Composition for preventing or treating mucous membrane diseases and preparation method thereof

A composition and disease technology, applied in sexual diseases, skin diseases, drug combinations, etc., can solve problems such as inability to prevent secondary infection, inability to effectively kill harmful microorganisms at the lesion site, and short residence time for drugs in the lesion.

Inactive Publication Date: 2017-01-11
王强 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] The above four documents have two deficiencies. One is that they cannot effectively kill harmful microorganisms in the lesion; the other is that the drug stays in the lesion for a short time and cannot exert its efficacy for a long time, and it cannot isolate microbial infection and prevent secondary infection. So as to achieve the effect of accelerating wound healing

Method used

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  • Composition for preventing or treating mucous membrane diseases and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029]A composition for preventing or treating mucosal diseases. In terms of mass, each component of the composition includes: the content of the antimicrobial agent component is 0.001% to 35.0%; the content of the analgesic component is 0% to 10.0%; The bioadhesive component content is 0.001%~20.0%; the moisturizing agent component content is 0%~30.0%; the pH regulator component content is 0%~5.0%; the flavoring agent component content is 0%~8.0% ﹪; emulsifier component content is 0% ~ 5.0%; auxiliary antimicrobial agent component content is 0% ~ 8.0%; the rest is purified water; the sum of each component is 100%; the antimicrobial agent is glucose chloride Hexidine, Chlorhexidine Acetate, Benzalkonium Chloride, Benzethonium Chloride, Cetrimonium Bromide, Polyhexamethyleneguanidine Salt, Cetylpyridinium Chloride, Cetylpyridinium Bromide, p-Chloro-m-Xylenol , 2,4,4'-trichloro-2'-hydroxydiphenyl ether, povidone iodine, phenol derivatives, glucose oxidase, lysozyme, hydrogen per...

Embodiment 2

[0054] In this embodiment, benzethonium chloride and xylitol are selected as the antimicrobial agent, and the component contents are 0.075% and 10.0% respectively; the analgesic component content is 0%; sodium hyaluronate is the bioadhesive agent, and the component The content is 0.2%; glycerin is the humectant, the component content is 5.0%; potassium hydroxide is the pH regulator, the component content is 0.003%, and the pH is adjusted to 6.0-8.0; the flavoring agent component content is 0%; emulsification The component content of antimicrobial agent is 0%; the content of auxiliary antimicrobial agent component is 0%; the rest is purified water.

[0055] Microbial killing effect: According to the detection method of "Disinfection Technical Specifications" in this embodiment, the stock solution acts for 3 minutes, and the killing rate of Staphylococcus aureus, Escherichia coli and Candida albicans is greater than 90%. The main pathogenic bacteria Staphylococcus aureus, Escher...

Embodiment 3

[0058] The present embodiment selects benzalkonium chloride as the antimicrobial agent, and the component content is 0.05% respectively; the analgesic component content is 0%; hydroxypropyl chitosan is the bioadhesive agent, and the component content is 4%; Glycerin is a humectant with a component content of 5.0%; potassium hydroxide is a pH regulator with a component content of 0.003% to adjust the pH to 6.0-8.0; sodium saccharin is a flavoring agent with a component content of 0.1%; emulsifier The component content is 0%; the auxiliary antimicrobial agent component content is 0%; the rest is purified water.

[0059] Microbial killing effect: In this embodiment, according to the detection method of "Disinfection Technical Specifications", the stock solution acts for 1 minute, and the killing rate of Staphylococcus aureus, Escherichia coli and Candida albicans is greater than 85%. The main pathogenic bacteria Staphylococcus aureus, Escherichia coli and Candida albicans have a ...

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Abstract

The invention discloses a composition for preventing and treating mucous membrane diseases with staphylococcus aureus, escherichia coli and candida albicans as pathogenic bacteria and a preparation method thereof. The composition is characterized by being prepared from the following components in percentage by mass: 0.001-35 percent of an antimicrobial agent, 0-10.0 percent of an analgesic, 0.001-20.0 percent of a bio-adhesive, 0-30.0 percent of a humectant, 0-5.0 percent of a pH regulator, 0-8.0 percent of a flavoring agent, 0-5.0 percent of an emulsifier, 0-8.0 percent of an auxiliary antimicrobial agent and the balance of pure water, totally 100 percent. The components in the composition can be well combined to achieve functions of inhibiting bacteria, isolating, relieving pain and moistening, and the effects of isolating microbial infection, preventing secondary infection and accelerating wound healing can be achieved. The composition is especially suitable for preventing and treating mucous membrane diseases in the oral cavity, nasal cavity, gastrointestinal tracts, respiratory tracts, vagina, urinary bladder, genitals, epidermis and other positions.

Description

technical field [0001] The invention relates to a composition and a preparation method, in particular to a composition and a preparation method for preventing and treating mucosal diseases, in particular to a method for preventing and treating pathogenic bacteria such as Staphylococcus aureus, Escherichia coli and white Composition and method of preparation for mucous membrane disease of Candida. Background technique [0002] Mucosal diseases are diseases or conditions that belong to the category of ulcers, inflammation, traumatic injury or corrosive injury, including oral ulcers (oral ulcers), cold sores, radiation-induced skin ulcers, genital tract ulcers, gastric mucosal ulcers, intestinal mucosal ulcers, actinic ulcers Keratosis, Behcet's syndrome, warts, bad breath, swollen and sore gums, etc. [0003] Such as oral disease is a common frequently-occurring disease, and the incidence rate is high, which is very harmful to human health, but it is often not taken seriously...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/00A61K31/4425A61K31/14A61K38/44A61K47/38A61K47/36A61P1/02A61P31/22A61P17/02A61P15/00A61P1/04A61P1/00A61P17/12A61P17/00A61P31/04A61P31/10A61K31/045
CPCY02A50/30
Inventor 王强徐芳辉李建和
Owner 王强
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