23 results about "Dermal dressing" patented technology

The invention is suitable for the technical field of skin dressings, and provides preparation and application of a polyphenol nano-liposome loaded i-PRF skin dressing, the skin dressing comprises oxidized sodium alginate, carboxymethyl chitosan, freeze-dried concentrated growth factors and oleuropein nano-liposomes, the concentration of the oxidized sodium alginate is 0.2-0.5 g / ml, the concentration of the carboxymethyl chitosan is 0.2-0.5 g / ml, the concentration of the freeze-dried concentrated growth factors is 0.2-0.5 g / ml, and the concentration of the oleuropein nano-liposomes is 0.2-0.5 g / ml. The concentration of the carboxymethyl chitosan is 0.2 to 0.5 g / ml, the concentration of the freeze-dried concentrated growth factor is 0.05 to 0.1 g / ml, and the concentration of the oleuropein nano-liposome is 0.125 to 1 ml / g. According to the skin dressing, the biocompatibility of the hydrogel is effectively improved, the sustained drug sustained release characteristic is shown, and the skin dressing has outstanding performance in the aspect of promoting wound healing.

The invention discloses spirulina extracellular vesicle hydrogel as well as a preparation method and application thereof. The spirulina extracellular vesicle hydrogel is prepared by separating spirulina extracellular vesicles and loading the spirulina extracellular vesicles on sodium alginate / carboxymethyl chitosan hydrogel, and the method is low in cost, simple, feasible, green and safe. Skin tissue lesions caused by ultraviolet radiation can be effectively prevented and treated by externally applying the hydrogel, and the skin tissue lesions comprise abnormal epidermis thickening, collagenous fiber loss and disorder and the like; skin oxidative stress caused by ultraviolet is inhibited, and the anti-oxidation effect is achieved; the skin inflammation caused by ultraviolet is relieved by inhibiting the generation of proinflammatory factors; as a skin dressing, transdermal noninvasive administration can be realized; good biological safety is shown. The method has a wide application prospect in prevention and treatment of skin ultraviolet injury related diseases by using bioactive materials.

The invention relates to the field of biological dressings, and discloses an artificial dermis dressing as well as a preparation method and application thereof. The preparation method comprises the following steps: adding water into a container, and freezing until the water is frozen; then adding a collagen A solution, freezing and standing; continuing to add collagen B liquid, freezing and standing; continuing to add collagen A liquid, freezing and then freeze-drying; and cross-linking in a glutaraldehyde solution, and cleaning to obtain the artificial dermis dressing. The dressing provided by the invention can provide a good stent effect and promote cell migration and proliferation, and the healing rate is close to 100% after wound making. In the wound healing process, the dressing can inhibit collagen deposition, relieve inflammatory response, inhibit abnormal hyperplasia of blood vessels, inhibit excessive proliferation of fibroblasts and excessive formation of granulation tissues, and effectively prevent scar formation. The dressing can also effectively inhibit abnormal vascular hyperplasia in a wound area, and fibrosis and scar hyperplasia caused by excessive vascular hyperplasia are prevented.

The invention belongs to the technical field of skin dressing. The invention provides an antioxidant, antibacterial and moisturizing patterned treatment skin dressing and a preparation method thereof, and the preparation method comprises the following steps: (1) preparing a polymer solution from a mixture of chitosan and polyvinyl alcohol as a shell solution; mixing the active component into a polyethylene glycol aqueous solution to serve as a core layer solution; and (2) taking a glass plate with gully patterning as a receiving plate, performing coaxial electrostatic spinning on the shell layer solution and the core layer solution obtained in the step (1), and preparing a fiber membrane to obtain the skin dressing, wherein the active ingredients comprise vitamin E, celery seed aqueous extract and edible amaranth aqueous extract in a weight ratio of 1: 1: (1-2). The obtained dressing has excellent oxidation resistance, antibacterial property and moisture retention, the healing time of burn wounds can be greatly shortened, and the dressing has good industrial application prospects.

The invention provides a preparation method of traditional Chinese medicine hydrogel for treating psoriasis, the hydrogel preparation is prepared from the following raw material medicines in parts by weight: 20-40 parts of PVA, 60-80 parts of borax, 20-40 parts of glycyrrhizic acid, 8-12 parts of paeoniflorin and 2-3 parts of glycerin, the hydrogel has the advantages of injectability, self-healing, stretchability and the like, can meet the requirements of skin dressing, can be tightly attached to the skin, and has a good application prospect. The separation is easy. Animal experiments prove that after being loaded with paeoniflorin, the gel has the curative effect of treating mild and moderate psoriasis, the treatment effect is remarkable, and the gel has a wide market application prospect.

