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Conductive polypyrrole/traditional Chinese medicine composite hydrogel, preparation method and application thereof

A composite hydrogel and conductive polymer technology, applied in the field of medical biomaterials, can solve the problems of not promoting cell proliferation, adhesion, wound healing, limiting the application of hydrogel dressings, and complicated manufacturing processes, so as to promote cell adhesion and proliferation, prolong drug Action time, effect of promoting cell proliferation

Active Publication Date: 2021-02-12
SOUTH CHINA UNIV OF TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Some studies have used metal nanoparticles such as silver and copper to modify hydrogels to obtain antibacterial properties, but the cost of raw materials is high; some researchers have obtained water with good antibacterial rates based on three raw materials: amino acids, dithiobipyridine and aluminum salts. Gel dressing, but the production process is relatively complicated, and the function is single
In addition, none of these dressings can promote cell proliferation and adhesion to promote wound healing, which limits the application of hydrogel dressings.

Method used

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  • Conductive polypyrrole/traditional Chinese medicine composite hydrogel, preparation method and application thereof
  • Conductive polypyrrole/traditional Chinese medicine composite hydrogel, preparation method and application thereof
  • Conductive polypyrrole/traditional Chinese medicine composite hydrogel, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] A preparation method of conductive polypyrrole / Chinese medicine composite hydrogel, comprising the following steps:

[0036] (1) Take ice cubes and place them in a foam box to maintain a low temperature environment.

[0037] (2) Preparation of solution A: Pipette 85 μL of pyrrole monomer into 1 ml of isopropanol, stir magnetically to make it evenly mixed; then weigh 0.03 g of traditional Chinese medicine (baicalin, berberine, curcumin and ginseng saponin) powder is dissolved in the above solution, magnetically stirred at room temperature, put into the above foam box after the dissolution is complete, and stored at low temperature for use.

[0038] (3) Preparation of solution B: Weigh 0.274g of ammonium persulfate powder and add it to 2ml of deionized water, stir it magnetically at room temperature, put it into the above-mentioned foam box after it is completely dissolved, and store it at low temperature for use.

[0039] (4) Use a pipette gun to take 70 μL of solution ...

Embodiment 2

[0042] Antibacterial effect test of conductive polypyrrole / traditional Chinese medicine composite hydrogel. The antibacterial effect of this conductive polypyrrole / Chinese medicine composite hydrogel was characterized by the antibacterial ring. Take 100 μL E. coli suspension (10 6 CFU / ml) evenly spread on the LB agar plate, let it stand for a period of time, place the conductive polypyrrole composite hydrogel (1 cm in diameter) doped with baicalin obtained in Example 1 in the middle of the agar plate, and incubate at 37°C After 24 hours of cultivation in the box, the observation results were taken out. The obtained antibacterial results were as Figure 4 , forming an obvious antibacterial zone around the hydrogel, which shows that the conductive polypyrrole / Chinese medicine composite hydrogel has a significant antibacterial effect.

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Abstract

The invention discloses conductive polypyrrole / traditional Chinese medicine composite hydrogel, a preparation method and application thereof. According to the method, polypyrrole hydrogel is used as amain body structure, and traditional Chinese medicine molecules are used as a doping agent to be doped into a hydrogel network, so that the antibacterial hemostatic skin dressing with the wound healing promoting function is prepared. According to the invention, the preparation method is simple, the cost is low, and the reaction conditions are easy to control; and the obtained composite hydrogel is good in biocompatibility, has a certain antibacterial effect and a certain effect of promoting cell proliferation and adhesion, and is a very good skin dressing material.

Description

technical field [0001] The invention belongs to the technical field of medical biological materials, and in particular relates to a conductive polypyrrole / traditional Chinese medicine composite hydrogel and its preparation method and application. Background technique [0002] The skin is a barrier of the human body, and its function is to protect the human body, discharge waste, regulate body temperature, etc. The skin is in direct contact with the external environment and is vulnerable to external damage (such as extensive burns, wounds, and surgical wounds), resulting in skin ulcers, ulcers, bleeding, and allergic reactions. Usually these wounds take a long time to heal, and the function of the dressing is to temporarily isolate the wound from the external environment, provide a relatively independent environment for skin repair, avoid secondary stimulation, and promote wound repair. [0003] Traditional dressings mostly use medical gauze, which is cheap and easy to obtai...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K47/34A61K31/7048A61K31/4375A61K31/12A61K31/704A61P31/02A61P17/02A61P7/04C08J3/075C08L79/04C08L99/00C08G73/06
CPCA61K9/06A61K9/0014A61K47/34A61K31/7048A61K31/4375A61K31/12A61K31/704A61P31/02A61P17/02A61P7/04C08J3/075C08G73/0611C08J2379/04C08J2399/00
Inventor 宁成云王珍高黄怡萱李潇陈宇航于鹏李玮周蕾李扬帆杨虹
Owner SOUTH CHINA UNIV OF TECH
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