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75results about How to "Increasing concentration gradient" patented technology

Method for supporting, regulating and controlling amplification of hematopoietic stem/progenitor cell in vitro with microencapsulation osteoblast in hypoxia condition

The invention discloses a method for encapsulated osteoblasts to support and regulate the in-vitro amplification of cord blood hematopoieticstem/progenitorcells (He) in the hypoxia condition, belonging to the fields of biotechnology and tissue TSPCS engineering. The method is characterized in that the human osteoblasts are embedded by gelatin-alginate-chitosan (GAC) microcapsule as matrix feeder cells and co-cultured with the cord blood HSPCs in the 5% hypoxia environment to obtain the HSPCs. The invention adopts GAC microcapsule to separate the human osteoblasts from the cord blood HSPCs to avoid the cell contamination and immunological rejection. Furthermore, the pore passages of the microcapsule are capable of causing hemopoietic growth factors secreted by the osteoblasts in the microcapsule to expand to the habitat of the HSPCs and play a role of stimulating the amplification of the hematopoietic stem/progenitor cells. Moreover, the material of the microcapsule has the slow release function to the expansion of the growth factors to increase the concentration gradient of the growth factors on the surface of the microcapsule, which is helpful for the long-term function of the growth factor. In addition, the microencapsulated osteoblasts form the 3D environment, which not only causes the culture system to contain more osteoblasts, but also causes the culture system to have bigger HSPCs-OBs action area compared with the co-culture pattern of the osteoblasts cultured by adherence. Besides, in the 5% hypoxia environment, the co-culture system is capable of better simulating the hematopoietic microenvironment iche of human bone marrow the osteoblasts have significant effects on the characteristic maintenance and number amplification of stem cells of the HSPCs.
Owner:DALIAN UNIV OF TECH

Reactor and method for preparing epoxypropane by reactor

The invention discloses a reactor. The middle of the reactor is filled with an epoxidation catalyst, the top wall of the reactor is provided with a gas outlet, the upper side wall of the reactor is provided with a liquid outlet, the lower side wall of the reactor is provided with one or two groups of injectors, each group of the injectors comprises two injectors symmetrically distributed on the same plane, the injector comprises a jet pipe and a nozzle connected to the jet pipe, the nozzle is frustoconical, the diameter of one end of the nozzle connected to the jet pipe is greater than that of the other end, the nozzle stretches into a fixed bed reactor, the jet pipe comprises two sections, the section of the jet pipe far away from the nozzle is cylindrical, the other section is frustoconical, and the diameter of one end of the jet pipe far away from the nozzle is greater than the diameter of one end of the jet pipe connected to the nozzle. The invention discloses a method for preparing epoxypropane by the reactor and a reaction system composed of the reactors connected in series. The reactor realizes reactant high-speed clashing mixing, improves reactant mixing effects, improves heat and mass transfer effects and improves a cumene hydroperoxide conversion rate and epoxypropane selectivity.
Owner:HONGBAOLI GRP CO LTD +1

Control system of carbon intensity distribution of low-pressure carburized layer and control method thereof

ActiveCN102063110AAvoid out-of-classOvercome the disadvantage of not being able to correctly carburize the carbon concentration distributionSolid state diffusion coatingTotal factory controlControl systemCarbide
The invention relates to a control system of the carbon intensity distribution of a low-pressure carburized layer and a control method thereof, belonging to the technical field of metal heat treatment. The control system comprises a low-pressure carburizing furnace, a controller, a pressure sensor, a thermoelectric couple, a nitrogen regulating valve, a nitrogen input pipe, a carburizing gas regulating valve, a carburizing gas input pipe, a vacuum system and a gas suction pipe. The invention simulates automatic optimized low-pressure pulse process parameters by using carburized layer concentration distribution values and realizes the control functions; the carburizing gas regulating valve executes on/off action according to an order of the controller to control carburizing section time and diffusing section time, therefore the accurate control of the intensity distribution of the carburized layer is realized; and in addition, the invention can keep high carburizing speed and prevent the tolerance of surface carbides, accurately controls the surface carbon intensity and the depth and the intensity distribution of the carburized layer, reduces the accumulated carbon black inside the low-pressure carburizing furnace, is free from depending on a gas component sensor and has the advantages of configuration simplification, easy implementation, high reliability and easy maintenance.
Owner:SHANGHAI JIAO TONG UNIV +1

