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Ultra porous hydrogel complex substance, preparing method and use in pharmaceutics thereof

A technology of porous hydrogels and composites, which can be used in pharmaceutical formulations, drug delivery, and medical preparations of non-active ingredients. The effect of increased intensity

Inactive Publication Date: 2004-04-14
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the superporous hydrogel composite, due to the addition of disintegrants, makes its bioadhesion and inhibition of proteases decrease.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] Embodiment 1, poly(acrylic acid and acrylamide)-carbomer superporous hydrogel composite

[0054] Add the following components to a tall weighing bottle in sequence: 300 μl 50% acrylamide; 200 μl 50% acrylic acid; 70 μl 2.5% Bis; 300 μl double distilled water; 30 μl 10% Pluronic F127; 25 μl 20% ammonium persulfate; 100 μl 0.4% Carbopol 934P; 25 μl 15% TEMED. After the addition of each component, the solution was vortex mixed, 100 mg of sodium bicarbonate was added 2 minutes before gelling, and vortexed for 20 seconds. The superporous hydrogel composite was cured at room temperature for 10 minutes and dried at 55°C for 20 hours.

Embodiment 2

[0055] Embodiment 2, poly(acrylic acid and acrylamide)-carbomer superporous hydrogel composite

[0056] Add the following ingredients to a tall weighing bottle in sequence: 300 μl 50% acrylamide; 200 μl 50% acrylic acid; 70 μl 2.5% Bis; 300 μl double distilled water; 30 μl 10% Pluronic F127; 25 μl 20% ammonium persulfate; 12 mg Carbopol 934P; 25 μl 15% TEMED. After the addition of each component, the solution was vortex mixed, 100 mg of sodium bicarbonate was added 2 minutes before gelling, and vortexed for 20 seconds. The superporous hydrogel composite was cured at room temperature for 10 minutes and dried at 55°C for 20 hours.

Embodiment 3

[0057] Embodiment 3, poly(acrylic acid and acrylamide)-carbomer superporous hydrogel composite

[0058] Add the following components to a tall weighing bottle in sequence: 300 μl 50% acrylamide; 200 μl 50% acrylic acid; 70 μl 2.5% Bis; 700 μl double distilled water; 30 μl 10% Pluronic F127; 25 μl 20% ammonium persulfate; Carbopol 934P; 25 μl 15% TEMED. After the addition of each component, the solution was vortex mixed, 100 mg of sodium bicarbonate was added 2 minutes before gelling, and vortexed for 20 seconds. The superporous hydrogel composite was cured at room temperature for 10 minutes and dried at 55°C for 20 hours.

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PUM

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Abstract

The invention discloses an ultra-multiaperture hydrogel compound, making method and application in pharmacy. It contains cross-linked polymer and Carbomer. At least one unsaturated alkene monomer and polyene cross-linking agent polymerize to develop it. The making steps: mix at least one unsaturated alkene monomer, one polyene cross-linking agent, Carbomer and one foaming agent; the mixture develops it on the condition of polymerizing and foaming. It can be used in stomach floating preparation and protein polypeptide oral medicine supplying system.

Description

technical field [0001] The invention belongs to the technical field of polymer materials, and in particular relates to a superporous hydrogel compound, its preparation method and its application in pharmacy. Background technique [0002] Hydrogels are cross-linked hydrophilic polymers containing a network structure. It is insoluble in water but absorbs large amounts of water. The study of hydrogel began in the 1960s. Due to its biocompatibility and biodegradability, it can be widely used in the fields of medicine, biology and pharmacy. So far, a variety of hydrogels have been invented. gel. [0003] As far as the swelling properties of hydrogels are concerned, they can be divided into the following two types: traditional hydrogels and new hydrogels. The most important difference between the two is their expansive nature. The swelling properties of hydrogel are mainly related to the elasticity of the network structure, the presence or absence of hydrophilic functional gro...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K38/16A61K47/32C08J9/00C08L33/00C08L101/14
Inventor 唐翠印春华
Owner FUDAN UNIV
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