Biodegradable temperature-sensitive hydrogel and method for preparing same

Abstract

The invention discloses a biodegradable temperature-sensitive hydrogel and a preparation method thereof. First prepare macroporous konjac glucomannan hydrogel, weigh konjac fine powder, dissolve in distilled water, stir, then add inorganic alkali, adjust pH value, control a certain temperature and time for cross-linking, the product is washed with water, and freeze-thawed repeatedly Several times, freeze-dried; followed by swelling the macroporous konjac glucomannan hydrogel in a certain proportion of N-isopropylacrylamide, cross-linking agent, and initiator in an aqueous solution, controlling a certain temperature and time for polymerization, and obtaining The product was washed with water and then dried. The method of the invention is simple and effective, no organic solvent is used in the reaction, and the obtained hydrogel has good biodegradability and temperature sensitivity, and can absorb or embed drugs for controlled release of drugs. The invention has applications in biochemistry, medicine , agriculture, daily chemical industry and other fields have a variety of uses.

Description

technical field [0001] The invention relates to the field of biomedical polymer materials, more specifically to a biodegradable temperature-sensitive hydrogel, and also to a preparation method of the hydrogel, which is made of konjac glucomannan thermal alkali crosslinking, freeze-thawing treatment The resulting gel is an interpenetrating polymer network composed of poly-N-isopropylacrylamide. Background technique [0002] Polymer hydrogel is a body-shaped network of hydrophilic polymers that can swell in water and retain a large amount of water without dissolving. The many uses of hydrogels in the fields of biochemistry, medicine, agriculture, and daily chemical industry have aroused the general attention of scientists. Poly(N-isopropylacrylamide) hydrogel is a widely used synthetic polymer material with temperature sensitivity, but its non-biodegradability limits its application in biomedicine. [0003] As a natural polymer polysaccharide, k...

AI Technical Summary

Problems solved by technology

[0005] However, the preparation of konjac glucomannan and temperature-sensitive polymer interpenetrating network hydrogel has not been reported