The invention provides self-healing hyaluronic acid-gelatin hydrogel as well as a preparation method and application thereof, and belongs to the technical field of hydrogel. According to the invention, modifiable sites of hyaluronic acid and gelatin are modified, and phenylboronic acid modified hyaluronic acid and caffeic acid modified gelatin are chemically crosslinked through boric acid ester to form the hydrogel, so that the problem of insufficient adhesive force of hyaluronic acid and gelatin is solved, and meanwhile, the hydrogel has self-healing ability to adapt to constantly changing wound tissues; the epigallocatechin gallate is introduced into a hydrogel system, so that the hydrogel has excellent biocompatibility and good oxidation resistance at the same time. In addition, the preparation method provided by the invention is mild in reaction condition and simple and convenient to operate, and can be widely applied to the fields of skin dressings, tissue processes and the like.

The invention relates to a skin dressing and a preparation method, the skin dressing comprises an external dressing patch and a dressing solution, and the dressing solution is added to the external dressing patch, the dressing solution is prepared from the following components in parts by weight: 1.5 to 2.5 parts of a solvent, 60.8 to 62.8 parts of a film forming agent, 20.8 to 23.6 parts of an antioxidant, 9.8 to 11.3 parts of a humectant, 2.1 to 2.8 parts of a skin conditioning agent, 0.32 to 0.51 part of a thickening agent and 0.18 to 0.23 part of a penetration enhancer, and 0.39 to 0.58 parts by weight of a soothing agent. The skin dressing can solve the problems of insufficient drug loading capacity and small range in the traditional technology, for example, drug loading capacity research is carried out on traditional Chinese medicine extract, traditional Chinese medicine powder and chemical drugs, the maximum drug loading capacity reaches 30% or above and is increased by 2-3 times compared with a traditional patch, and the requirement for high drug loading capacity is met.

The invention belongs to the technical field of skin dressings, and particularly relates to a composite hydrogel for promoting wound healing and a preparation method thereof. The composite hydrogel for promoting wound healing comprises the following raw materials in parts by weight: 60-80 parts of a composite core, 3-8 parts of I-type collagen, 8-15 parts of gelatin and 8-15 parts of an inclusion compound, a natural biological base material is adopted as a core carrier, the stability and activity of functional components are improved through a clathrate compound technology, the outer layer accurately removes inflammation stress and provides antibacterial protection through oxidation sensitivity characteristics, the middle layer directionally recruits endogenous stem cells through active peptide to activate the repair potential, and the anti-inflammatory effect is achieved. The composite inner core guides ordered deposition of collagen through a bionic structure to achieve scar repair, and the wound healing quality is remarkably improved.

The present invention belongs to the technical field of skin dressings. The present invention provides a patterned skin dressing with antioxidant, antibacterial and moisturizing properties and a preparation method thereof, the preparation method comprising the following steps: (1) preparing a polymer solution with a mixture of chitosan and polyvinyl alcohol as a shell solution; mixing active ingredients into a polyethylene glycol aqueous solution as a core solution; (2) using a glass plate with a groove pattern as a receiving plate, coaxially electrospinning the shell solution and the core solution obtained in step (1) to prepare a fiber membrane to obtain the skin dressing; wherein the active ingredients include vitamin E, celery seed water extract and amaranth water extract in a weight ratio of 1:1:1 to 2. The dressing obtained by the present invention has excellent antioxidant, antibacterial and moisturizing properties, can also significantly shorten the healing time of burn wounds, and has good industrial application prospects.

The invention belongs to the field of medical biological materials, and particularly relates to preparation and application of an antibacterial and anti-inflammatory fibrous membrane skin dressing. The invention provides a fibrous membrane skin dressing, the fibrous membrane skin dressing is fiber coated with tannic acid TA and polylysine PLys, the polylysine PLys is grafted to carboxyl of the tannic acid TA through EDC / NHS mediated amide condensation reaction, and the selected bioactive polylysine cooperates with the tannic acid to play a stronger antibacterial effect. Meanwhile, the fibrous membrane skin dressing disclosed by the invention is well applied to skin dressings for preventing bacterial infection of wounds, reducing inflammatory response of the wounds and promoting healing of the wounds.

The invention discloses a multifunctional lignin hydrogel for skin dressing and a preparation method thereof. The preparation method of the multifunctional lignin hydrogel comprises the following steps: dissolving curcumin powder and alkali lignin powder in a NaOH solution according to a certain ratio, slowly dropwise adding the curcumin powder and the alkali lignin powder into an isometric silver ammonia solution, reacting for 30-60 minutes at room temperature, adding a certain amount of nudianin, 2.7 g of acrylamide, 0.3 g of acrylic acid and 3 mg of N, N-dimethyl formamide, and reacting for 30-60 minutes at room temperature to obtain the multifunctional lignin hydrogel. The lignin-curcumin silver nanoparticle-poly (acrylamide-acrylic acid) hydrogel loaded with the nudianin is obtained by jointly dissolving the lignin, the N, N-methylene bisacrylamide and 45 mg of ammonium persulfate in a dispersion liquid of the nanoparticles, stirring to prepare a uniform solution, and standing for 20-30 minutes at room temperature to obtain the lignin-curcumin silver nanoparticle-poly (acrylamide-acrylic acid) hydrogel loaded with the nudianin. The multifunctional lignin hydrogel prepared by the invention has multiple functions of adhesion, antibiosis, antioxidation, hemostasis and the like, can be used for accelerating skin wound healing, and has a better application prospect in skin dressings.

