Active oxygen-eliminating antibacterial and anti-inflammatory hydrogel skin dressing and preparation method thereof

An antibacterial, anti-inflammatory, and hydrogel technology, applied in medical science, bandages, etc., can solve problems such as difficult storage, poor mechanical properties of hydrogels, and limitations

Active Publication Date: 2021-11-02
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The antibacterial properties of such hydrogels usually rely on natural macromolecules with antibacterial properties such as chitosan, but the hydrogels prepared from natural molecules have poor mechanical properties and are not easy to store; or rely on traditional antibio

Method used

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  • Active oxygen-eliminating antibacterial and anti-inflammatory hydrogel skin dressing and preparation method thereof
  • Active oxygen-eliminating antibacterial and anti-inflammatory hydrogel skin dressing and preparation method thereof
  • Active oxygen-eliminating antibacterial and anti-inflammatory hydrogel skin dressing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028]The first step: under nitrogen protection, 25.5g polyethylene glycol methyl ether methacrylate monomer (Mn=300), 6.4g glycidyl methacrylate monomer and 3.3g azobisisobutyronitrile were dissolved in 300ml In methanol solvent, magnetically stirred, heated to reflux at 70 degrees Celsius for 10 hours; after the reaction, the reaction solution was precipitated in glacial ether, the product was collected by centrifugation, and the crude product was obtained after drying; the crude product was dissolved in methanol, and then settled in glacial ether to remove Miscellaneous, collect product after repeating three times, vacuum drying obtains poly(polyethylene glycol methyl ether methacrylate-co-glycidyl methacrylate);

[0029] The second step: 0.8g of poly(polyethylene glycol methyl ether methacrylate-co-glycidyl methacrylate) prepared in the first step, 82.8mg of acetone [bis-(2-amino-ethyl)- Dithiol] and 51.4mg 3,3'-dithiobis(propionyl hydrazide) were dissolved in 4ml 0.5wt% p...

Embodiment 2

[0035] The first step: under nitrogen protection, 14.17g polyethylene glycol methyl ether methacrylate monomer (Mn=300), 3.56g glycidyl methacrylate monomer and 1.60g azobisisobutyronitrile were dissolved in 100ml In methanol solvent, magnetically stirred, heated to reflux at 70°C for 10 h; precipitated the reaction solution in glacial ether, centrifuged to collect the product, and dried to obtain a crude product; dissolved the crude product in methanol, then settled in glacial ether to remove impurities, and repeated After three times, the product was collected and vacuum-dried to obtain poly(polyethylene glycol methyl ether methacrylate-co-glycidyl methacrylate);

[0036] The second step: 0.2g of poly(polyethylene glycol methyl ether methacrylate-co-glycidyl methacrylate) prepared in the first step, 12.9mg of acetone [bis-(2-amino-ethyl)- Dithiol] and 22.5mg 3,3'-dithiobis(propionyl hydrazide) were dissolved in 1ml 1wt% polyvinyl alcohol solution to obtain a hydrogel prepoly...

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Abstract

The invention relates to an active oxygen elimination antibacterial and anti-inflammatory hydrogel skin dressing and a preparation method thereof. The skin dressing is prepared by the ring-opening reaction of amino of acetone [bis-(2-amino-ethyl)-dithioalcohol] and 3,3'-dithiobis(propionohydrazide) with epoxy groups of poly (polyethylene glycol methyl ether methacrylate-co-glycidyl methacrylate) to form a main body hydrogel network, and meanwhile, polyvinyl alcohol chain segments are inserted into the hydrogel network to form a semi-interpenetrating network; the freeze-dried hydrogel is swelled in a hyperbranched polylysine solution to realize loading of antibacterial substances, so that the active oxygen eliminating antibacterial and anti-inflammatory hydrogel skin dressing can be obtained. The antibacterial and anti-inflammatory hydrogel skin dressing capable of eliminating active oxygen can be used for repairing skin injury, has broad-spectrum antibacterial and bacteriostatic effects, can achieve the effects of regulating and controlling the inflammation level of a wound part, promoting wound healing and reducing scar generation by eliminating excessive active oxygen at the wound part, and does not generate drug resistance.

Description

technical field [0001] The invention relates to a medical antibacterial dressing for promoting skin wound repair, in particular to an active oxygen eliminating antibacterial and anti-inflammatory hydrogel skin dressing and a preparation method thereof. Background technique [0002] The skin is the largest organ of the human body, and it plays a huge role in protecting the human body, preventing microbial invasion, and maintaining body fluid balance. Skin trauma is the most common lesion in people's daily life, especially full-thickness skin defect wounds, which require a long healing and recovery time. There are four stages in the repair process of skin wounds: the hemostatic stage, the inflammatory stage, the proliferative stage and the remodeling stage, and it usually takes several months for complete healing. Moderate inflammation can activate the immune system, remove necrotic tissue, and play a decisive role in the speed of wound healing, the degree of scarring, and th...

Claims

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Application Information

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IPC IPC(8): A61L26/00C08J3/075C08J3/24C08L51/08
Inventor 高长有涂辰兮周同
Owner ZHEJIANG UNIV
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