This invention relates to compounds, compositions, and methods useful for modulating NF-kappa B,
REL-A,
REL-B,
REL, NKkappaB1, or NFkappaB2
gene expression using short interfering
nucleic acid (siNA) molecules. This invention also relates to compounds, compositions, and methods useful for modulating the expression and activity of other genes involved in pathways of NF-kappa B, REL-A, REL-B, REL, NKkappaB1, or NFkappaB2
gene expression and / or activity by
RNA interference (RNAi) using small
nucleic acid molecules. In particular, the instant invention features small
nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering
RNA (siRNA), double-stranded
RNA (dsRNA), micro-RNA (mRNA), and short hairpin RNA (shRNA) molecules and methods used to modulate the expression of NF-kappa B, REL-A, REL-B, REL, NKkappaB1, or NFkappaB2 genes, such as NF-kappa B and / or REL-A.