All-solid-phase synthesis method for high-polymer materials with tumor site enzyme sensitive characteristics for constructing vesicae

The invention relates to the field of synthesis of high-polymer materials, in particular to an all-solid-phase synthesis method for high-polymer materials with tumor site enzyme sensitive characteristics for constructing vesicae. The all-solid-phase synthesis method has the advantages that the high-polymer materials are synthesized by the aid of the all-solid-phase synthesis method, the all-solid-phase synthesis method is easy to implement, short in synthesis period and high in product yields, and only few byproducts can be generated; the high-polymer materials can be subjected to self-assembly to form the vesicae, water-soluble medicines are encapsulated in internal water phases and can be degraded by high-expression MMP-9 enzymes at tumor sites after being targeted to tumor tissues, accordingly, the vesicae can be broken, and antitumor medicines can be instantly released; the tumor tissue targeting ability of the medicines can be improved by vesica medicine delivery systems constructed by the aid of the high-polymer materials, the medicines can be released in a responsive manner, the concentration of the medicines at the tumor sites can be increased, and the toxicity of the antitumor medicines on normal tissues and cells can be reduced.
Owner:CHINA PHARM UNIV

Flash memory and manufacturing method thereof

InactiveCN102738169ASuppression of punch-through effectImprove programming efficiencyTransistorSolid-state devicesGate stackEngineering
The invention discloses a flash memory and a manufacturing method thereof, belonging to the technology field of a semiconductor memory. The flash memory includes a buried oxide layer on which a source terminal, a channel and a drain terminal are arranged. The channel locates between the source terminal and the drain terminal. A tunnel oxide layer, a polysilicon floating gate, a barrier oxide layer and a polysilicon controlling gate are arranged on the channel in order. A thin silicon nitride layer is arranged between the source terminal and the channel. The manufacturing method comprises the following steps of: (1) providing an SOI silicon substrate with shallow trench isolation and forming an active area; (2) growing the tunnel oxide layer and a first polysilicon layer on the silicon substrate in order and preparing the polysilicon floating gate, and growing the barrier oxide layer and a second polysilicon layer and preparing the polysilicon controlling gate; (3) etching and forming a gate stacking structure; (4) preparing the drain terminal on one side of the gate stacking structure, etching a thin silicon film on the other side of the gate stacking structure, growing the thin silicon nitride layer, then backfilling a material of silicon, and preparing the source terminal. The flash memory and the method have the advantages of high programming efficiency, low power consumption, and capability of inhibiting a source-drain punch-through effect effectively.
Owner:PEKING UNIV

Method for preparing composite separator for lithium sulfur battery

The present invention relates to the technology of lithium sulfur batteries, and aims to provide a method for preparing a composite separator for a lithium sulfur battery. The method comprises the following steps: a polyamide acid solution is obtained by reaction of diamine and dianhydride, which is used as a spinning solution for spinning film formation; polyimide spinning base film is obtained after thermal imidization treatment; the polyamic acid solution is mixed with small nitrogen-containing molecules and graphene oxide and then subjected to spinning film formation, and after thermal imidization and carbonization treatment, self-supporting reduced graphene oxide/nitrogen-doped carbon nanofiber is obtained; the polyimide spinning base film and the reduced graphene oxide/nitrogen-dopedcarbon nanofiber are taken; and the two layers are laminated and sliced to obtain the composite separator for assembling the lithium sulfur battery. The separator of the invention has good heat resistance and flame resistance, can greatly improve the safety performance of the lithium sulfur battery, reduces the internal resistance of the battery and enhances the electrochemical performance of thebattery. High charge and discharge specific capacity, high cyclicity and safety of the lithium sulfur battery are realized.
Owner:QUZHOU RES INST OF ZHEJIANG UNIV

