38results about How to "Bioadhesive" patented technology

The invention discloses an ultra-multiaperture hydrogel compound, making method and application in pharmacy. It contains cross-linked polymer and Carbomer. At least one unsaturated alkene monomer and polyene cross-linking agent polymerize to develop it. The making steps: mix at least one unsaturated alkene monomer, one polyene cross-linking agent, Carbomer and one foaming agent; the mixture develops it on the condition of polymerizing and foaming. It can be used in stomach floating preparation and protein polypeptide oral medicine supplying system.

A cationic adhesive-type natamycin nanometer eye drop comprises natamycin, a proper amount of osmoregulator and pH regulator. The eye drop is characterized by further comprising chitosan, pluronic F-68 and phospholipid, wherein, the mass percent concentration of the phospholipid in the eye drop is 0.01-2%, the mass percent concentration of the pluronic F-68 in the eye drop is 0.1-20%, and the mass percent concentration of the chitosan in the eye drop is 0.01-4%. The molecular weight of the chitosan is 5000-300000, and the deacetylation degree of the chitosan is greater than 85%. The natamycin nanometer eye drop is characterized by making a common natamycin suspension into suspension particles with the diameter ranging from 10nm to 1000nm, thus increasing solubility of the eye drop and enhancing safety and effectiveness. The natamycin particles of the common suspension are modified by the phospholipid and the chitosan to cause the particles to be positively charged, which is helpful to improve absorption of the eye drop by cornea, enhances drug effect and prolongs the action time of the eye drop. And the chitosan has bioadhesion function, which enhances the adhesiveness between medicinal particles and the cornea.

The invention discloses a composition for preventing and treating mucous membrane diseases with staphylococcus aureus, escherichia coli and candida albicans as pathogenic bacteria and a preparation method thereof. The composition is characterized by being prepared from the following components in percentage by mass: 0.001-35 percent of an antimicrobial agent, 0-10.0 percent of an analgesic, 0.001-20.0 percent of a bio-adhesive, 0-30.0 percent of a humectant, 0-5.0 percent of a pH regulator, 0-8.0 percent of a flavoring agent, 0-5.0 percent of an emulsifier, 0-8.0 percent of an auxiliary antimicrobial agent and the balance of pure water, totally 100 percent. The components in the composition can be well combined to achieve functions of inhibiting bacteria, isolating, relieving pain and moistening, and the effects of isolating microbial infection, preventing secondary infection and accelerating wound healing can be achieved. The composition is especially suitable for preventing and treating mucous membrane diseases in the oral cavity, nasal cavity, gastrointestinal tracts, respiratory tracts, vagina, urinary bladder, genitals, epidermis and other positions.

The invention discloses an iron-based biochar material as well as preparation and application thereof. In the invention, by adopting nano alpha-Fe2O3 as a center substance and wrapping the nano alpha-Fe2O3 with aspergillus niger hyphe, the iron-based biochar material for arsenic-polluted soil remediation is prepared through anoxic high-temperature carbonization. The synthesized iron-based biochar material is uniformly mixed with soil according to certain proportion; and after a period of time, the fixed rate of the water-soluble state arsenic and effective-state arsenic in the arsenic-polluted soil reaches 59.6% and 66.2% respectively. The iron-based biochar material disclosed by the invention has the advantages of easiness in preparation, high efficiency without toxicity, biodegradability and no secondary pollution or damage of physicochemical properties of soil and is an environment-friendly fixing agent.

The invention discloses an amphiphilic chitosan derivative drug-loaded nano-micelle and a preparation method and belongs to the field of pharmaceutical preparations. Amphiphilic chitosan derivatives form the micelle by means of self assembling, vitamin E succinate serves as a kernel, and thiolated chitosan serves as a shell; the hydrophobic kernel is used for entrapping a hydrophobic anti-HIV drug, the shell carrying positive charges is used for adsorbing cytomembrane, the loaded drug can be stably released in vivo, the hydrophilic shell is used for enhancing the solubility of the micelle and maintaining the stability of the micelle in a solution, and then the blood circulation time of the micelle after systematic administration is prolonged. The micelle can stably exist in all kinds of body fluid for more than 10 hours after particles are formed, the particle size is smaller than 200 nanometers, and it is beneficial for controlling the micelle particles to enter cells without being removed by macrophages. The delivery system can keep stability under the condition that serums exist, the drug is delivered into the cells, and good biocompatibility is achieved.

