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Non-toxic environment-friendly solvent type double-layer nanofiber skin dressing and preparation method thereof

A non-toxic, environmentally friendly, nanofiber technology, applied in medical science, non-woven fabrics, absorbent pads, etc., can solve problems such as organic solvent residues, achieve good comfort, avoid inflammatory reactions, and promote wound healing

Inactive Publication Date: 2020-02-11
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem to be solved by the present invention is: the technical problem of organic solvent residue in the existing nanofiber skin dressing

Method used

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  • Non-toxic environment-friendly solvent type double-layer nanofiber skin dressing and preparation method thereof
  • Non-toxic environment-friendly solvent type double-layer nanofiber skin dressing and preparation method thereof
  • Non-toxic environment-friendly solvent type double-layer nanofiber skin dressing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] A kind of preparation method of non-toxic and environment-friendly solvent-based gelatin-PVB / polydimethylsiloxane (PDMS) nanofiber double-layer skin dressing, the specific steps are:

[0030] Step 1: dissolving gelatin in deionized water, hydrating at 30°C-35°C for 20-40min, then raising the temperature to 50-60°C to dissolve completely, and preparing a gelatin solution with a mass fraction of 10-20%. adding tannic acid with a mass ratio of 1-10% to the gelatin solution into the gelatin solution, stirring in a water bath for 10-20 minutes to mix evenly, adding 0.1-2wt% anti-inflammatory drug curcumin solution with a mass ratio to the gelatin, and stirring evenly;

[0031] Dissolve PVB with a mass concentration of 8-15% in absolute ethanol, stir at room temperature to dissolve completely; dissolve PDMS with a mass ratio of 10-60% to PVB in the above solution, and continue stirring at room temperature;

[0032] The second step: using the nanofibers obtained in the second ...

Embodiment 2

[0038] A method for preparing a non-toxic and environmentally friendly solvent-based gelatin-PU / fluorine-containing PU nanofiber double-layer skin dressing, the specific steps are:

[0039] Step 1: dissolving gelatin in deionized water, hydrating at 30°C-35°C for 20-40min, then raising the temperature to 50-60°C to dissolve completely, and preparing a gelatin solution with a mass concentration of 10-20%. adding tannic acid with a mass ratio of 1-10% to the gelatin solution into the gelatin solution, stirring in a water bath for 10-20 minutes to mix evenly, adding 0.1-2wt% anti-inflammatory drug curcumin solution with a mass ratio to the gelatin, and stirring evenly;

[0040]Dissolve water-soluble PU with a mass concentration of 3-10% in absolute ethanol, stir at room temperature to dissolve completely; dissolve fluorinated PU with a mass ratio of 10-60% to PU in the above solution, and continue stirring at room temperature;

[0041] The second step: put the gelatin solution pr...

Embodiment 3

[0047] A method for preparing a non-toxic and environmentally friendly solvent-based collagen-PVB / PDMS nanofiber double-layer skin dressing, the specific steps are:

[0048] Step 1: Dissolve collagen in acetic acid solution with a volume concentration of 50-90%, and dissolve completely to prepare a collagen solution with a mass concentration of 5-15%, add EDC / NHS solution with a mass concentration of 10-20%, and stir evenly. Add 0.1-2wt% anti-inflammatory drug meloxicam solution with the mass ratio of collagen, and stir evenly;

[0049] Dissolve PVB with a mass concentration of 8-15% in absolute ethanol, stir at room temperature to dissolve completely; dissolve PDMS with a mass ratio of 10-60% to PVB in the above solution, and continue stirring at room temperature;

[0050] The second step: put the collagen solution prepared in the first step into a syringe, and use an electrospinning device for spinning. The spinning voltage is 10-20kV, the receiving distance is 10-15cm, the...

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Abstract

The invention discloses a non-toxic environment-friendly solvent type double-layer nanofiber skin dressing and a preparation method thereof. The non-toxic environment-friendly solvent type double-layer nanofiber skin dressing comprises a drug-loaded hydrophilic repair natural polymer fiber layer and a waterproof and breathable synthetic polymer fiber layer, and is prepared by adopting a non-toxicenvironment-friendly solvent system through an electrostatic spinning technology layer by layer. The preparation method comprises the steps that a natural polymer and a drug are dissolved in a non-toxic environment-friendly solvent, and a cross-linking agent is added; a synthetic polymer is dissolved in the non-toxic environment-friendly solvent, and a water repellent agent is added; and a naturalpolymer solution and a synthetic polymer solution are placed in an injection syringe, and an electrostatic spinning device is adopted for spinning to prepare a double-layer fiber membrane. The double-layer nanofiber skin dressing prepared through the preparation method does not contain a toxic solvent, and does not generating toxic and side effects on open wounds when serving as the dressing; andthe double-layer nanofiber skin dressing has waterproof and breathable performance, is good in cytocompatibility, can promote wound healing of rats with skin damages, and has the huge application prospects in the field of skin dressings.

Description

technical field [0001] The invention relates to a non-toxic and environment-friendly solvent-type nanofiber double-layer skin dressing and a preparation method thereof, belonging to the field of biomedical materials. Background technique [0002] According to statistics, tens of millions of people in my country have skin trauma caused by accidents and operations every year. At present, autologous skin transplantation is still the most effective clinical treatment for skin defects, but its application is severely limited due to limited sources and secondary injuries. Therefore, as an important medical product for wound care, skin dressings have the functions of stopping bleeding, preventing infection and promoting wound healing, and have been widely used in wound care. However, my country is relatively weak in the research and development of high-end dressings, mainly relying on imports. The current dressing products mainly play a role of physical isolation, and their abili...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/32A61L15/26A61L15/28A61L15/24A61L15/44D04H1/728
CPCA61L15/24A61L15/26A61L15/28A61L15/32A61L15/44D04H1/728C08L83/04C08L5/08C08L29/04
Inventor 李晓然郭玉霞周文丁彬俞建勇
Owner DONGHUA UNIV
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