Miniature box-type leacher for special oil

InactiveCN104450171AImprove leaching production effectGuaranteed operabilityFatty-oils/fats productionEngineeringCirculating pump
The invention discloses a miniature box-type drag chain scraper flipover leacher. The miniature box-type drag chain scraper flipover leacher comprises a box-type leacher shell, wherein a plurality of driving chain wheels are arranged in the box-type leacher shell, and are sleeved by box chains; spaced push plates are fixedly arranged on the outer side of the box chains; material storage tanks, manholes and discharge holes are respectively formed in the upper end and the lower end of the box-type leacher; feeding augers are arranged below the material storage tanks; a plurality of push box lattices as leaching units are arranged in the box-type leacher; circulating mixed oil forms a soaking pond above each push box lattice; a plurality of oil buckets are formed in the bottom surface of the box-type leacher shell; and circulating pumps are arranged at oil inlets of the oil buckets. The miniature box-type drag chain scraper flipover leacher adopts a dual-layer multi-nozzle spray-type low material level, is suitable for a preform which is large in particle size and high in moisture content (5%-8%) and of which the normal moisture is not greater than 8%-10%; the equipment operation is controllable; the production operation is stable; blanking and meal discharging are stable; the residual meal discharge oil is not greater than 1.0%; the leaching time is controlled at about 90-120 minutes in general according to the oil variety; and the optimal effect of continuous production of the special oil is achieved.
Owner:DATUANJIE AGRI CO LTD

Selective etching method and preparation method of nano needle tip structure

The invention provides a selective etching method and a preparation method of a nano needle tip structure. The selective etching method comprises the following steps that a first material layer and asecond material layer are sequentially formed on a substrate, the isotropic etching selection ratio of the first material layer to the second material layer is larger than 10, the first material layercontains doping elements, and the concentration of the doping elements is linearly increased in the thickness direction of the first material layer; and selective isotropic etching is performed on the first material layer, wherein the etching rate of the selective isotropic etching has a positive linear relationship with the concentration of the doping elements, so as to complete the etching of the outer wall of the first material layer. According to the invention, the positive linear relationship between the etching rate in the etching process and the concentration of the doping elements inthe to-be-etched material is utilized, so that sloped sidewalls opposite to the increasing direction of the concentration is obtained; by the adoption of the selective etching method, the nano needletip structure with high sharpness can be obtained, and the size, the shape and the angle of the needle tip structure can be flexibly adjusted.
Owner:INST OF MICROELECTRONICS CHINESE ACAD OF SCI

Granular sludge sewage treatment device capable of controlling diameter and density of granules

The invention discloses a granular sludge sewage treatment device capable of controlling diameter and density of granules. The device comprises an inner barrel and an outer barrel which are concentric; an aeration device is arranged in an annular space between the inner barrel and the outer barrel; the aeration device is fixed on a pedestal through a supporting pile of the aeration device; the inner barrel wall of the inner barrel is connected with a cylindrical cyclone cylinder; the lower end of the cyclone cylinder is connected with a wall through pipe, the wall through pipe passes through the walls of the inner barrel and the outer barrel, and the side wall of the cyclone cylinder is provided with an overflow hole; and a water inlet funnel is fixed at the upper barrel port of the inner barrel, the water inlet funnel is connected with a spiral thin bent pipe, and the outlet of the thin bent pipe is tightly attached to the inside wall of the cyclone cylinder. On the basis of ensuring good outlet water quality, the device successfully realizes human control and selection of the diameter and the density of the aerobic sludge granules, and realizes proper solid-liquid separation; in addition, through the device, the initial granule forming speed is high, and the sludge load is balanced; the oxygenation efficiency is improved by gas-liquid separation; and the device has the advantages of energy conservation and high efficiency.
Owner:XI'AN UNIVERSITY OF ARCHITECTURE AND TECHNOLOGY

