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Centella total-glycoside diacolation-extracting method from centella

A technology for extracting centella glucosides and percolation, which is applied in the field of extracting centella glucosides, which can solve the problems of difficult process amplification, difficult industrial application, high equipment cost, etc., and achieves high extraction rate, reduced dosage, and reduced production cost effect

Inactive Publication Date: 2009-06-17
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The literature (Chinese Medicinal Materials, 2003, 26(3): 204) discloses a method for ultrasonically assisted extraction of asiaticosides, but the method has high equipment costs and difficult process amplification, so it is difficult for industrial application

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Crush the dried centella asiatica to obtain centella asiatica powder with a particle size of 5-60 meshes, weigh 60 grams of centella asiatica powder and put it into a percolation column (Φ3.0cm×70cm), compact it, and its bulk volume is about 370 milliliters, add 1 times of Centella asiatica bulk volume, 70% ethanol aqueous solution by volume percentage concentration, soak at 40 ℃ for 1 hour; Add, flow through the percolation column from top to bottom, the flow rate is 0.5 times the accumulation volume of Centella asiatica per hour, the temperature is 40 ° C, the leachate is collected, concentrated under reduced pressure to obtain the total glycosides extract of Centella asiatica; The deionized water of grass bulk volume is added from the top of the percolation column to replace the residual ethanol in Centella asiatica, the flow rate is 0.5 times of Centella asiatica bulk volume / hour, and the temperature is 40°C. Ethanol is recovered in other ways. The composition of t...

Embodiment 2

[0020] Crush the dried centella asiatica to obtain centella asiatica powder with a particle size of 5-60 meshes, weigh 60 grams of centella asiatica powder and put it into a percolation column (Φ3.0cm×70cm), compact it, and its bulk volume is about 370 milliliters, add 0.6 times of Centella asiatica bulk volume, 50% ethanol aqueous solution by volume percentage concentration, soak at 70 ℃ for 0.2 hour; Add, flow through the percolation column from top to bottom, the flow rate is 0.5 times the accumulation volume of Centella asiatica per hour, the temperature is 70 ° C, the leachate is collected, concentrated under reduced pressure to obtain the total glycosides extract of Centella asiatica; The deionized water with the bulk volume of grass is added from the top of the percolation column to replace the residual ethanol in Centella asiatica. Ethanol is recovered in other ways. The composition of the extract of asiaticosides was analyzed by reversed-phase high performance liquid...

Embodiment 3

[0022] Crush the dried centella asiatica to obtain centella asiatica powder with a particle size of 5-60 meshes, weigh 60 grams of centella asiatica powder and put it into a percolation column (Φ3.0cm×70cm), compact it, and its bulk volume is about 370 ml, add 1 times of centella asiatica bulk volume, 30% volume percentage concentration of ethanol aqueous solution, soak at 50 ℃ for 1 hour; Add, flow through the percolation column from top to bottom, the flow rate is 0.5 times the accumulation volume of Centella asiatica per hour, the temperature is 50 ° C, the leachate is collected, concentrated under reduced pressure to obtain the total glycosides extract of Centella asiatica; then 1.5 times the centella asiatica The deionized water with the bulk volume of grass is added from the top of the percolation column to replace the residual ethanol in Centella asiatica, the flow rate is 1 times the bulk volume of Centella asiatica per hour, and the temperature is 50°C. Ethanol is rec...

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Abstract

The invention discloses a method for extracting asiaticoside from asiatic centella comprising the step of using asiatic centella as raw material, and water solution of ethanol or methanol as extraction solvent for extracting asiaticoside from asiatic centella in high efficiency by percolation method for achieving more than 93% extraction ratio for the asiaticoside. The method has high extraction ratio, small consumption of solvent, low production cost, and easy commercial process.

Description

technical field [0001] The invention relates to a method for extracting centella asiaticosides, in particular to a method for extracting asiaticosides from centella asiatica by percolation. Background technique [0002] Centella asiatica is a traditional Chinese medicine in my country. According to ancient pharmacopoeia, Centella asiatica is mainly used to treat diseases such as damp-heat jaundice, heatstroke and diarrhea, sandy and bloody stranguria, carbuncle sores, and bruises. The main active ingredient of Centella asiatica is total asiaticoside, including pentacyclic triterpene saponins such as asiaticoside and madecassoside. Modern medical research shows that asiaticosides have significant physiological activities and can be used to treat depression, skin wounds, gastric ulcers, infectious hepatitis, skin diseases, and epidemic cerebrospinal meningitis. Therefore, the research on the extraction technology of asiaticosides has obvious application value. [0003] There...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/23A61P1/04A61P1/16A61P17/00A61P25/24A61P31/14A61P31/20
Inventor 邢华斌苏云苏宝根杨亦文任其龙姜丽燕
Owner ZHEJIANG UNIV
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