Polygonatum odoratum buccal tablet and production method thereof

A technology of buccal tablets and Yuzhu, which is applied in the field of buccal tablets, can solve the problems of Yuzhu fragrance, taste and beneficial ingredients loss, affect the beneficial effect of Yuzhu, and the effective ingredients are not easy to penetrate and absorb, so as to achieve good disintegration performance , improve resource utilization, and improve the effect of health care

Inactive Publication Date: 2013-12-18
李嘉
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Polygonatum odoratum extract (extract) is generally used as raw material in the buccal tablets of Polygonatum odoratum on the market, which partially loses the fragrance, taste and beneficial ingredients of Polygonatum odoratum, and due to the shielding effect of the oral mucosa, its active ingredients are not easy to penetrate and absorb. Influenced the beneficial effects of Polygonatum odoratum

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Formula: Polygonatum Polygonatum Superfine Powder (1600 mesh size) 8%, Mannitol 40%, Microcrystalline Cellulose 44.8%, Xylitol 2%, Ethanol (volume concentration 70%) 1%, Menthol 0.1%, Sulfuric acid Calcium 4%, Chitosan 0.1%.

[0020] Preparation:

[0021] 1) Preparation of filler: Mix mannitol, microcrystalline cellulose, xylitol, chitosan, and calcium sulfate evenly, and pass through a 100-mesh sieve for later use;

[0022] 2) Making soft material: mix Polygonatum Polygonatum superfine powder with mannitol, microcrystalline cellulose, xylitol and chitosan after sieving, add ethanol, and stir to make soft material with moderate hardness;

[0023] 3) Granulation and granulation: pass the soft material through a 18-mesh sieve for granulation, dry it at 60°C for 2 hours, turn it once every 0.5 hours, and pass it through a 12-mesh sieve for granulation;

[0024] 4) Tablet compression: add menthol to the whole pellets, press into tablets, sterilize under ultraviolet radiat...

Embodiment 2

[0026] Formula: Polygonatum Polygonatum Superfine Powder (1700 mesh size) 15%, Mannitol 30%, Microcrystalline Cellulose 43.4%, Xylitol 5%, Ethanol (volume concentration 95%) 1%, Menthol 0.3%, Sulfuric acid Calcium 5%, chitosan 0.3%.

[0027] Preparation:

[0028] 1) Preparation of filler: Mix mannitol, microcrystalline cellulose, xylitol, chitosan, and calcium sulfate evenly, and pass through a 150-mesh sieve for later use;

[0029] 2) Making soft material: mix Polygonatum Polygonatum superfine powder with mannitol, microcrystalline cellulose, xylitol and chitosan after sieving, add ethanol, and stir to make soft material with moderate hardness;

[0030] 3) Granulation and granulation: pass the soft material through a 25-mesh sieve to granulate, dry at 80°C for 3.5 hours, turn it once every 0.5 hours, and then pass it through a 16-mesh sieve for granulation;

[0031] 4) Tablet compression: add menthol to the whole pellets, press into tablets, irradiate with ultraviolet rays ...

Embodiment 3

[0033] Formula: Polygonatum Polygonatum Superfine Powder (1650 mesh size) 10%, Mannitol 40%, Microcrystalline Cellulose 40%, Xylitol 5%, Ethanol (volume concentration 95%) 1.1%, Menthol 0.2%, Sulfuric acid Calcium 3.5%, Chitosan 0.2%.

[0034] Preparation:

[0035] 1) Preparation of filler: Mix mannitol, microcrystalline cellulose, xylitol, chitosan, and calcium sulfate evenly, and pass through a 120-mesh sieve for later use;

[0036] 2) Making soft material: Mix Polygonatum Polygonatum superfine powder with sieved mannitol, microcrystalline cellulose, xylitol and chitosan evenly, add ethanol, and stir to make soft material with moderate hardness;

[0037] 3) Granulation and granulation: Pass the soft material through a 20-mesh sieve for granulation, dry it at 70°C for 3 hours, turn it once every 0.5 hours, and pass it through a 14-mesh sieve for granulation;

[0038] 4) Tablet compression: Add menthol to the whole pellets, press into tablets, irradiate with ultraviolet ligh...

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PUM

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Abstract

The invention provides a polygonatum odoratum buccal tablet and a production method thereof. The polygonatum odoratum buccal tablet comprises the following components in parts by weight: 8-15% of polygonatum ordoratum submicron powder, 30-40% of mannitol, 33-45% of microcrystalline cellulose, 2-6% of xylitol, 1-2% of ethyl alcohol, 0.1-0.3% of menthol, 3-5% calcium sulfate and 0.1-0.3% chitosan, wherein the granularity of the polygonatum ordoratum submicron powder is 1600-1700 meshes. The production method comprises the following steps: preparing a filler, manufacturing a soft material, prilling, gathering granules, tabletting, sterilizing, and packing and the like. According to the invention, the polygonatum ordoratum can exist in the form of submicron powder, so that the fragrance and taste of the polygonatum ordoratum can be retained to the greatest extent, the effective constituent of the polygonatum ordoratum can be better absorbed inside an oral cavity, and the health care effect of products can be greatly enhanced. The polygonatum ordoratum bucaal tablet has the characteristics of being good in taste, smooth in surface, conform in color and luster, good in hardness, better in disintegrative characteristic and applicable to being taken by the middle-aged and aged people, and people with diseases of hyperlipidemia, hyperglycemia and obesity.

Description

technical field [0001] The invention relates to a buccal tablet, in particular to a Polygonatum Polygonatum buccal tablet and a preparation method thereof. Background technique [0002] Polygonatum Polygonatum is a perennial herb of Liliaceae. It is not only a vegetable but also a good medicinal material. It is often used as a Yin-tonifying medicine in traditional Chinese medicine. Its seedlings and rhizomes are edible and rich in nutrition. Polygonatum odoratum has the functions of dispelling cold, removing heat, treating falls, beautifying, and lowering blood sugar. A large number of studies have found that Yuzhu can promote the production of animal antibodies, promote the synthesis of interferon, can effectively inhibit the growth of Mycobacterium tuberculosis, can significantly increase the phagocytic index and phagocytic percentage of macrophages, and can greatly relieve the formation of arterial plaques , can also expand coronary and peripheral blood vessels, prolong ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8969A61K9/20A61K47/36A61P1/14A61P29/00A61P3/10A61P31/06A61P9/10A61P39/06A61P3/06
Inventor 李嘉
Owner 李嘉
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