Coenzyme Q10 clear preparation being added into skin caring articles and preparation method thereof

Abstract

The present invention provides a coenzyme Q10 clear preparation which is added into skin caring articles and a preparation method thereof, and belongs to the technical field of personal caring article preparation. The coenzyme Q10 clear preparation comprises the following components: coenzyme Q10, emulsifier mixture, pH regulator, stabilizer and water. The particle size of microemulsion of the coenzyme Q10 is less than 150nm. The microemulsion solution is yellow clear water solution. Furthermore the coenzyme Q10 clear preparation has the following advantages: low viscosity, better fluidity, and high stability. The coenzyme Q10 clear microemulsion preparation prepared according to the invention overcomes the following defects in coenzyme Q10: low water solubility, low oil solubility, and high difficulty of being added into personal caring article. Simultaneously the preparation performs antioxidation and anti-aging biological activity on the skin. The process for preparing the personalnursing product which comprises the coenzyme Q10 is simplified. A novel dosage form is provided for the application of the coenzyme Q10 on the aspect of personal nursing product.

Description

technical field

[0001] The invention belongs to the technical field of preparation of personal care products, in particular to a coenzyme Q added to skin care products 10 Clarification of the formulation and its method of preparation. Background technique

[0002] coenzyme Q 10 It is a fat-soluble quinone compound with antioxidant effect, and is an important antioxidant and non-specific immune enhancer in the human body.

[0003] coenzyme Q 10 It has anti-oxidation and anti-aging effects on the skin. According to literature reports, coenzyme Q 10 It can enhance the anti-inflammatory effect of fibroblasts, promote the ability of fibroblasts to secrete mucopolysaccharides, reduce the loss of hyaluronic acid in the skin, promote the proliferation of epidermal cells, and play an anti-aging effect. Coenzyme Q in the skin 10 Levels decrease with age and UV exposure, therefore, adding CoQ to personal care products 10 It can reduce the skin photoaging effect and the damage of...

Examples

Embodiment 1

[0033] coenzyme Q 10 1g polyoxyethylene hydrogenated castor oil 2g

[0034] Polyethylene glycol caprylic acid / capric glyceride 1g Sodium carboxymethyl cellulose 0.3g

[0035] Deionized water 95.7g prepared with coenzyme Q 10 Clarified microemulsion 100g

[0036] Add the recipe amount Coenzyme Q 10 Stir slowly with polyoxyethylene hydrogenated castor oil and ethylene glycol caprylic acid / capric glyceride at 70 to form a uniform solution, add it to the aqueous solution containing carboxymethylcellulose sodium, and shear at 13000 rpm for 2 minutes ; put the material into the high-pressure homogenizer, and circulate 3 times at 150mpa to obtain coenzyme Q 10 Clarify the microemulsion solution, the pH value of the microemulsion solution is 6.6, and its particle size measured by laser particle size analyzer is 120nm.

[0037] The results of skin cytology experiments show that this dosage form can reduce the metalloproteinase and active oxygen content in cells that are increased ...

Embodiment 2

[0039] coenzyme Q 10 5g Cetearyl Glucoside 2g

[0040] Polyethylene Glycol Cetyl Ether 10g Sodium Carboxymethyl Cellulose 5g

[0041] Deionized water 74.5g prepared with coenzyme Q 10 Clarified microemulsion 100g

[0042] Add the recipe amount Coenzyme Q 10 Stir slowly with oleyl polyether phosphate and polyethylene glycol ceteth to form a homogeneous solution, add it to the aqueous solution containing carboxymethylcellulose sodium, and shear at 15,000 rpm for 2 minutes; put Feed into high-pressure homogenizer, circulate 6 times with 150mpa, obtain coenzyme Q 10Clarify the microemulsion solution, the pH value of the microemulsion solution is 6.7, and its particle size is 100nm as measured by a laser particle size analyzer.

Embodiment 3

[0044] coenzyme Q 10 10g oleyl ether phosphate 5g

[0045] Polyethylene glycol ceteth 10g Acrylate 1g

[0046] Deionized water 74g prepared with coenzyme Q 10 Clarified microemulsion 100g

[0047] Add the recipe amount Coenzyme Q 10 Stir slowly with oleyl polyether phosphate and oleyl polyether phosphate to form a uniform solution, add it to the aqueous solution containing carboxymethyl cellulose sodium, and shear at 18000 rpm for 3 minutes at high speed; put the material into the high pressure The homogenizer circulates twice at 200mpa, and adjusts the pH value to 6.4 with 5% sodium hydroxide solution. get coenzyme Q 10 The clarified microemulsion solution has a particle size of 105nm as measured by a laser particle size analyzer.

