid, cross linking agent, and initiating agent, carrying out polymerization under a controlled temperature and time, and water scrubbing the obtained outcome yield.

The invention relates to an active oxygen elimination antibacterial and anti-inflammatory hydrogel skin dressing and a preparation method thereof. The skin dressing is prepared by the ring-opening reaction of amino of acetone [bis-(2-amino-ethyl)-dithioalcohol] and 3,3'-dithiobis(propionohydrazide) with epoxy groups of poly (polyethylene glycol methyl ether methacrylate-co-glycidyl methacrylate) to form a main body hydrogel network, and meanwhile, polyvinyl alcohol chain segments are inserted into the hydrogel network to form a semi-interpenetrating network; the freeze-dried hydrogel is swelled in a hyperbranched polylysine solution to realize loading of antibacterial substances, so that the active oxygen eliminating antibacterial and anti-inflammatory hydrogel skin dressing can be obtained. The antibacterial and anti-inflammatory hydrogel skin dressing capable of eliminating active oxygen can be used for repairing skin injury, has broad-spectrum antibacterial and bacteriostatic effects, can achieve the effects of regulating and controlling the inflammation level of a wound part, promoting wound healing and reducing scar generation by eliminating excessive active oxygen at the wound part, and does not generate drug resistance.

The invention discloses rapidly hydrated liquid guanidine gum. The rapidly hydrous liquid guanidine gum consists of the following components by weight percentage: 16-49.6% of disperse phase, 50-83.3% of dispersion media and 0.4-10% of suspension stabilizers. The invention also discloses a fracturing base fluid. The fracturing base fluid is prepared by mixing the rapidly hydrated liquid guanidine gum with water at a weight ratio of 1: (50-500). The rapidly hydrated liquid guanidine gum can be rapidly swollen to be sticky and has excellent suspension stability. The preparation method is simple and easily available in raw materials, thereby facilitating large-scale production.

The invention discloses a polymer emulsifying and thickening agent and a preparation method thereof. The polymer emulsifying and thickening agent contains a plurality of polymerization monomers, wherein each polymerization monomer contains the following components in percentage by mass: 30.0-99.9% of anionic monomers and 0.1-10.0% of amphoteric cationic monomers; the anionic monomers are one or at least two selected from acrylic acid, methacrylic acid and 2-acrylamide-2-methylacrylsulfonate; the amphoteric cationic monomers are one or at least two selected from N, N-dimethyl-N-dodecyl methylallyl ammonium chloride, N, N-dimethyl-N-tetradecyl methylallyl ammonium chloride, N, N-dimethyl-N-dodecyl allyl ammonium chloride and N, N-dimethyl-N-dodecyl tetradecyl allyl ammonium chloride; and the weight-average molecular weight of the polymer emulsifying and thickening agent is 2000-6000 thousands. The polymer emulsifying and thickening agent is good in thickening and emulsifying effects and salt resistance, high in swelling speed and low in preparation cost and can be produced on a large scale.

The invention belongs to the field of biomedicine and particularly relates to soluble human keratin and application thereof. The soluble keratin is obtained through the following process of cloning amiddle sequence of a human gene K37, constructing a recombinant vector, transforming bacteria, inducing expression of the recombinant protein and purifying the recombinant protein to obtain the soluble keratin. The soluble keratin has the characteristic of rapid swelling and can promote mitosis and migration of epidermal cells, and therefore the soluble keratin can be used for preparing biologicalmaterials or medicaments for promoting cell proliferation or migration, and plays a role in hemostasis and wound healing. Moreover, the soluble keratin causes no rejection phenomenon when being usedfor the human body, is safe to use and thus has a wide application prospect in the field of biomedicine.

The invention relates to a preparation method of an intelligent gel material and in particular relates to a preparation method of thermosensitive ion imprinting gel. The method comprises the following steps: using chloromethyl styrene and amine compounds such as ethylenediamine to react to generate a ligand, then using the ligand and a specific metal perchlorate to react to obtain a complex which can chelate specific metal ions, using the complex, N-isopropylacrylamide, N,N'-methylenebisacrylamide, polyoxyethylene 10 stearate and azodiisobutyronitrile to perform a copolymerization reaction under a certain condition, and performing purification, separation and other processes to finally obtain the thermosensitive ion imprinting gel product which can chelate the specific metal ions. The thermosensitive ion imprinting gel material prepared by the method has the characteristics of thermosensitivity, ion recognition and strong identification response capability to metal ions, namely Cu<2+>, Ni<2+>, Co<2+>, Pt<2+>, Pd<2+>, Zn<2+>, Cd<2+> and Au<3+>.