Ultrasonic wave and dry air combined production line drying equipment

The invention relates to the technical field of food washing, in particular to ultrasonic wave and dry air combined production line drying equipment. The ultrasonic wave and dry air combined production line drying equipment comprises an elevator and a drying shell; the drying shell is fixedly connected to the right end of the elevator; an anti-dust device is fixedly connected to the internal sideof the top end of the drying shell; a buffering device is fixedly connected to the internal side of the drying shell; a controller is fixedly connected to the right end of the drying shell; a door plate is rotationally connected to the right end of the drying shell through a hinge; a collection box is arranged at the bottom end of the drying shell; and a chain wheel is rotationally connected to the internal side of the drying shell. According to the ultrasonic wave and dry air combined production line drying equipment, by arranging a stainless steel water pipe, an insulation pipe, a condensingdehumidifier, a centrifugal fan, an air energy heat pump and a heating heat exchanger, the labor is saved through continuous conveying, and the labor intensity is reduced; and ultrasonic wave and static electricity are combined with dry air with a heat pump as a heat source, the product is sterilized and uniformly water-evaporated under the double effect of the ultrasonic wave and the static electricity at a lower temperature, and therefore, the drying time is shortened and is 1/4 of the common drying time.
Owner:福建一创机械设备有限公司

Miniaturized extracting concentrating machine set and formulation production technique thereof

The invention discloses a miniaturized extracting and concentrating unit and its preparation production process. The concentrating tank, extracting tank and liquid receiving tank are sequentially arranged side by side on a support, and the concentrating tank (1) and the extracting tank (2) pass through a pipeline (8 ) is connected, and is connected with the condenser through another pipeline (9), and a liquid suction pump (21) and a pipeline filter (20) are connected in sequence between the pipeline (8) and the bottom of the extraction tank, and its cooling A vacuum converter (7) is housed between the device (4) and the extraction tank, and a vacuum pump (16) is connected to the upper cavity of the vacuum converter. Its production process is: negative pressure extraction, negative pressure concentration, negative pressure reflux treatment and repeated circulation can be performed on Chinese herbal medicines until the active ingredients of the extract in the extraction tank are extracted, and then all the extract is sucked into the concentration tank to continue concentration. Until the concentrate in the concentration tank meets the requirements. The invention has the advantages of compact structure, small occupied space, energy-saving, high-efficiency, scientific and reasonable preparation process, and effectively improves the quality and extraction efficiency of the pharmaceutical preparation.
Owner:ZHEJIANG SUNNY MACHINERY TECH

Process for extracting bacterial cell coenzyme Q10

The invention relates to a technology for extracting coenzyme Q10 in bacterial cells, which pertains to the technical field of microbiology engineering. Thalli is automatically and quantitatively put into from the dog-house of a continuous countercurrent device under the control of a weigh-instrument, a solvent is injected from a solvent inlet under the control of a flowmeter and the leaching solution and the thalli form reverse continuous countercurrent leaching process under the push of a shovel-like thruster; the concentration gradient is large, relative movement exists between the solventand the thalli and the thalli moves from the left end to the right end of an extraction container continuously under the function of the shovel-like thruster while the solvent moves from the right end to the left end of the container under the action of pressure; a diffusion boundary layer is thin and fast to be updated and the coenzyme Q10 is extracted after 2 to 10 hours of reaction of the thalli which enters from the left end of the device after the contact of the solvent and the thalli; the thalli enters a rake type dryer from the right end of an extraction device by press treatment and residual organic solvent in the thalli is treated with drying treatment in the rake type dryer; the yield of the coenzyme Q10 reaches more than 90 percent.
Owner:SHENZHOUSPACEBIOTECHGRP +1
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