Thermosensitive in-situ gel preparation for norcantharidin injection and preparation method and application of thermosensitive in-situ gel preparation

The technology of norcantharidin and in-situ gel is applied in the field of thermosensitive in-situ gel preparations, which can solve the problems of unsuitable gelation temperature and poor sustained-release ability, and achieve convenient medication, reduced dosage and reduced toxicity. Effects of side effects

Active Publication Date: 2016-08-31
FIRST PEOPLES HOSPITAL OF YUHANG DISTRICT HANGZHOU
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Problems solved by technology

[0007] The invention provides a temperature-sensitive in-situ gel preparation for norcantharidin injection, which solves the problems of poor drug sustained release ability and unsuitable gelation temperature of the existing temperature-sensitive in-situ gel preparation

Method used

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  • Thermosensitive in-situ gel preparation for norcantharidin injection and preparation method and application of thermosensitive in-situ gel preparation
  • Thermosensitive in-situ gel preparation for norcantharidin injection and preparation method and application of thermosensitive in-situ gel preparation
  • Thermosensitive in-situ gel preparation for norcantharidin injection and preparation method and application of thermosensitive in-situ gel preparation

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Embodiment 1

[0045] Embodiment 1 Preparation of temperature-sensitive in situ gel preparation for norcantharidin injection

[0046] The present embodiment is a temperature-sensitive in-situ gel preparation for norcantharidin injection, the preparation method of which comprises:

[0047] (1) Accurately weigh 0.0625g norcantharidin in a 50ml beaker, add 25ml pure water and stir until dissolving, filter through a 0.45 μm microporous membrane to obtain norcantharidin solution;

[0048] (2) In another beaker, add 4.75g poloxamer 407 (Germany BASF company), 0.1g poloxamer 188 (Germany BASF company), 0.1425g polypropylene (average molecular weight is 3000Da), 0.0475g polypropylene Ethylene glycol (the average molecular weight is 5000Da), 0.02g hydroxypropyl methylcellulose (the average molecular weight is 324.2848Da) and 0.005g chitosan (the degree of deacetylation is 89%) to obtain a mixture;

[0049] (3) Pour the norcantharidin solution into the beaker of step (2), let stand, swell naturally f...

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Abstract

The invention discloses a thermosensitive in-situ gel preparation for norcantharidin injection and a preparation method and an application of the thermosensitive in-situ gel preparation. The thermosensitive in-situ gel preparation is prepared from a solvent and solute, wherein the solute is prepared from the following components by weight-to-volume ratio: 0.0025g / mL of norcantharidin, 0.19g / mL of poloxamer 407, 0.004g / mL of poloxamer 188, 0.0057g / mL of polypropylene, 0.0019g / mL of polyethylene glycol, 0.0008g / mL of hydroxypropyl methyl cellulose and 0.0002g / mL of chitosan. The gel temperature of the in-situ gel preparation is 34 DEG C, is close to the body temperature of a human body, and accords with the requirements of in vivo gel for injection; gel corrosion and drug release are carried out at a similar velocity; the drug is controlled to be slowly released by gel corrosion; the thermosensitive in-situ gel preparation has good drug slow-release and sustained-release effects; and the medication safety is good.

Description

technical field [0001] The invention relates to a temperature-sensitive in-situ gel preparation, in particular to a temperature-sensitive in-situ gel preparation for norcantharidin injection, a preparation method and application thereof. Background technique [0002] Statistics show that the incidence of cancer in my country is about 200 per 100,000 people, with more than 2.2 million new cases each year and more than 6 million patients under treatment. Among middle-aged and middle-aged people aged 35 to 59, tumors have ranked first among various causes of death. Tumor has become a major cause of the loss of the best labor force and the rise of medical expenses in our country. The current treatment methods for malignant tumors mainly include surgery, radiotherapy, chemotherapy and immunotherapy. Although these methods have a certain therapeutic effect on tumors. However, because many tumor patients are discovered at an advanced stage, they often lose the best time for surg...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K47/10A61K47/32A61K47/38A61K47/36A61K31/34A61P35/00
CPCA61K9/0002A61K9/0019A61K9/06A61K31/34A61K47/10A61K47/32A61K47/36A61K47/38
Inventor 谢明华蔡鑫君王增葛敏张越峰李小军
Owner FIRST PEOPLES HOSPITAL OF YUHANG DISTRICT HANGZHOU
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