The invention provides a method for hydrolyzing seaweed. The method is as follows: fresh or water expanded seaweed is shattered; ethylenediamine tetracetic acid, potassium hydroxide or sodium hydroxide, ferrous sulfate, hydrogen peroxide and vitamin C are sequentially added while the seaweed is stirred; and after filtration, the filtrate is added with boric acid or borate, and finally seaweed hydrolysate can be obtained. The invention has simple preparation method and required equipment, seaweed polysaccharides can be fast degraded into micromolecules, and the activity of natural active substances of the seaweed can be maintained.

The invention discloses fast-dissolving cationic polyacrylamide and a preparation method thereof. The method comprises the following steps: mixing a polyacrylamide solution, a cationic monomer solution, a weakly polar monomer, deionized water, disodium ethylenediamine tetraacetate, polyethylene oxide and urea to prepare a solution A; adding a photoinitiator into a chain transfer agent, performinguniform dissolution under stirring to prepare a solution B; uniformly mixing the solution A and the solution B under stirring to obtain a reaction solution; and adjusting the pH of the reaction solution to 3-6, introducing nitrogen for deoxygenation, performing irradiation under a short-wave ultraviolet lamp, performing irradiation under a long-wave ultraviolet lamp, cutting the prepared rubber block, performing granulation, performing drying, and performing crushing to obtain the fast-dissolving cationic polyacrylamide. The method provided by the invention greatly shortens the dissolution time of the cationic polyacrylamide, improves the use efficiency of the cationic polyacrylamide in industries such as water treatment, sludge dewatering, mineral dressing by washing, oil and gas extraction and papermaking, and has huge potential application value.

The invention belongs to the technical field of biomedicine and particularly relates to a medical multi-layer composite anti-adhesion membrane and a preparation method thereof. The multi-layer composite anti-adhesion membrane comprises a gel membrane, a single surface or double surfaces of the gel membrane is a water-soluble membrane or are water-soluble membranes. During preparation, the gel membrane can be prepared firstly, and then the water-soluble membrane or the water-soluble membranes is / are arranged on the single surface or the double surfaces of the gel membrane in a curtain coating manner; besides, the gel membrane and the water-soluble membrane or the water-soluble membranes can be prepared respectively firstly and then composited in a little-water environment. With the adoption of the multi-layer composite anti-adhesion membrane, on one hand, the anti-adhesion membrane can be bonded to tissue and organs through slow dissolution of the water-soluble membrane or the water-soluble membranes, and suture fixing operation of the anti-adhesion membrane during an operation is avoided; on the other hand, due to stable existence of the gel membrane, the anti-adhesion membrane can still have effects of a mechanical support and a physical barrier after being implanted in a body for a longer time, and postoperative adhesion is inhibited. The multi-layer composite anti-adhesion membrane has the wide application value in postoperative adhesion prevention for parts such as hearts, abdominal cavities, pelvic cavities and the like.

The invention discloses a method for preparing macroporous quick-response polyacrylamide hydrogel by adopting frontal polymerization of an acrylamide deep-eutectic solvent, and belongs to the technical field of preparation of functional polymer materials. The method comprises the following steps: mixing acrylamide with a halogen-containing ammonium salt or halogen-containing quaternary ammonium salt or halogen-containing phosphonium salt compound, stirring at 80-100 DEG C until a transparent and clear liquid is formed, and cooling to obtain an acrylamide-based deep-eutectic solvent; adding a cross-linking agent and an initiator into the deep-eutectic solvent at the temperature of not lower than 35 DEG C to form a mixture solution; transferring the formed mixture solution into a tubular reactor, heating at the upper end or the lower end of the reactor by adopting a heat source to initiate a reaction, and removing the heat source until all the raw materials in the whole reactor are converted into polymer gel after the thermal initiation reaction is started; and soaking and washing the obtained polymer gel with distilled water, and freeze-drying to obtain the target hydrogel. No extraliquid solvent is needed, the polymerization speed is high, the reaction time is short, and the energy consumption is low.

