17 results about "Dermal dressing" patented technology

The invention is suitable for the technical field of skin dressings, and provides preparation and application of a polyphenol nano-liposome loaded i-PRF skin dressing, the skin dressing comprises oxidized sodium alginate, carboxymethyl chitosan, freeze-dried concentrated growth factors and oleuropein nano-liposomes, the concentration of the oxidized sodium alginate is 0.2-0.5 g / ml, the concentration of the carboxymethyl chitosan is 0.2-0.5 g / ml, the concentration of the freeze-dried concentrated growth factors is 0.2-0.5 g / ml, and the concentration of the oleuropein nano-liposomes is 0.2-0.5 g / ml. The concentration of the carboxymethyl chitosan is 0.2 to 0.5 g / ml, the concentration of the freeze-dried concentrated growth factor is 0.05 to 0.1 g / ml, and the concentration of the oleuropein nano-liposome is 0.125 to 1 ml / g. According to the skin dressing, the biocompatibility of the hydrogel is effectively improved, the sustained drug sustained release characteristic is shown, and the skin dressing has outstanding performance in the aspect of promoting wound healing.

The invention discloses spirulina extracellular vesicle hydrogel as well as a preparation method and application thereof. The spirulina extracellular vesicle hydrogel is prepared by separating spirulina extracellular vesicles and loading the spirulina extracellular vesicles on sodium alginate / carboxymethyl chitosan hydrogel, and the method is low in cost, simple, feasible, green and safe. Skin tissue lesions caused by ultraviolet radiation can be effectively prevented and treated by externally applying the hydrogel, and the skin tissue lesions comprise abnormal epidermis thickening, collagenous fiber loss and disorder and the like; skin oxidative stress caused by ultraviolet is inhibited, and the anti-oxidation effect is achieved; the skin inflammation caused by ultraviolet is relieved by inhibiting the generation of proinflammatory factors; as a skin dressing, transdermal noninvasive administration can be realized; good biological safety is shown. The method has a wide application prospect in prevention and treatment of skin ultraviolet injury related diseases by using bioactive materials.

The invention relates to the field of biological dressings, and discloses an artificial dermis dressing as well as a preparation method and application thereof. The preparation method comprises the following steps: adding water into a container, and freezing until the water is frozen; then adding a collagen A solution, freezing and standing; continuing to add collagen B liquid, freezing and standing; continuing to add collagen A liquid, freezing and then freeze-drying; and cross-linking in a glutaraldehyde solution, and cleaning to obtain the artificial dermis dressing. The dressing provided by the invention can provide a good stent effect and promote cell migration and proliferation, and the healing rate is close to 100% after wound making. In the wound healing process, the dressing can inhibit collagen deposition, relieve inflammatory response, inhibit abnormal hyperplasia of blood vessels, inhibit excessive proliferation of fibroblasts and excessive formation of granulation tissues, and effectively prevent scar formation. The dressing can also effectively inhibit abnormal vascular hyperplasia in a wound area, and fibrosis and scar hyperplasia caused by excessive vascular hyperplasia are prevented.

The invention belongs to the technical field of skin dressing. The invention provides an antioxidant, antibacterial and moisturizing patterned treatment skin dressing and a preparation method thereof, and the preparation method comprises the following steps: (1) preparing a polymer solution from a mixture of chitosan and polyvinyl alcohol as a shell solution; mixing the active component into a polyethylene glycol aqueous solution to serve as a core layer solution; and (2) taking a glass plate with gully patterning as a receiving plate, performing coaxial electrostatic spinning on the shell layer solution and the core layer solution obtained in the step (1), and preparing a fiber membrane to obtain the skin dressing, wherein the active ingredients comprise vitamin E, celery seed aqueous extract and edible amaranth aqueous extract in a weight ratio of 1: 1: (1-2). The obtained dressing has excellent oxidation resistance, antibacterial property and moisture retention, the healing time of burn wounds can be greatly shortened, and the dressing has good industrial application prospects.

The invention provides a preparation method of traditional Chinese medicine hydrogel for treating psoriasis, the hydrogel preparation is prepared from the following raw material medicines in parts by weight: 20-40 parts of PVA, 60-80 parts of borax, 20-40 parts of glycyrrhizic acid, 8-12 parts of paeoniflorin and 2-3 parts of glycerin, the hydrogel has the advantages of injectability, self-healing, stretchability and the like, can meet the requirements of skin dressing, can be tightly attached to the skin, and has a good application prospect. The separation is easy. Animal experiments prove that after being loaded with paeoniflorin, the gel has the curative effect of treating mild and moderate psoriasis, the treatment effect is remarkable, and the gel has a wide market application prospect.

