Preparation method for anti-adhesion film

An anti-adhesion film and a technology for preparation steps, applied in the field of biomedicine, can solve the problems of general product degradation performance and poor tensile elasticity, and achieve the effects of maintaining mechanical properties and physical isolation properties, improving tensile properties, and enhancing toughness.

Inactive Publication Date: 2019-08-02
赵玲萍
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The main technical problem to be solved by the present invention is to provide a preparation method of an anti-adhesion film in view of the defects that the anti-adhesion film of polymer fiber is generally prepared by electrospinning method, the degradation performance of the product is general, and the tensile elasticity is poor.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0030] Preparation of silk fibroin solution: 70g bamboo fiber is placed in a beaker, and 100mL of sodium hydroxide solution, 8g sodium sulfite, and 10g sodium pyrophosphate are added to the beaker with a mass fraction of 45%. Heat up to 80°C at a heating rate of °C / min, keep warm for 1h, cool down to 40°C, continue to keep warm for 30min, remove the filtrate, wash with absolute ethanol, collect degummed bamboo fiber, and set aside;

[0031] Disperse 20g of dried silk fibroin in 200mL of 5% sodium hydroxide solution, heat up to 40°C, and keep it warm for 2h to obtain a dispersion. After cooling to room temperature, continue to drop 90mL of mass fraction into the dispersion. 2% acetic acid solution to obtain silk fibroin solution;

[0032] Preparation of mixed gel:

[0033] Take 100g of fish bone meal and disperse it into the beaker containing the above 200mL silk fibroin solution, heat the beaker in a water bath to 35°C, then add 40mL of acetic acid solution with a mass fracti...

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Abstract

The invention discloses a preparation method for an anti-adhesion film and belongs to the technical field of biomedicines. According to the invention, a degumming bamboo fiber is taken as a skeleton of the anti-adhesion film; during the preparation process of the degumming bamboo fiber, water and sodium ions start to permeate into the fiber; under a heating high-pressure condition, the tensile property of viscose can be longitudinally promoted and the toughness of the anti-adhesion film can be enhanced; the skeleton fiber of the anti-adhesion film provided by the invention has a superfine porestructure, is coated with a hydrophilic casting film fluid and is capable of achieving a strong adhesive effect between the anti-adhesion film and tissues as well as organs; the casting film fluid inthe invention contains the polymers, such as sodium carboxymethylcellulose, chitosan, hyaluronic acid and polylactic acid; sodium carboxymethylcellulose has characteristics of certain capabilities ofweakening fibroblast proliferation and inhibiting inflammatory reaction; collagen in mixed gel has a function of boosting recovery of fracture wound; various macromolecular substances in the anti-adhesion film are capable of degrading into easily absorbed micromolecular substances in human body; the anti-adhesion film has a bright application prospect.

Description

technical field [0001] The invention discloses a preparation method of an anti-adhesion film, belonging to the technical field of biomedicine. Background technique [0002] Adhesions are abnormal structures in which connective tissue fibers join together with adjacent tissues or organs, and can range in size from a fibrous film to a dense vascular scar. Postoperative adhesions are one of the common complications of surgery. According to reports, 50-100% of abdominal and pelvic surgery will lead to different degrees of adhesions. The sequelae caused by tissue adhesion after surgery are: continuous pain at the surgical site and loss of some functions. For example, adhesions caused after abdominal surgery may lead to intestinal obstruction, chronic pain, postoperative epilepsy and even infertility, which increases the difficulty of reoperation and the potential for complications. In surgical operations, how to prevent postoperative adhesions is still one of the important res...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/06A61L31/04A61L31/00A61L31/14
CPCA61L31/005A61L31/042A61L31/044A61L31/047A61L31/048A61L31/06A61L31/14A61L31/146A61L31/148C08L39/06C08L67/04C08L5/08C08L1/284C08L1/12C08L89/00
Inventor 赵玲萍
Owner 赵玲萍
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