The invention discloses polymeric micelle having hydrophilic and hydrophobic terminals and having pH response, which comprises a structure shown as a formula (1). The invention also discloses a preparation method of the polymeric micelle and an application of the polymeric micelle as a water-insoluble medicine system. The polymeric micelle has good biocompatibility, and comprises pH-responded polyacrylic acid as a a hydrophilic terminal, and takes hydrophobic group and a pH-responded group random copolymer as a hydrophobic terminal, a core and a shell layer of the micelle have pH response groups, so that the micelle can rapidly and thoroughly respond the pH change of response environment, and phenomenon of burst release of the medicine in stomach and incomplete release of the medicine in small intestine can be effectively eliminated.

The invention discloses a special medical food thickening component for inhibiting esophageal regurgitation. The special medical food thickening component for inhibiting esophageal regurgitation is composed of the following ingredients (by mass): 2-6% of guar gum, 2-5% of locust bean gum, 2-6% of xanthan gum, 1-2% of carrageenan, 15-20% of gelatin, 8-12% of Arabic gum, 0.5-1% of polydextrose, 1-2%of sodium bicarbonate or potassium bicarbonate and 47-68% of glycerin. The invention also discloses a preparation method of the above special medical food thickening component. The special medical food thickening component for inhibiting esophageal regurgitation can form a cortex-wrapped gel-layer structure to facilitate swallowing; bicarbonate and gastric juice cause a swelling effect to accelerate cortex dissolution for pore-forming; rapid swelling helps thickening; and a gelatin-Arabic gum and guar gum-xanthan gum high-viscosity compound interspersed structure helps thickening efficiently.

The invention belongs to the field of biological materials. A medical implant material can generate a foreign body reaction when entering a human body, and a present, a drug coating for preventing andtreating the foreign body reaction is difficult to delay and control drug release in a drug release process. Aiming at the problems in the prior art, the invention discloses a preparation method of amultiple drug fiber membrane for reducing a foreign body reaction of an implant material. The preparation method comprises the following steps of: firstly, preparing a nano fiber membrane with a 'skin-core' layer structure through a coaxial electrostatic spinning technology; and then spraying polymer microspheres containing an anti-fibrosis drug on the surface of the fiber membrane through a high-voltage electrostatic spraying technology. The preparation method provided by the invention is simple; and the prepared multiple drug fiber membrane has a multiple drug release system, and can realize multiple controlled release of drugs and reduce the foreign body reaction of the implant material.

A water swelling water stop material comprised of a water permeable sheet, characterized in that water absorbent resin particles (A) are enclosed therein so that the water stop material upon water absorption and swelling has the configuration of polyhedron (B). The water stop material is thin to thereby facilitate storage thereof and is lightweight to thereby render carry thereof easy. The polyhedron (B) is so constructed that upon water absorption and swelling, at least two faces are planar. When the polyhedron (B) is formed into a rectangular solid or cube, even if multiple polyhedrons (B) are piled one upon another, they are stable and are resistant to collapse even under the influence of a large amount of water. When polyhedrons (B) of the same configuration are piled one upon another, any gaps between water stop materials are slight so as to inhibit water leakage through the gaps. Moreover, when the polyhedron (B) has a cavity, the cavity can be packed with a heavy solid material or can have a stake hammered therein so that the water stop material can stably resist violent water streams. Therefore, this water swelling water stop material can be appropriately used as a water stop material for rainwater penetration prevention in order to protect banks, buildings, houses, etc. in the event of flood, heavy rain, etc.

The invention discloses a range hood cleaning agent and a preparation method thereof. The range hood cleaning agent is prepared from, by weight, 10-15 parts of sodium alcohol ether sulphate, 10-15 parts of alkylphenol ethoxylate, 20-25 parts of coconutt diethanol amide, 1-10 parts of octadecanol, 5-30 parts of ethylene glycol monobutyl ether, 1-10 parts of ethanol, 1-10 parts of a penetrating agent BX, 1-10 parts of sodium alpha-olefin sulfonate, 1-3 parts of D-limonene, 1-5 parts of triethanolamine, 1-5 parts of ethylenediamine tetraacetic acid disodium and 200-250 parts of deionized water. Compared with existing range hood cleaning agents, the range hood cleaning agent can rapidly swell and emulsify oil dirt and quickly remove dust, oil dirt, stains, iron rust and the like attached to kitchen appliances such as a range hood through the synergistic function of all the components, the appliances are not damaged, the corrosion is small, and the cleaning effect is good; moreover, after use, there is no chemical residues on the range hood, and the cleaning agent is non-toxic and harmless to the human body.