The invention provides self-healing hyaluronic acid-gelatin hydrogel as well as a preparation method and application thereof, and belongs to the technical field of hydrogel. According to the invention, modifiable sites of hyaluronic acid and gelatin are modified, and phenylboronic acid modified hyaluronic acid and caffeic acid modified gelatin are chemically crosslinked through boric acid ester to form the hydrogel, so that the problem of insufficient adhesive force of hyaluronic acid and gelatin is solved, and meanwhile, the hydrogel has self-healing ability to adapt to constantly changing wound tissues; the epigallocatechin gallate is introduced into a hydrogel system, so that the hydrogel has excellent biocompatibility and good oxidation resistance at the same time. In addition, the preparation method provided by the invention is mild in reaction condition and simple and convenient to operate, and can be widely applied to the fields of skin dressings, tissue processes and the like.

The invention relates to a skin dressing and a preparation method, the skin dressing comprises an external dressing patch and a dressing solution, and the dressing solution is added to the external dressing patch, the dressing solution is prepared from the following components in parts by weight: 1.5 to 2.5 parts of a solvent, 60.8 to 62.8 parts of a film forming agent, 20.8 to 23.6 parts of an antioxidant, 9.8 to 11.3 parts of a humectant, 2.1 to 2.8 parts of a skin conditioning agent, 0.32 to 0.51 part of a thickening agent and 0.18 to 0.23 part of a penetration enhancer, and 0.39 to 0.58 parts by weight of a soothing agent. The skin dressing can solve the problems of insufficient drug loading capacity and small range in the traditional technology, for example, drug loading capacity research is carried out on traditional Chinese medicine extract, traditional Chinese medicine powder and chemical drugs, the maximum drug loading capacity reaches 30% or above and is increased by 2-3 times compared with a traditional patch, and the requirement for high drug loading capacity is met.

The invention belongs to the technical field of skin dressings, and particularly relates to a composite hydrogel for promoting wound healing and a preparation method thereof. The composite hydrogel for promoting wound healing comprises the following raw materials in parts by weight: 60-80 parts of a composite core, 3-8 parts of I-type collagen, 8-15 parts of gelatin and 8-15 parts of an inclusion compound, a natural biological base material is adopted as a core carrier, the stability and activity of functional components are improved through a clathrate compound technology, the outer layer accurately removes inflammation stress and provides antibacterial protection through oxidation sensitivity characteristics, the middle layer directionally recruits endogenous stem cells through active peptide to activate the repair potential, and the anti-inflammatory effect is achieved. The composite inner core guides ordered deposition of collagen through a bionic structure to achieve scar repair, and the wound healing quality is remarkably improved.

The present invention belongs to the technical field of skin dressings. The present invention provides a patterned skin dressing with antioxidant, antibacterial and moisturizing properties and a preparation method thereof, the preparation method comprising the following steps: (1) preparing a polymer solution with a mixture of chitosan and polyvinyl alcohol as a shell solution; mixing active ingredients into a polyethylene glycol aqueous solution as a core solution; (2) using a glass plate with a groove pattern as a receiving plate, coaxially electrospinning the shell solution and the core solution obtained in step (1) to prepare a fiber membrane to obtain the skin dressing; wherein the active ingredients include vitamin E, celery seed water extract and amaranth water extract in a weight ratio of 1:1:1 to 2. The dressing obtained by the present invention has excellent antioxidant, antibacterial and moisturizing properties, can also significantly shorten the healing time of burn wounds, and has good industrial application prospects.

The invention discloses a multifunctional lignin hydrogel for skin dressing and a preparation method thereof. The preparation method of the multifunctional lignin hydrogel comprises the following steps: dissolving curcumin powder and alkali lignin powder in a NaOH solution according to a certain ratio, slowly dropwise adding the curcumin powder and the alkali lignin powder into an isometric silver ammonia solution, reacting for 30-60 minutes at room temperature, adding a certain amount of nudianin, 2.7 g of acrylamide, 0.3 g of acrylic acid and 3 mg of N, N-dimethyl formamide, and reacting for 30-60 minutes at room temperature to obtain the multifunctional lignin hydrogel. The lignin-curcumin silver nanoparticle-poly (acrylamide-acrylic acid) hydrogel loaded with the nudianin is obtained by jointly dissolving the lignin, the N, N-methylene bisacrylamide and 45 mg of ammonium persulfate in a dispersion liquid of the nanoparticles, stirring to prepare a uniform solution, and standing for 20-30 minutes at room temperature to obtain the lignin-curcumin silver nanoparticle-poly (acrylamide-acrylic acid) hydrogel loaded with the nudianin. The multifunctional lignin hydrogel prepared by the invention has multiple functions of adhesion, antibiosis, antioxidation, hemostasis and the like, can be used for accelerating skin wound healing, and has a better application prospect in skin dressings.

