38results about How to "Bioadhesive" patented technology

The invention discloses a superporous hydrogel composite, its preparation method and its application in pharmacy. The superporous hydrogel composite of the present invention contains a crosslinked polymer and carbomer, and has a superporous structure. The polymer is formed by polymerization of at least one unsaturated ethylenic monomer and a polyene crosslinking agent. The superporous hydrogel composite of the present invention is prepared by the following steps: mixing at least one unsaturated ethylenic monomer, a polyene crosslinking agent, carbomer and a foaming agent; Formation of superporous hydrogel composites under the condition of bubbles. The superporous hydrogel complex of the present invention can be used in gastric floating preparations and protein polypeptide oral drug delivery systems. Compared with the prior art, it has bioadhesive properties and protease inhibition.

The invention discloses an iron-based biochar material as well as preparation and application thereof. In the invention, by adopting nano alpha-Fe2O3 as a center substance and wrapping the nano alpha-Fe2O3 with aspergillus niger hyphe, the iron-based biochar material for arsenic-polluted soil remediation is prepared through anoxic high-temperature carbonization. The synthesized iron-based biochar material is uniformly mixed with soil according to certain proportion; and after a period of time, the fixed rate of the water-soluble state arsenic and effective-state arsenic in the arsenic-polluted soil reaches 59.6% and 66.2% respectively. The iron-based biochar material disclosed by the invention has the advantages of easiness in preparation, high efficiency without toxicity, biodegradability and no secondary pollution or damage of physicochemical properties of soil and is an environment-friendly fixing agent.

The invention discloses calcium alginate composite microspheres for stabilizing water-in-oil type Pickering emulsions and a preparation method thereof, belonging to the technical field of material polymers. Alkylsilane-grafted inorganic nanoparticles are coated on the surface of calcium alginate microspheres to form calcium alginate composite microspheres. The particle size distribution of the microspheres is 2-8 μm; it has a core-shell structure, the core is hollow, and the shell has two layers. The total thickness of the two-layer shell is 1~1.5µm, calcium alginate is the inner shell, and inorganic nanoparticles are assembled to form the outermost shell; it overcomes the fact that chitosan coated on the surface of calcium alginate microspheres can only stabilize the oil-in-water type Pickering emulsion, as a drug carrier, can only encapsulate oil-soluble drugs but not water-soluble drugs. The use of improved emulsion polymerization to prepare calcium alginate composite microspheres also has the biocompatibility of calcium alginate, Adhesion and encapsulation of protein macromolecules can stabilize the water-in-oil Pickering emulsion very well. It can widely expand the application of Pickering emulsion as a drug carrier in the fields of biomedicine, cosmetics industry, food industry and enzyme engineering.

The invention discloses a micro-occluder for cerebral aneurysm, which comprises a main body of the occluder, a filling liquid, a delivery tube, and a push catheter. A limit block is connected, and the liquid outlet end of the check valve is provided with a blocking body, the blocking body is made of biogel material with elastic deformation properties, and the filling liquid passes through the push conduit and the check valve Enter the bluff body. The parts of the invention have less dependence on the process size, and are especially suitable for small cerebral aneurysms. The filling fluid enters the blocking body through the push catheter and the check valve, so that the biogel material with elastic deformation performance can be used during the filling of the filling fluid. Elastic deformation occurs under the action, so as to expand and expand, and play the role of blocking cerebral aneurysms. The material of the blocking fluid is biogel material, which has bioadhesiveness and can successfully adhere to cerebral aneurysms, thereby Increase the strength of brain aneurysms and reduce the risk of brain aneurysm rupture.

The invention relates to a cationic adhesion type mycophenolate mofetil nano eye drop, which comprises mycophenolate mofetil of which the mass percentage concentration is 1 percent, proper amount of osmotic pressure modifying agent and pH modifying agent. The eye drop is characterized in that the eye drop also comprises chitosan, Pluronic F-68 and phospholipid, wherein the mass percentage concentration of the phospholipids in the eye drop is between 0.2 and 2 percent; the mass percentage concentration of the Pluronic F-68 in the eye drop is between 0.5 and 4 percent; the mass percentage concentration of the chitosan in the eye drop is between 0.5 and 4 percent; the molecular weight of the chitosan is between 5,000 and 300,000; the deacetylation degree is more than 85 percent; and the grain diameter of the mycophenolate mofetil is between 10 and 700 nm. The eye drop has the characteristics that: the mycophenolate mofetil with nanometer grain diameter improves the medicament solubility,the safety and the effectiveness; mycophenolate mofetil medicament particles are charged with positive charges so as to be favorable for improving the cornea absorption of the medicament, improving the medicament effect, prolonging the medicament duration, and greatly improving the cornea adhesion.