The invention provides a gynostemma pentaphylla buccal tablet and a preparation method thereof. The gynostemma pentaphylla buccal tablet comprises the following components by weight percent: 10-20% of gynostemma pentaphylla ultra-fine powder, 70-80% of mannitol, 2-6% of xylitol, 1-3% of ethanol, 0.1-0.3% of menthol, 3-5% of magnesium stearate and 0.1-0.3% of chitosan, wherein the particle size of the gynostemma pentaphylla ultra-fine powder is 1500-1800 meshes. The preparation method comprises the following steps: preparing a filler, preparing a soft material, pelleting, finishing granules, tabletting, sterilizing, packaging and the like. The gynostemma pentaphylla in the product exists in a form of ultra-fine powder; the fragrance and mouthfeel of the gynostemma pentaphylla can be maintained to the greatest extent, the effective components of the gynostemma pentaphylla can be favorably absorbed in an oral cavity; and the health-care effect of the product is greatly enhanced. The product is good in mouthfeel, has unique flavor of the gynostemma pentaphylla, a smooth surface, consistent color and luster, good hardness and good slaking characteristic, and is suitable for middle aged and elderly people, as well as people with hyperlipidemia, hyperglycemia and obesity.

The invention provides a polygonatum odoratum buccal tablet and a production method thereof. The polygonatum odoratum buccal tablet comprises the following components in parts by weight: 8-15% of polygonatum ordoratum submicron powder, 30-40% of mannitol, 33-45% of microcrystalline cellulose, 2-6% of xylitol, 1-2% of ethyl alcohol, 0.1-0.3% of menthol, 3-5% calcium sulfate and 0.1-0.3% chitosan, wherein the granularity of the polygonatum ordoratum submicron powder is 1600-1700 meshes. The production method comprises the following steps: preparing a filler, manufacturing a soft material, prilling, gathering granules, tabletting, sterilizing, and packing and the like. According to the invention, the polygonatum ordoratum can exist in the form of submicron powder, so that the fragrance and taste of the polygonatum ordoratum can be retained to the greatest extent, the effective constituent of the polygonatum ordoratum can be better absorbed inside an oral cavity, and the health care effect of products can be greatly enhanced. The polygonatum ordoratum bucaal tablet has the characteristics of being good in taste, smooth in surface, conform in color and luster, good in hardness, better in disintegrative characteristic and applicable to being taken by the middle-aged and aged people, and people with diseases of hyperlipidemia, hyperglycemia and obesity.

The invention discloses an ecological breeding feed for mutton sheep and a preparation method of the ecological breeding feed, and belongs to the technical field of feed preparation. The ecological breeding feed comprises the following raw materials of alfalfa, corn germ meal, distillers' grains DDGS, corn, middling, rice bran, bran, soybean meal, rapeseed meal, a premix feed, a microecological preparation, an additive A, an additive B and an additive C. The ecological breeding feed for mutton sheep is prepared through the steps of crushing materials, performing mixing, performing granulation,performing drying and the like. Through adoption of the prepared ecological breeding feed for mutton sheep, the average daily feed intake and the average daily gain of the mutton sheep and the digestibility of each nutrient substance can be effectively and obviously increased, and the prevalence rate can be reduced.

The invention relates to a gel ointment for treating flat wart. Carboxymethylcellulose sodium and other gels are compounded to form an ointment substrate. The carried medicaments comprise oleum fructus bruceae, gentian, isatidis root and gromwell. The gel ointment has the advantages that: 1, the ointment has function of inhibiting the growth of fungus; 2, due to the wrapping effect of a gel carrier, the medicaments are milder and avoid corrosive effect on the peripheral skin of a wart body; 3, the gel ointment can slowly and lastingly release the medical compositions, thereby improving the curative effect; 4, the ointment has biological adhesion so that the gel ointment is easy to adhere on an affected part; and 5, the gel ointment is more convenient to use.

The invention discloses a refreshing and moisturizing body lotion, belonging to the technical field of daily chemical products. The body lotion developed by the invention contains serum protein hydrolysate, bacterial cellulose, animal bone ash, an emulsifier, Carbomer, snail mucus, a thickener, taurine, nicotinamide, vitamins, 1,2-propylene glycol, plant essential oil and water, wherein the serumprotein hydrolysate is prepared by the steps of carrying out constant-temperature stirring enzymolysis on serum proteins, trypsin and water, and carrying out enzyme deactivation; the animal bone ash is prepared by the steps of crushing cow bones, and calcining with sepiolite; the bacterial cellulose is prepared by the steps of culturing acetobacter xylinum in a culture medium for 7 days, taking out, and generating a layer of gel film on the surface of the culture medium; the emulsifier is prepared by mixing non-hydrated phospholipid with tea saponin; and the thickener is prepared by mixing carrageenan, peach gum and xanthan gum. The prepared refreshing and moisturizing body lotion is light and thin in texture and has an excellent long-acting moisturizing effect.