The invention belongs to the technical field of skin dressings, and particularly relates to an eggshell membrane oxidation regenerated cellulose nanofiber membrane and a preparation method and application thereof. The preparation method comprises the following steps: preparing a substrate film layer from a substrate spinning solution by adopting a microfluidic gas jet spinning method; preparing the composite spinning solution on the surface of the substrate fiber membrane by adopting a microfluidic gas jet spinning method to obtain a medicine-containing membrane layer; the eggshell membrane oxidation regenerated cellulose nanofiber membrane is composed of the base membrane layer and the medicine-containing membrane layer. According to the eggshell membrane oxidized regenerated cellulose nanofiber membrane obtained by the preparation method provided by the invention, the dissolution rate and bioavailability of a medicine are remarkably improved, and the preparation method has excellent process reproducibility, so that the stability of product quality and the consistency between batches are ensured; and a reliable technical support is provided for industrial production of the eggshell membrane oxidation regenerated cellulose nanofiber membrane as a skin auxiliary material.

The utility model provides a dressing fitting degree adjusting device, which belongs to the technical field of adjusting devices, and comprises a soft plate and an adjusting mechanism, the adjusting mechanism is arranged on the outer side of the soft plate, the adjusting mechanism comprises a battery module, a thin pump, a sensing control module, a connecting hose, a connecting block and an airtight patch, the battery module is fixedly arranged on the top of the soft plate, and the thin pump is arranged on the thin pump. And the thin pump is fixedly mounted at the top of the battery module. Through the arrangement of the adjusting mechanism, a proper amount of air is injected into the airtight patch through the thin pump to achieve the tight attaching effect, the pressure between the airtight patch and the skin surface can be adjusted, the comfortable effect is achieved, through the arrangement of the fixing mechanism, an inserting buckle and an inserting rod are fixed, and the fixing effect is good. The dressings in various forms can be fixed on the skin at various positions of the body, the fitting degree of the skin dressings can be greatly improved, the length can be adjusted by matching the limiting rod with the adjusting hole, and the dressing fixing device is suitable for different positions of the body.

A cover skin wrap (100), for use with cream (20) on skin (10) is provided. The object of the invention is achieved using a sealing layer on a base layer.

The present invention discloses a multifunctional lignin hydrogel for skin dressings and a preparation method thereof. The multifunctional lignin hydrogel is prepared by first dissolving curcumin powder and alkali lignin powder in a NaOH solution in a certain proportion, slowly adding the solution dropwise to an equal volume of silver ammonia solution, and reacting at room temperature for 30 to 60 minutes. A certain amount of nudiflorin, 2.7 g acrylamide, 0.3 g acrylic acid, 3 mg N,N-methylenebisacrylamide, and 45 mg ammonium persulfate are then dissolved in a dispersion of the nanoparticles described above, stirred to form a uniform solution, and allowed to stand at room temperature for 20 to 30 minutes to obtain a nudiflorin-loaded lignin-curcumin silver nanoparticle-poly(acrylamide-acrylic acid) hydrogel. The multifunctional lignin hydrogel prepared by the present invention has multiple functions, including adhesion, antibacterial, antioxidant, and hemostatic properties. It can be used to accelerate skin wound healing and has good application prospects in skin dressings.

The invention relates to a cell membrane and a corresponding medical repair material as well as a preparation method and application thereof. The extraction method of the mesenchymal stem cell membrane comprises the following steps: carrying out cracking, ultrasonication and centrifugation on mesenchymal stem cells to obtain the mesenchymal stem cell membrane. The mesenchymal stem cell membrane can promote wound healing and damage repair of skin barriers, and can be used for preparing skin dressings, medicines for treating wound healing and cosmetics. The obtained mesenchymal stem cell membrane can be used as an effective component for treating wounds and repairing skin, a new situation that the cell membrane is applied to wound healing treatment and skin repairing is developed, and a new choice is provided for skin dressing, wound healing drugs and cosmetics.

The present invention belongs to the field of human body care technology, and discloses an oligomeric agarose sol, a preparation method, and an application thereof. The oligomeric agarose sol provided by the present invention is in the form of an opaque semi-fluid colloid or a solidified colloid at room temperature, and the degree of polymerization n is 2 to 10,000. The oligomeric agarose sol with such a special form and a specific degree of polymerization enables the polymer to have excellent moisturizing ability and the ability to promote the healing of micro-wounds. It can be used as a moisturizing ingredient in cosmetics, and has an excellent moisturizing effect regardless of whether it is in a high humidity environment or a dry environment, and has a significant effect on improving the expression of filaggrin in human keratinocytes; in the field of medical dressings, it can be used as a skin dressing to promote the healing of micro-wounds. Therefore, the oligomeric agarose sol provided by the present invention has a high application value as a bioactive substance.