Active oxygen-eliminating antibacterial and anti-inflammatory hydrogel skin dressing and preparation method thereof

Abstract

The invention relates to an active oxygen elimination antibacterial and anti-inflammatory hydrogel skin dressing and a preparation method thereof. The skin dressing is prepared by the ring-opening reaction of amino of acetone [bis-(2-amino-ethyl)-dithioalcohol] and 3,3'-dithiobis(propionohydrazide) with epoxy groups of poly (polyethylene glycol methyl ether methacrylate-co-glycidyl methacrylate) to form a main body hydrogel network, and meanwhile, polyvinyl alcohol chain segments are inserted into the hydrogel network to form a semi-interpenetrating network; the freeze-dried hydrogel is swelled in a hyperbranched polylysine solution to realize loading of antibacterial substances, so that the active oxygen eliminating antibacterial and anti-inflammatory hydrogel skin dressing can be obtained. The antibacterial and anti-inflammatory hydrogel skin dressing capable of eliminating active oxygen can be used for repairing skin injury, has broad-spectrum antibacterial and bacteriostatic effects, can achieve the effects of regulating and controlling the inflammation level of a wound part, promoting wound healing and reducing scar generation by eliminating excessive active oxygen at the wound part, and does not generate drug resistance.

Description

technical field [0001] The invention relates to a medical antibacterial dressing for promoting skin wound repair, in particular to an active oxygen eliminating antibacterial and anti-inflammatory hydrogel skin dressing and a preparation method thereof. Background technique [0002] The skin is the largest organ of the human body, and it plays a huge role in protecting the human body, preventing microbial invasion, and maintaining body fluid balance. Skin trauma is the most common lesion in people's daily life, especially full-thickness skin defect wounds, which require a long healing and recovery time. There are four stages in the repair process of skin wounds: the hemostatic stage, the inflammatory stage, the proliferative stage and the remodeling stage, and it usually takes several months for complete healing. Moderate inflammation can activate the immune system, remove necrotic tissue, and play a decisive role in the speed of wound healing, the degree of scarring, and th...

AI Technical Summary

Problems solved by technology

The antibacterial properties of such hydrogels usually rely on natural macromolecules with antibacterial properties such as chitosan, but the hydrogels prepared from natural molecules have poor mechanical properties and are not easy to store; or rely on traditional antibiotics to achieve antibacterial, which is easy to produce bacteria Drug resistance; there are also antibacterial systems based on metals such as silver, copper and their nanoparticles, which have biological safety risks and their applications are limited to a certain extent

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