The invention discloses a modified ABS material and a preparation method thereof. The material is prepared from the following raw materials in percentage by mass: 50-70% of ABS resin, 8-21% of ASA resin, 5-13% of ultrahigh-molecular-weight polyethylene, 6-15% of styrene, 1-5% of polyphenyl ether, 3-7% of a styrene grafted maleic anhydride copolymer and 0.8-2.5% of ethylene bis stearamide. The ABSmodified material prepared by the method has the advantages of high impact resistance, favorable aging resistance, favorable adhesiveness with paint, wear resistance, corrosion resistance and the like, endows ABS with higher economic value, and satisfies the high requirements for manufacturing high-performance materials.

The invention relates to an externally applied medicine for treating closed soft tissue injury and belongs to a Chinese medicine for external use. The externally applied medicine comprises 500 to 566 parts of root of red-rooted salvia, 500 to 566 parts of Chinese angelica, 500 to 566 parts of pangolin, 380 to 420 parts of peach kernel, 500 to 566 parts of safflower, 500 to 566 parts of frankincense, 500 to 566 parts of myrrh, 380 to 420 parts of gardenia, 380 to 420 parts of rhubarb and 380 to 420 parts of silk tree albizzia bark. The invention has the advantages that: the externally applied medicine is quick in transdermal absorption, can quickly eliminate mucosal swelling, has a remarkable analgesic effect and an exact therapeutic effect, does not have toxic or side effect and the like.

The invention discloses a superporous hydrogel composite, its preparation method and its application in pharmacy. The superporous hydrogel composite of the present invention contains a crosslinked polymer and carbomer, and has a superporous structure. The polymer is formed by polymerization of at least one unsaturated ethylenic monomer and a polyene crosslinking agent. The superporous hydrogel composite of the present invention is prepared by the following steps: mixing at least one unsaturated ethylenic monomer, a polyene crosslinking agent, carbomer and a foaming agent; Formation of superporous hydrogel composites under the condition of bubbles. The superporous hydrogel complex of the present invention can be used in gastric floating preparations and protein polypeptide oral drug delivery systems. Compared with the prior art, it has bioadhesive properties and protease inhibition.

The invention provides a guanidine gum fracturing fluid system prepared by using heavy oil thermal recovery water and a preparation method of the fracturing fluid system. The guanidine gum fracturingfluid system comprises liquid guanidine gum, an ion chelating agent, a crosslinking retarder, a gel breaker, a cross-linking agent and the balance of heavy oil thermal recovery water, wherein the temperature of the heavy oil thermal recovery water is 70-85 DEG C. Under the action of the heavy oil thermal recovery water and the ion chelating agent, the liquid guanidine gum can be uniformly dispersed and rapidly swelled in heavy oil hot water and reach 90% of sufficient swelling in a short time, and a fracturing base fluid can be crosslinked at a suitable speed under the action of the crosslinking agent and the crosslinking retarder. Compared with a current fracturing fluid, the fracturing fluid provided by the application has temperature-resistant ability of 95 DEG C, the viscosity of the fracturing fluid is always greater than 140 mPa*s when constant-temperature shear is performed at 60 DEG C and 170 S<-1> for 60 min, and therefore the fracturing performance of the fracturing fluid isgreatly improved.

The invention discloses a preparation method and application of linear poly(2-hydroxyethyl methacrylate) with different viscosity, and belongs to the technical field of synthesis of organic high molecular compounds and high molecular hydrogel. 2-hydroxyethyl methacrylate is adopted as a monomer, azobisisobutyronitrile is adopted as an initiator, dimethyl sulfoxide (DMSO) is adopted as a solvent, and the linear PHEMA with different viscosity is prepared under different reaction conditions. (2) N-isopropyl acrylamide is adopted as a monomer, PHEMA of 692 cp is adopted as a second network, polyethylene glycol 1500 is adopted as a porogenic agent, and poly(N-isopropyl acrylamide)-poly(2-hydroxyethyl methacrylate) porous semi-interpenetrating composite hydrogel is prepared by adopting a solution polymerization method. The hydogel has the advantages of obvious temperature sensitivity, a through hole structure and rapid swelling and deswelling abilities, the content of the linear PHEMA in thehydrogel network has a wide adjustable range, and the hydrogel is expected to become a carrier material with excellent performance.