The invention belongs to the technical field of skin dressings, and particularly relates to an eggshell membrane oxidation regenerated cellulose nanofiber membrane and a preparation method and application thereof. The preparation method comprises the following steps: preparing a substrate film layer from a substrate spinning solution by adopting a microfluidic gas jet spinning method; preparing the composite spinning solution on the surface of the substrate fiber membrane by adopting a microfluidic gas jet spinning method to obtain a medicine-containing membrane layer; the eggshell membrane oxidation regenerated cellulose nanofiber membrane is composed of the base membrane layer and the medicine-containing membrane layer. According to the eggshell membrane oxidized regenerated cellulose nanofiber membrane obtained by the preparation method provided by the invention, the dissolution rate and bioavailability of a medicine are remarkably improved, and the preparation method has excellent process reproducibility, so that the stability of product quality and the consistency between batches are ensured; and a reliable technical support is provided for industrial production of the eggshell membrane oxidation regenerated cellulose nanofiber membrane as a skin auxiliary material.

1. The name of the product of this design: packaging box. 2. Purpose of this design product: used for packaging of skin dressings. 3. The design highlights of this design product lie in the shape and pattern of the product. 4. The picture or photo that best illustrates the design points: expanded state diagram. 5. The top view, bottom view, left view and right view have been expressed in the expanded state diagram, and the top view, bottom view, left view and right view are omitted.

The utility model provides a dressing fitting degree adjusting device, which belongs to the technical field of adjusting devices, and comprises a soft plate and an adjusting mechanism, the adjusting mechanism is arranged on the outer side of the soft plate, the adjusting mechanism comprises a battery module, a thin pump, a sensing control module, a connecting hose, a connecting block and an airtight patch, the battery module is fixedly arranged on the top of the soft plate, and the thin pump is arranged on the thin pump. And the thin pump is fixedly mounted at the top of the battery module. Through the arrangement of the adjusting mechanism, a proper amount of air is injected into the airtight patch through the thin pump to achieve the tight attaching effect, the pressure between the airtight patch and the skin surface can be adjusted, the comfortable effect is achieved, through the arrangement of the fixing mechanism, an inserting buckle and an inserting rod are fixed, and the fixing effect is good. The dressings in various forms can be fixed on the skin at various positions of the body, the fitting degree of the skin dressings can be greatly improved, the length can be adjusted by matching the limiting rod with the adjusting hole, and the dressing fixing device is suitable for different positions of the body.

The present invention discloses a method for preparing a skin-like dressing and a skin-like dressing, wherein the method part includes the following steps: S1 is a step for preparing a polyurethane layer by using an anionic aqueous polyurethane spinning solution and a cationic aqueous polyurethane spinning solution according to different specific gravities by using an electrostatic spinning process; S2 is a step for heat-treating the polyurethane layer by using a heat treatment process. S3 is a step for bonding an antibacterial layer to the polyurethane layer after heat treatment; S4 is a step for bonding a wound contact layer to the antibacterial layer. The method for preparing a skin-like dressing and the skin-like dressing disclosed in the present invention present a wrinkled appearance similar to that of skin, so that the polyurethane layer has high ductility, high elasticity and resilience, and can achieve dynamic bonding with the joint part.

A cover skin wrap (100), for use with cream (20) on skin (10) is provided. The object of the invention is achieved using a sealing layer on a base layer.

The present invention discloses a multifunctional lignin hydrogel for skin dressings and a preparation method thereof. The multifunctional lignin hydrogel is prepared by first dissolving curcumin powder and alkali lignin powder in a NaOH solution in a certain proportion, slowly adding the solution dropwise to an equal volume of silver ammonia solution, and reacting at room temperature for 30 to 60 minutes. A certain amount of nudiflorin, 2.7 g acrylamide, 0.3 g acrylic acid, 3 mg N,N-methylenebisacrylamide, and 45 mg ammonium persulfate are then dissolved in a dispersion of the nanoparticles described above, stirred to form a uniform solution, and allowed to stand at room temperature for 20 to 30 minutes to obtain a nudiflorin-loaded lignin-curcumin silver nanoparticle-poly(acrylamide-acrylic acid) hydrogel. The multifunctional lignin hydrogel prepared by the present invention has multiple functions, including adhesion, antibacterial, antioxidant, and hemostatic properties. It can be used to accelerate skin wound healing and has good application prospects in skin dressings.

