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Gynostemma pentaphylla buccal tablet and preparation method thereof

A technology of Gynostemma pentaphyllum and buccal tablets, applied in the field of buccal tablets, can solve problems such as the loss of Gynostemma pentaphyllum fragrance, taste and beneficial ingredients, difficult penetration and absorption of active ingredients, and influence on Gynostemma pentaphyllum, so as to achieve good disintegration performance, improve health care effect, The effect of increasing the surface area

Inactive Publication Date: 2013-12-11
李嘉
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Gynostemma pentaphyllum buccal tablets on the market generally use Gynostemma pentaphyllum extract as raw material, so that the fragrance, taste and beneficial components of Gynostemma pentaphyllum are partially lost, and due to the shielding effect of oral mucosa, its active components are not easy to penetrate and absorb, which affects the beneficial effect of Gynostemma pentaphyllum. to play

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Ingredients: Gynostemma pentaphylla superfine powder (1600 mesh size) 8%, mannitol 84.8%, xylitol 2%, ethanol (volume fraction 50%) 1%, menthol 0.1%, magnesium stearate 4%, chitosan 0.1%.

[0021] Preparation:

[0022] 1) Preparation of filler: Mix mannitol, xylitol, and chitosan evenly, and pass through a 100-mesh sieve for later use;

[0023] 2) Preparation of soft material: Mix Gynostemma pentaphyllum superfine powder with mannitol, xylitol and chitosan after sieving, add ethanol, and stir to make soft material with moderate hardness;

[0024] 3) Granulation and granulation: pass the soft material through a 18-mesh sieve for granulation, dry it at 60°C for 2 hours, turn it every 0.5 hours, and pass it through a 12-mesh sieve for granulation;

[0025] 4) Tablet compression: add menthol to the whole pellets, then mix with magnesium stearate, press into tablets, sterilize under ultraviolet radiation for 20 minutes, pack, and obtain.

Embodiment 2

[0027] Ingredients: Gynostemma pentaphylla superfine powder (1700 mesh size) 15%, mannitol 73.4%, xylitol 5%, ethanol (volume fraction 70%) 1%, menthol 0.3%, magnesium stearate 5%, chitosan 0.3%.

[0028] Preparation:

[0029] 1) Preparation of filler: Mix mannitol, xylitol, and chitosan evenly, and pass through a 150-mesh sieve for later use;

[0030] 2) Preparation of soft material: Mix Gynostemma pentaphyllum superfine powder with mannitol, xylitol and chitosan after sieving, add ethanol, and stir to make soft material with moderate hardness;

[0031] 3) Granulation and granulation: pass the soft material through a 25-mesh sieve to granulate, dry at 80°C for 3.5 hours, turn it once every 0.5 hours, and then pass it through a 16-mesh sieve for granulation;

[0032] 4) Tablet compression: add menthol to the whole pellets, then mix with magnesium stearate, press into tablets, sterilize under ultraviolet radiation for 25 minutes, pack, and obtain.

Embodiment 3

[0034] Ingredients: Gynostemma pentaphylla superfine powder (1650 mesh size) 10%, mannitol 80%, xylitol 5%, ethanol (volume fraction 70%) 1.1%, menthol 0.2%, magnesium stearate 3.5%, chitosan 0.2%.

[0035] Preparation:

[0036] 1) Preparation of filler: Mix mannitol, xylitol, and chitosan evenly, pass through a 120-mesh sieve for later use;

[0037] 2) Preparation of soft material: Mix Gynostemma pentaphyllum superfine powder with mannitol, xylitol and chitosan after sieving, add ethanol, and stir to make soft material with moderate hardness;

[0038] 3) Granulation and granulation: pass the soft material through a 20-mesh sieve to granulate, dry at 70°C for 2.5 hours, turn it once every 0.5 hours, and then pass it through a 15-mesh sieve for granulation;

[0039] 4) Tablet compression: add menthol to the whole pellets, then mix with magnesium stearate, press into tablets, sterilize under ultraviolet radiation for 20 minutes, pack, and obtain.

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Abstract

The invention provides a gynostemma pentaphylla buccal tablet and a preparation method thereof. The gynostemma pentaphylla buccal tablet comprises the following components by weight percent: 10-20% of gynostemma pentaphylla ultra-fine powder, 70-80% of mannitol, 2-6% of xylitol, 1-3% of ethanol, 0.1-0.3% of menthol, 3-5% of magnesium stearate and 0.1-0.3% of chitosan, wherein the particle size of the gynostemma pentaphylla ultra-fine powder is 1500-1800 meshes. The preparation method comprises the following steps: preparing a filler, preparing a soft material, pelleting, finishing granules, tabletting, sterilizing, packaging and the like. The gynostemma pentaphylla in the product exists in a form of ultra-fine powder; the fragrance and mouthfeel of the gynostemma pentaphylla can be maintained to the greatest extent, the effective components of the gynostemma pentaphylla can be favorably absorbed in an oral cavity; and the health-care effect of the product is greatly enhanced. The product is good in mouthfeel, has unique flavor of the gynostemma pentaphylla, a smooth surface, consistent color and luster, good hardness and good slaking characteristic, and is suitable for middle aged and elderly people, as well as people with hyperlipidemia, hyperglycemia and obesity.

Description

technical field [0001] The invention relates to a buccal tablet, in particular to a Gynostemma pentaphyllum buccal tablet and a preparation method thereof. Background technique [0002] Gynostemma pentaphyllum, also known as five-leaf ginseng, seven-leaf gallbladder, and sweet tea vine, is a perennial herbaceous vine of Cucurbitaceae. It is cold in nature, sweet in taste, and non-toxic. Gynostemma pentaphyllum contains more than 80 kinds of gypenosides, 4 kinds of saponins are respectively related to ginsenoside Rb 1 , Rb 3 , Rd, F 2 The structure is exactly the same, wherein the content of ginsenosides is 8 times that of ginseng, and the content of total saponins is 3 times that of ginseng. Gypenoside has a similar effect to ginsenoside, and overdose has no side effects. It is a new medicinal and edible plant resource. Chinese medicine believes that Gynostemma pentaphyllum has the effects of clearing heat and detoxifying, eliminating phlegm and relieving cough, calming...

Claims

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Application Information

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IPC IPC(8): A61K36/424A61K47/36A61K9/20A61P3/06A61P3/10A61P17/02A61P35/00A61P39/00A61P39/06A61P1/16A61P37/04
Inventor 李嘉
Owner 李嘉
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