Interpenetrating network polymer type super porous aquogel, its prepn. method and application

The technology of porous hydrogel and interpenetrating network is applied in the field of interpenetrating network polymer superporous hydrogel and its preparation, which can solve the problems of unsuitable oral administration of protein and polypeptide drugs, brittleness and lack of elasticity. Achieve the effect of protecting protein and polypeptide substances, increasing mechanical strength and inhibiting protease

Inactive Publication Date: 2006-04-12
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Although the mechanical strength of the second-generation superporous hydrogel SPHC has been improved, when it is fully swollen, it is brittle because it is not elastic, and it is brittle under the action of various external forces.
The water-soluble polymers used in the above polymers are polyvinyl alcohol and polyethylenediamine. Due to the limitations of the properties and toxicity of polyvinyl alcohol and polyethylenediamine, they are not suitable as carriers for oral administration of protein and polypeptide drugs.

Method used

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  • Interpenetrating network polymer type super porous aquogel, its prepn. method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Example 1 Poly(acrylic acid-acrylamide) IPN-SPH containing chitosan

[0048] In a tall weighing bottle (40mm×25mm), add the following ingredients in sequence: 300μl 50% AM (acrylamide); 200μl 50% AA (acrylic acid); 100μl 2.5% BIS (N, N′-methylene) -Bisacrylamide); 300μl DDW (double distilled water); 30μl 10% Pluronic  F127 (PF127, Poloxamer); 25μl 20% APS (ammonium persulfate); 25μl 20% TEMED (N,N,N',N'-tetramethylethylenediamine); 300μl 4% shell Glycan (dissolved with 2% acetic acid). After adding each ingredient, shake the mixed solution. Add 120 mg of sodium bicarbonate 2 minutes before gelation occurs, vortex and shake. Place the above-mentioned superporous hydrogel polymer containing chitosan in 1% glutaraldehyde-containing HCl / absolute ethanol (3:7, v / v) for 2 hours to obtain poly( Acrylic acid-acrylamide) IPN-SPH.

Embodiment 2

[0049] Example 2 Poly(acrylic acid-acrylamide) IPN-SPH containing chitosan hydrochloride

[0050] In a tall weighing bottle (40mm×25mm), add the following ingredients in sequence: 300μl 50% AM (acrylamide); 200μl 50% AA (acrylic acid); 100μl 2.5% BIS (N, N′-methylene) -Bisacrylamide); 300μl DDW (double distilled water); 30μl 10% Pluronic  F127 (PF127, Poloxamer); 25μl 20% APS (ammonium persulfate); 25μl 20% TEMED (N,N,N',N'-tetramethylethylenediamine); 300μl 4% shell Glycan hydrochloride. After adding each ingredient, vortex to mix the solution. Add 120 mg of sodium bicarbonate 2 minutes before gelation occurs, vortex and shake. Place the above-mentioned super-porous hydrogel polymer containing chitosan hydrochloride in 1% glutaraldehyde-containing HCl / absolute ethanol (3:7, v / v) for 2 hours to obtain chitosan-containing Poly(acrylic acid-acrylamide) IPN-SPH of hydrochloride.

Embodiment 3

[0051] Example 3 Poly(acrylic acid-acrylamide) IPN-SPH containing chitosan trimethyl quaternary ammonium salt (TMC)

[0052] In a tall weighing bottle (40mm×25mm), add the following ingredients in sequence: 300μl 50% AM (acrylamide); 200μl 50% AA (acrylic acid); 100μl 2.5% BIS (N, N′-methylene) -Bisacrylamide); 300μl DDW (double distilled water); 30μl 10% Pluronic F127 (PF127, Poloxamer); 25μl 20% APS (ammonium persulfate); 25μl 20% TEMED (N,N,N',N'-tetramethylethylenediamine); 300μl 8% TMC . After adding each ingredient, vortex to mix the solution. Add 120 mg of sodium bicarbonate 2 minutes before gelation occurs and vortex. Place the above-mentioned superporous hydrogel polymer containing TMC in 1% glutaraldehyde-containing HCl / absolute ethanol (3:7, v / v) for 4 hours to obtain chitosan-containing trimethylquaternary ammonium Salt (TMC) poly(acrylic acid-acrylamide) IPN-SPH.

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Abstract

A super-porous aqueo-gel of an interpenetrating network polymer used for the orally applying system of protein polypeptide to suppress proteinase and break the close linking between epithelial cells contains two polymers: a cross-linked polymer and a cross-linked polyose polymer. Its preparing process includes such steps as mixing at least one unsaturated enylmonomer, at least one polyenyl cross-linking agent, a linear polyose polymer and a foaming agent to generate the super-porous aqueo-gel of semi-interpenetrating network polymer, and cross-linking with linear polyose.

Description

Technical field [0001] The invention belongs to the technical field of polymer materials, and specifically relates to an interpenetrating network polymer superporous hydrogel, a preparation method thereof, and an application in pharmacy. Background technique [0002] Hydrogel is a cross-linked hydrophilic polymer containing a network structure. It is insoluble in water, but can absorb a lot of water. The research of hydrogel began in the 1960s. Due to its biocompatibility and biodegradability, it can be widely used in the fields of medicine, biology and pharmacy. So far, many kinds of water have been invented. gel. [0003] Interpenetrating Polymer Networks (IPN) is a kind of multi-phase multi-component polymer materials. The polymer network formed by two or more kinds of polymer networks is permanently entangled between macromolecular chains (or Interpenetration) to form a unique polymer alloy, the polymer network is cross-linked, or both polymerized and cross-linked. According ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08F299/00C07K17/08A61K47/36
Inventor 印春华殷黎晨唐翠
Owner FUDAN UNIV
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