Cation adhesion type natamycin nano eye drops
A technology of natamycin and eye drops, which is applied in the field of cation-adhesive natamycin nano-eye drops, can solve the problems of limited application and difficulty in achieving sustained release of ordinary suspensions, and achieve improved safety and Effectiveness, prolonging the duration of drug action, enhancing the effect of drug efficacy
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Embodiment 1
[0022] 1.5g natamycin and 0.03mg phospholipids are dissolved in 50ml ether, and the ether is fully removed by rotary evaporation to obtain a uniformly dispersed film of medicine and phospholipids, then add 0.6% chitosan (molecular weight 5000, deacetylation degree 85%) solution 0.5ml and 0.5% F-68 solution 6ml, fully wash the membrane, ultrasonically disperse evenly to obtain an emulsion, pass the emulsion through a high-pressure homogenizer, first use 500bar pressure cycle for 5 times for initial crushing, and then use 1500bar pressure cycle for 15 times Further finely pulverized, then the homogeneous emulsion was fixed to 30ml with water for injection, the osmotic pressure was adjusted to isotonicity with sodium chloride, and the pH value of dilute hydrochloric acid was adjusted to 6.5 to obtain cationic adhesion type natamycin nanosuspension drops. eye drops. The particle size of the nanosuspension measured by the laser particle size potential analyzer is 480nm±131nm, and t...
Embodiment 2
[0024] 1.5g natamycin and 0.6g phospholipids were dissolved in 50ml ether, and the ether was fully removed by rotary evaporation to obtain a uniformly dispersed film of medicine and phospholipids, and then 1.2g chitosan and F Dissolve -686g in 25ml of water for injection and fully dissolve, fully wash the membrane with the solution of chitosan and F-68, and obtain an emulsion after ultrasonic dispersion, pass the emulsion through a high-pressure homogenizer, and first use 500bar pressure cycle 5 times for initial Pulverize, and then use 1500bar pressure cycle for 15 times to further finely pulverize, then dilute the homogeneous emulsion to 30ml with water for injection, adjust the osmotic pressure to isotonic with sodium chloride, and adjust the pH value of dilute hydrochloric acid to 6.5 to obtain cationic adhesion Natamycin Nanosuspension Eye Drops. The particle size of the nanosuspension measured by the laser particle size potential analyzer is 480nm±131nm, and the particle...
Embodiment 3
[0026] The present invention can also be obtained by replacing the chitosan in Example 1 with a chitosan with a molecular weight of 300,000 and a deacetylation degree of 85%. The particle size of the nanosuspension measured by the optical particle size potential analyzer is 530nm±186nm, and the particle surface potential is +47mV. The obtained nano-suspension was kept at 4° C. in the dark for 6 months without substantial change in particle size and potential.
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