Biodegradable hydrogel and method for preparing same
A hydrogel and biological technology, applied in the preparation of biodegradable hydrogel, interpenetrating polymer network, biodegradable hydrogel field, to achieve the effect of mild reaction conditions, uniform macroporous structure, and rapid swelling performance
Inactive Publication Date: 2005-03-16
WUHAN UNIV
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- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
So far, there is no report on the preparation of konjac glucomannan / polyacrylic acid hydrogel by interpenetrating polymer network technology
Method used
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Experimental program
Comparison scheme
Effect test
Embodiment 1
[0016] Embodiment 1: macroporous konjac gel, which is composed of: 1.5 g of konjac fine powder, 100 mL of distilled water, and the pH value is adjusted to 13 by sodium hydroxide.
Embodiment 2
[0017] Embodiment 2: macroporous konjac gel, which is composed of: 2.5 g of konjac fine powder, 100 mL of distilled water, and the pH value is adjusted to 11 by sodium carbonate.
Embodiment 3
[0018] Embodiment 3: macroporous konjac gel, which is composed of: 3.5 g of konjac fine powder, 100 mL of distilled water, and the pH value is adjusted to 9 by sodium carbonate.
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The invention discloses a biodegradable hydrogel and method for preparing same which consists of, preparing microporous konjak gluglucosan aqueous gel, preparing refined konjaku flour, dissolving in distilled water, agitating, charging inorganic solvent, adjusting pH, carrying out crossbridging under a controlled temperature and time, water scrubbing the product yield, repeated frost thawing, freeze-drying, then swelling the konjak gluglucosan gel into the aqueous solution of acroleic acid, cross linking agent, and initiating agent, carrying out polymerization under a controlled temperature and time, and water scrubbing the obtained outcome yield.
Description
technical field [0001] The present invention relates to the field of biomedical polymer materials, more specifically to a biodegradable hydrogel, and also to a preparation method of the biodegradable hydrogel, which is composed of konjac glucomannan hot-alkali cross-linked, freeze-thawed Process the resulting gel with an interpenetrating polymer network composed of polyacrylic acid. Background technique [0002] Polymer hydrogel is a body-shaped network of hydrophilic polymers that can swell in water and retain a large amount of water without dissolving. The many uses of hydrogels in the fields of biochemistry, medicine, agriculture, and daily chemical industry have aroused the general attention of scientists. Polyacrylic acid hydrogel is a widely used synthetic polymer material with pH responsiveness, and has a good application prospect in oral pharmaceutical preparations. However, its non-biodegradability limits its application in biomedicine. ...
Claims
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IPC IPC(8): C08F251/00C08J3/075
Inventor 刘芝兰胡菡卓仁禧
Owner WUHAN UNIV
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