[0048] After the dosage form is placed at normal temperature (25° C.), it remains stable and transparent, and there is no stratification after 6 months. It can be placed stably for 3 months after accelerated test at 45°C.

technical field

[0001] The invention belongs to the technical field of preparation of personal care products, in particular to a coenzyme Q added to skin care products 10 Clarification of the formulation and its method of preparation. Background technique

[0002] coenzyme Q 10 It is a fat-soluble quinone compound with antioxidant effect, and is an important antioxidant and non-specific immune enhancer in the human body.

[0003] coenzyme Q 10 It has anti-oxidation and anti-aging effects on the skin. According to literature reports, coenzyme Q 10 It can enhance the anti-inflammatory effect of fibroblasts, promote the ability of fibroblasts to secrete mucopolysaccharides, reduce the loss of hyaluronic acid in the skin, promote the proliferation of epidermal cells, and play an anti-aging effect. Coenzyme Q in the skin 10 Levels decrease with age and UV exposure, therefore, adding CoQ to personal care products 10 It can reduce the skin photoaging effect and the damage of...

Examples

Embodiment 1

[0033] coenzyme Q 10 1g polyoxyethylene hydrogenated castor oil 2g

[0034] Polyethylene glycol caprylic acid / capric glyceride 1g Sodium carboxymethyl cellulose 0.3g

[0035] Deionized water 95.7g prepared with coenzyme Q 10 Clarified microemulsion 100g

[0036] Add the recipe amount Coenzyme Q 10 Stir slowly with polyoxyethylene hydrogenated castor oil and ethylene glycol caprylic acid / capric glyceride at 70 to form a uniform solution, add it to the aqueous solution containing carboxymethylcellulose sodium, and shear at 13000 rpm for 2 minutes ; put the material into the high-pressure homogenizer, and circulate 3 times at 150mpa to obtain coenzyme Q 10 Clarify the microemulsion solution, the pH value of the microemulsion solution is 6.6, and its particle size measured by laser particle size analyzer is 120nm.

[0037] The results of skin cytology experiments show that this dosage form can reduce the metalloproteinase and active oxygen content in cells that are increased ...

Embodiment 2

[0039] coenzyme Q 10 5g Cetearyl Glucoside 2g

[0040] Polyethylene Glycol Cetyl Ether 10g Sodium Carboxymethyl Cellulose 5g

[0041] Deionized water 74.5g prepared with coenzyme Q 10 Clarified microemulsion 100g

[0042] Add the recipe amount Coenzyme Q 10 Stir slowly with oleyl polyether phosphate and polyethylene glycol ceteth to form a homogeneous solution, add it to the aqueous solution containing carboxymethylcellulose sodium, and shear at 15,000 rpm for 2 minutes; put Feed into high-pressure homogenizer, circulate 6 times with 150mpa, obtain coenzyme Q 10Clarify the microemulsion solution, the pH value of the microemulsion solution is 6.7, and its particle size is 100nm as measured by a laser particle size analyzer.

Embodiment 3

[0044] coenzyme Q 10 10g oleyl ether phosphate 5g

[0045] Polyethylene glycol ceteth 10g Acrylate 1g

[0046] Deionized water 74g prepared with coenzyme Q 10 Clarified microemulsion 100g

[0047] Add the recipe amount Coenzyme Q 10 Stir slowly with oleyl polyether phosphate and oleyl polyether phosphate to form a uniform solution, add it to the aqueous solution containing carboxymethyl cellulose sodium, and shear at 18000 rpm for 3 minutes at high speed; put the material into the high pressure The homogenizer circulates twice at 200mpa, and adjusts the pH value to 6.4 with 5% sodium hydroxide solution. get coenzyme Q 10 The clarified microemulsion solution has a particle size of 105nm as measured by a laser particle size analyzer.

[0048] After the dosage form is placed at normal temperature (25° C.), it remains stable and transparent, and there is no stratification after 6 months. It can be placed stably for 3 months after accelerated test at 45°C.

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