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Nifuratel vaginal tablet and preparation method thereof

A technology of nifuratel and vaginal tablets, which is applied in the field of medicine to achieve the effects of convenient use, long-lasting effect, and improved dissolution rate

Pending Publication Date: 2021-02-12
BEIJING CHENG JI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, there is no technology to solve the above problems of nifuratel vaginal tablets

Method used

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  • Nifuratel vaginal tablet and preparation method thereof
  • Nifuratel vaginal tablet and preparation method thereof
  • Nifuratel vaginal tablet and preparation method thereof

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Embodiment 1

[0031]

[0032]

Embodiment 2

[0034]

Embodiment 3

[0036]

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Abstract

The invention discloses a nifuratel vaginal tablet, which comprises the following components in parts by weight: 0.2-0.6 part of carbomer, 0.1-0.3 part of alginate and 1 part of nifuratel, wherein theparticle size distribution D90 of micronized nifuratel is 30-60 [mu]m. The invention also discloses a preparation method of the nifuratel vaginal tablet. According to the nifuratel vaginal tablet, the dissolution rate of the nifuratel vaginal tablet is increased by controlling nifuratel particle size distribution, the carbomer and the alginate play a role in slow release and have certain biological adhesion, so that the nifuratel vaginal tablet takes effect continuously and quickly and is not prone to falling off from the vagina, the treatment effect is guaranteed, and clothes and trousers are not polluted; and the nifuratel vaginal tablet provided by the invention is convenient to use, quick to take effect, lasting in effect and good in clinical curative effect.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a nifuratel vaginal tablet and a preparation method thereof. Background technique [0002] The Chinese invention patent with the application number "201210388820.3" provides a nifuratel composition tablet with fast disintegration and high dissolution rate and its preparation method, using sodium carboxymethyl starch and cross-linked carboxymethyl cellulose Sodium is used as a disintegrant. [0003] The Chinese invention patent with the application number "201610088985.7" provides a nifuratel solid preparation and its preparation method. The tablet using the nifuratel solid dispersion has better dissolution rate and higher bioavailability. [0004] Nifuratel vaginal tablets currently on the market have low dissolution rate, slow onset of action, low bioavailability, easy to fall off from the vagina, inconvenient clinical use and poor curative effect. [0005] The melting time a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/22A61K47/36A61K47/32A61K31/422A61P15/02
CPCA61K9/205A61K9/2027A61K9/0034A61K31/422A61P15/02
Inventor 童丰鲍勇胜
Owner BEIJING CHENG JI PHARMA
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