Ultra porous hydrogel complex substance, preparing method and use in pharmaceutics thereof

A technology of porous hydrogels and composites, which can be used in pharmaceutical formulations, drug delivery, and medical preparations of non-active ingredients. It can solve the problems of decreased bioadhesive protease action, and achieve fast swelling and good bioadhesion Performance, fast expansion effect

Inactive Publication Date: 2006-04-26
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the superporous hydrogel composite, due to the addition of disintegrants, makes its bioadhesion and inhibition of proteases decrease.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Embodiment 1, poly(acrylic acid and acrylamide)-carbomer superporous hydrogel composite

[0043] Add the following components to a tall weighing bottle in sequence: 300 μl 50% acrylamide; 200 μl 50% acrylic acid; 70 μl 2.5% Bis; 300 μl double distilled water; 30 μl 10% Pluronic F127; 25 μl 20% ammonium persulfate; 100 μl 0.4% Carbopol 934P; 25 μl 15% TEMED. After the addition of each component, the solution was vortex mixed, 100 mg of sodium bicarbonate was added 2 minutes before gelling, and vortexed for 20 seconds. The superporous hydrogel composite was cured at room temperature for 10 minutes and dried at 55°C for 20 hours.

Embodiment 2

[0044] Embodiment 2, poly(acrylic acid and acrylamide)-carbomer superporous hydrogel composite

[0045] Add the following ingredients to a tall weighing bottle in sequence: 300 μl 50% acrylamide; 200 μl 50% acrylic acid; 70 μl 2.5% Bis; 300 μl double distilled water; 30 μl 10% Pluronic F127; 25 μl 20% ammonium persulfate; 12 mg Carbopol 934P; 25 μl 15% TEMED. After the addition of each component, the solution was vortex mixed, 100 mg of sodium bicarbonate was added 2 minutes before gelling, and vortexed for 20 seconds. The superporous hydrogel composite was cured at room temperature for 10 minutes and dried at 55°C for 20 hours.

Embodiment 3

[0046] Embodiment 3, poly(acrylic acid and acrylamide)-carbomer superporous hydrogel composite

[0047] Add the following components to a tall weighing bottle in sequence: 300 μl 50% acrylamide; 200 μl 50% acrylic acid; 70 μl 2.5% Bis; 700 μl double distilled water; 30 μl 10% Pluronic F127; 25 μl 20% ammonium persulfate; Carbopol 934P; 25 μl 15% TEMED. After the addition of each component, the solution was vortex mixed, 100 mg of sodium bicarbonate was added 2 minutes before gelling, and vortexed for 20 seconds. The superporous hydrogel composite was cured at room temperature for 10 minutes and dried at 55°C for 20 hours.

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Abstract

The invention discloses a superporous hydrogel composite, its preparation method and its application in pharmacy. The superporous hydrogel composite of the present invention contains a crosslinked polymer and carbomer, and has a superporous structure. The polymer is formed by polymerization of at least one unsaturated ethylenic monomer and a polyene crosslinking agent. The superporous hydrogel composite of the present invention is prepared by the following steps: mixing at least one unsaturated ethylenic monomer, a polyene crosslinking agent, carbomer and a foaming agent; Formation of superporous hydrogel composites under the condition of bubbles. The superporous hydrogel complex of the present invention can be used in gastric floating preparations and protein polypeptide oral drug delivery systems. Compared with the prior art, it has bioadhesive properties and protease inhibition.

Description

technical field [0001] The invention belongs to the technical field of polymer materials, and in particular relates to a superporous hydrogel compound, its preparation method and its application in pharmacy. Background technique [0002] Hydrogels are cross-linked hydrophilic polymers containing a network structure. It is insoluble in water but absorbs large amounts of water. The study of hydrogel began in the 1960s. Due to its biocompatibility and biodegradability, it can be widely used in the fields of medicine, biology and pharmacy. So far, a variety of hydrogels have been invented. gel. [0003] As far as the swelling properties of hydrogels are concerned, they can be divided into the following two types: traditional hydrogels and new hydrogels. The most important difference between the two is their expansive nature. The swelling properties of hydrogel are mainly related to the elasticity of the network structure, the presence or absence of hydrophilic functional gro...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/00A61K47/32A61K38/16C08L33/00C08L101/14C08J9/00
Inventor 唐翠印春华
Owner FUDAN UNIV
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