The utility model discloses a skin dressing tailoring device convenient to position, which comprises a bottom plate, two tailoring knives are rotatably arranged at the position of the upper part of the bottom plate close to one side, a storage structure is arranged at the middle position of the upper part of the bottom plate, the storage structure comprises a storage cylinder, the storage cylinder is fixedly arranged at the middle position of the upper part of the bottom plate, and the storage cylinder is fixedly arranged on the bottom plate. A stand column is fixedly installed in the middle of the bottom side of the interior of the storage barrel, and an opening is formed in the position, corresponding to the cutter, of the barrel wall of the storage barrel. According to the skin dressing cutting device convenient to position, through the combined action of the containing cylinder, the stand column and the cylinder cover, when the skin dressing cutting device convenient to position is used, the cylinder cover is taken down, the stand column of the containing cylinder is sleeved with a medical gauze roll, then a connector of the cylinder cover is screwed into a connecting groove of the stand column, and the medical gauze roll is isolated from the external environment; compared with a traditional medical gauze roll storage mode, the medical gauze roll storage device is safer and more effective.

The present invention belongs to the technical field of skin dressings. The present invention provides a skin repair and whitening dressing based on a black-skinned spruce extract and a preparation method. The preparation method comprises the steps of: preparing a modified sodium hyaluronate solution by mixing citrine pectin with sodium hyaluronate; encapsulating a black-skinned spruce water extract dry powder, a black-skinned spruce ethanol aqueous solution extract dry powder and a citrine peel water extract in liposomes; and then placing the liposomes in a modified sodium hyaluronate solution to prepare a hydrogel colloid to obtain a dressing. The skin dressing obtained by the present invention can significantly inhibit tyrosinase and has a good scavenging rate for DPPH free radicals, and has a positive effect on skin whitening; at the same time, it also has excellent long-term antibacterial properties and can be used repeatedly for a long time; and it is also conducive to the repair and healing of burned skin.

The invention relates to a cell membrane and a corresponding medical repair material as well as a preparation method and application thereof. The extraction method of the mesenchymal stem cell membrane comprises the following steps: carrying out cracking, ultrasonication and centrifugation on mesenchymal stem cells to obtain the mesenchymal stem cell membrane. The mesenchymal stem cell membrane can promote wound healing and damage repair of skin barriers, and can be used for preparing skin dressings, medicines for treating wound healing and cosmetics. The obtained mesenchymal stem cell membrane can be used as an effective component for treating wounds and repairing skin, a new situation that the cell membrane is applied to wound healing treatment and skin repairing is developed, and a new choice is provided for skin dressing, wound healing drugs and cosmetics.

The invention discloses a skin puncture-free epidermal incision stitching instrument and a stitching method thereof.The skin puncture-free epidermal incision stitching instrument comprises skin dressing, a thread hanging support and a suture, the skin dressing is applied to the two sides of a skin incision and comprises a first plate and a second plate, and the first plate and the second plate are arranged in parallel; the first plate and the second plate are respectively provided with a plurality of thread hanging supports, the thread hanging supports on the first plate and the thread hanging supports on the second plate are arranged in a staggered mode to form an opposite staggered arrangement structure, the sewing threads are arranged to be sequentially clamped into the thread hanging supports, the sewing threads are in a Z-shaped trend on the skin auxiliary materials, and after the sewing threads are tensioned to close an incision, the skin auxiliary materials are cut off. And the redundant end part of the sewing thread is wound on the thread hanging bracket at the tail end. The external structure is adopted for clamping the thread, the tension of a sutured wound is borne, damage to skin tissue can be avoided, stress concentration is eliminated, scars are prevented from being generated in the healing process, and the production cost is low.

The present invention belongs to the field of human body care technology, and discloses an oligomeric agarose sol, a preparation method, and an application thereof. The oligomeric agarose sol provided by the present invention is in the form of an opaque semi-fluid colloid or a solidified colloid at room temperature, and the degree of polymerization n is 2 to 10,000. The oligomeric agarose sol with such a special form and a specific degree of polymerization enables the polymer to have excellent moisturizing ability and the ability to promote the healing of micro-wounds. It can be used as a moisturizing ingredient in cosmetics, and has an excellent moisturizing effect regardless of whether it is in a high humidity environment or a dry environment, and has a significant effect on improving the expression of filaggrin in human keratinocytes; in the field of medical dressings, it can be used as a skin dressing to promote the healing of micro-wounds. Therefore, the oligomeric agarose sol provided by the present invention has a high application value as a bioactive substance.