The invention discloses a biodegradable hydrogel and method for preparing same which consists of, preparing microporous konjak gluglucosan aqueous gel, preparing refined konjaku flour, dissolving in distilled water, agitating, charging inorganic solvent, adjusting pH, carrying out crossbridging under a controlled temperature and time, water scrubbing the product yield, repeated frost thawing, freeze-drying, then swelling the konjak gluglucosan gel into the aqueous solution of acroleic acid, cross linking agent, and initiating agent, carrying out polymerization under a controlled temperature and time, and water scrubbing the obtained outcome yield.

The invention discloses a traditional Chinese medicine type medicinal bath solution for mink farming and a preparation method thereof. The traditional Chinese medicine type medicinal bath solution is prepared through the following raw materials: houttuynia cordata, adiantum edentulum Christ, cortex phellodendri, moutan bark, bark of Chinese catalpa, camellia olelfera abel residue, spinach beet, dandelion, fructus cnidii, patience dock root, radix ampelopsis, rhizoma paridis, ploygonatum cirrhifolium root, symplocos paniculata, chloranthus serratus, radices lithospermi, caulis trachelospermi, dalbergia odorifera, pulvis fumi carbonisatus, elephant hide, liquorice, vinegar, simmondsia chinensis seed oil, olive oil and triglycerol stearate emulsion. According to the traditional Chinese medicine type medicinal bath solution, the raw materials are pure natural Chinese herbal medicines and exclude any chemicals or antibiotics; a mink can be protected from suffering from various skin diseases; the traditional Chinese medicine type medicinal bath solution is convenient to use, and good in effect.

The invention discloses a neutral cleaning agent for a range hood and a preparation method thereof, and relates to the technical field of cleaning agent preparation. The neutral cleaning agent for therange hood comprises the following components in percentage by weight: 2-8% of a nonionic penetrating agent, 1-5% of polyethoxylated fatty alcohol, 1-5% of a nonionic surfactant, 2-5% of a solvent, 0.2-0.5% of sodium chloride, 0.01-0.02% of a defoaming agent, 0.1-0.3% of essence, 0.01-0.03% of a preservative, 0.01-0.03% of sodium hydroxide and the balance of softened water, wherein the nonionic penetrating agent comprises a KOC type efficient low-foam nonionic penetrating agent, the polyethoxylated fatty alcohol comprises AEO5-80, and the nonionic surfactant comprises an HSN38 type strippingagent. The neutral cleaning agent for the range hood has the advantages of mildness, no stimulation, capability of protecting the range hood and two hands from being corroded during cleaning, short effect taking time, high decontamination rate and long peculiar smell removal time.

The invention discloses a preparation method for an anti-adhesion film and belongs to the technical field of biomedicines. According to the invention, a degumming bamboo fiber is taken as a skeleton of the anti-adhesion film; during the preparation process of the degumming bamboo fiber, water and sodium ions start to permeate into the fiber; under a heating high-pressure condition, the tensile property of viscose can be longitudinally promoted and the toughness of the anti-adhesion film can be enhanced; the skeleton fiber of the anti-adhesion film provided by the invention has a superfine porestructure, is coated with a hydrophilic casting film fluid and is capable of achieving a strong adhesive effect between the anti-adhesion film and tissues as well as organs; the casting film fluid inthe invention contains the polymers, such as sodium carboxymethylcellulose, chitosan, hyaluronic acid and polylactic acid; sodium carboxymethylcellulose has characteristics of certain capabilities ofweakening fibroblast proliferation and inhibiting inflammatory reaction; collagen in mixed gel has a function of boosting recovery of fracture wound; various macromolecular substances in the anti-adhesion film are capable of degrading into easily absorbed micromolecular substances in human body; the anti-adhesion film has a bright application prospect.

The present invention relates to a rapidly swellable self-adhesive microneedle patch and a preparation method thereof, by modifying a hydrophilic polymer with a first modifying agent (one or a mixture of acrylic anhydride and methacrylic anhydride) , to synthesize an acrylated hydrophilic polymer; then, the catechol compound is reacted with the acrylated hydrophilic polymer for a second time to synthesize a catechol-modified acrylated hydrophilic polymer polymer, and the hydrophilic polymer has good biocompatibility, when the hydrophilic polymer is prepared into a microneedle patch, the microneedle patch has good biocompatibility, and at the same time, the microneedle patch The needle patch can quickly absorb liquid for swelling, and will not be blocked by skin tissue during the absorption process. Furthermore, due to the effect of catechol groups, it can adhere to the skin surface without additional adhesive plasters or tapes for fixing. Save time, effort and cost.