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Medical porous fiber membrane and preparation method thereof

A porous fiber and mixture technology, applied in the field of biomedical materials, can solve the problems of insufficient mechanical strength, cumbersome manufacturing process, and poor biocompatibility, and achieve the effect of promoting wound healing, short process flow, and good pore structure

Inactive Publication Date: 2019-06-14
KUNMING UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, the existing medical dressings generally have problems such as insufficient mechanical strength and poor biocompatibility, and the production process is cumbersome, and poor anti-infection properties hinder their further use.

Method used

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  • Medical porous fiber membrane and preparation method thereof
  • Medical porous fiber membrane and preparation method thereof
  • Medical porous fiber membrane and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] A medical porous fiber membrane is prepared by electrospinning with sodium hyaluronate, gelatin, konjac glucomannan and nano-hydroxyapatite as raw materials.

[0029] The preparation method of the medical porous fiber membrane in this embodiment, the specific steps are as follows:

[0030] (1) Under the condition of magnetic stirring, according to the solid-liquid ratio g:mL of gelatin and glacial acetic acid is 1:2, mix gelatin and glacial acetic acid until the gelatin is completely dissolved and no air bubbles can be observed in the liquid to obtain For mixture A, the magnetic stirring speed is 400r / min;

[0031] (2) Under the condition of magnetic stirring, according to the solid-liquid ratio g:mL of konjac glucomannan and mixture A is 1:200, add konjac glucomannan to mixture A in step (1) to obtain mixture B , the magnetic stirring speed is 400r / min;

[0032] (3) Under the condition of magnetic stirring, according to the solid-liquid ratio g:mL of sodium hyalurona...

Embodiment 2

[0040] A medical porous fiber membrane is prepared by electrospinning with sodium hyaluronate, gelatin, konjac glucomannan and nano-hydroxyapatite as raw materials.

[0041] The preparation method of the medical porous fiber membrane in this embodiment, the specific steps are as follows:

[0042] (1) Under the condition of magnetic stirring, according to the solid-liquid ratio g:mL of gelatin and glacial acetic acid is 1:20, mix gelatin and glacial acetic acid until the gelatin is completely dissolved and no air bubbles can be observed in the liquid to obtain For mixture A, the magnetic stirring speed is 500r / min;

[0043] (2) Under magnetic stirring conditions, according to the solid-to-liquid ratio g:mL of konjac glucomannan and mixture A ratio of 1:1000, konjac glucomannan was added to mixture A in step (1) to obtain mixture B , the magnetic stirring speed is 500r / min;

[0044] (3) Under magnetic stirring conditions, according to the solid-to-liquid ratio g:mL of sodium h...

Embodiment 3

[0052] A medical porous fiber membrane is prepared by electrospinning with sodium hyaluronate, gelatin, konjac glucomannan and nano-hydroxyapatite as raw materials.

[0053] The preparation method of the medical porous fiber membrane in this embodiment, the specific steps are as follows:

[0054] (1) Under the condition of magnetic stirring, according to the solid-liquid ratio g:mL of gelatin and glacial acetic acid is 1:10, mix gelatin and glacial acetic acid until the gelatin is completely dissolved and no air bubbles can be observed in the liquid to obtain For mixture A, the magnetic stirring speed is 450r / min;

[0055] (2) Under the condition of magnetic stirring, according to the solid-liquid ratio g:mL of konjac glucomannan and mixture A is 1:600, add konjac glucomannan to mixture A in step (1) to obtain mixture B , the magnetic stirring speed is 450r / min;

[0056] (3) Under the condition of magnetic stirring, according to the solid-liquid ratio g:mL of sodium hyaluron...

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Abstract

The invention discloses a medical porous fiber membrane and a preparation method thereof. According to the invention, gelatin, konjac glucomannan and sodium hyaluronate are used as main raw materials,glacial acetic acid is used as a solvent to increase the strength and toughness of the porous membrane by adding nano-hydroxyapatite, and the sodium hyaluronate / gelatin / konjac glucomannan / nano-hydroxyapatite porous fiber membrane can be prepared. The preparation process is short, the method is simple and convenient, and the prepared medical porous fiber membrane has good mechanical properties and good biocompatibility. The physically crosslinked porous fiber membrane material has great application potential in artificial skin, skin dressing, drug loading, cartilage repair, cancellous bone microdefect and the like.

Description

technical field [0001] The invention relates to a medical porous fiber membrane material and a preparation method thereof, belonging to the technical field of biomedical materials. Background technique [0002] The source of human skin is limited, and allogeneic skin transplantation will cause immune rejection, so people have been looking for and researching materials that can treat skin burns, and they have certain skin functions. People usually call such materials artificial skin materials. It was developed from early medical dressings used to treat skin burns. [0003] Due to the advantages of high porosity, large specific surface area, strong adsorption and filterability, medical fiber membranes are widely used in biomedical functional materials. They can be applied externally on the surface of organisms to promote wound healing, and can also be used for drug loading, cartilage repair, Cancellous bone microdefects, etc. The medical porous fiber membrane material is use...

Claims

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Application Information

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IPC IPC(8): A61L26/00A61L27/12A61L27/20A61L27/22A61L27/56A61L27/60
Inventor 冷崇燕竹泳俊陈庆华支燕汪虹刘金坤严继康颜廷亭陈希亮
Owner KUNMING UNIV OF SCI & TECH
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