Traditional Chinese medicine ingredient modified multifunctional bacterial cellulose-based skin dressing and preparation method thereof

A bacterial cellulose, multi-functional technology, applied in bacterial cellulose-based skin dressing, multi-functional bacterial cellulose-based skin dressing and its preparation field, to promote wound healing, reproducible, safe, non-toxic, and reproducible Effect

Active Publication Date: 2021-12-24
EAST CHINA JIAOTONG UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, traditional Chinese medicine organic acids, especially protocatechuic acid, have not been publicly reported on the external use of diabetic foot ulcers.

Method used

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  • Traditional Chinese medicine ingredient modified multifunctional bacterial cellulose-based skin dressing and preparation method thereof
  • Traditional Chinese medicine ingredient modified multifunctional bacterial cellulose-based skin dressing and preparation method thereof
  • Traditional Chinese medicine ingredient modified multifunctional bacterial cellulose-based skin dressing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] Example 1 Preparation and Characterization of Drug Functionalized Bacterial Cellulose-Based Skin Dressing I

[0049] The chitosan quaternary ammonium salt was complexed with bacterial cellulose by growing chitosan quaternary ammonium salt in situ in bacterial cellulose. Add chitosan quaternary ammonium salt to the bacterial cellulose medium so that its final concentration is 3 mg / ml, inoculate 10% bacterial cellulose strains into the medium, mix well and configure it as seed liquid. Take a clean 24-well plate, inoculate 1 ml of seed solution in each well, and culture at a constant temperature of 30° C. so that the thickness of the chitosan quaternary ammonium salt / bacterial cellulose composite film is 10 mm. Purify the obtained chitosan quaternary ammonium salt / bacterial cellulose composite membrane: place the obtained chitosan quaternary ammonium salt / bacterial cellulose composite membrane in a 0.5mol / L NaOH solution for ultrasonic treatment for 2 hours; In water, son...

Embodiment 2

[0051] Example 2 Preparation and Characterization of Drug Functionalized Bacterial Cellulose-Based Skin Dressing II

[0052] The chitosan quaternary ammonium salt was complexed with bacterial cellulose by growing chitosan quaternary ammonium salt in situ in bacterial cellulose. Add chitosan quaternary ammonium salt to the bacterial cellulose medium so that its final concentration is 3 mg / ml, inoculate an appropriate amount of bacterial cellulose strains into the medium, and fully mix to prepare a seed solution. Take a clean 24-well plate, inoculate 1 ml of seed solution in each well, and culture at a constant temperature of 30° C. so that the thickness of the chitosan quaternary ammonium salt / bacterial cellulose composite film is 10 mm. Purify the obtained chitosan quaternary ammonium salt / bacterial cellulose composite membrane: place the obtained chitosan quaternary ammonium salt / bacterial cellulose composite membrane in a 0.5mol / L NaOH solution for ultrasonic treatment for 2...

Embodiment 3

[0054] Example 3 Preparation and Characterization of Drug Functionalized Bacterial Cellulose-Based Skin Dressing III

[0055] The chitosan quaternary ammonium salt was complexed with bacterial cellulose by growing chitosan quaternary ammonium salt in situ in bacterial cellulose. Add chitosan quaternary ammonium salt to the bacterial cellulose medium so that its final concentration is 5 mg / ml, inoculate an appropriate amount of bacterial cellulose strains into the medium, and fully mix to prepare a seed solution. Take a clean 24-well plate, inoculate 1 ml of seed solution in each well, and culture at a constant temperature of 30° C. so that the thickness of the chitosan quaternary ammonium salt / bacterial cellulose composite film is 10 mm. Purify the obtained chitosan quaternary ammonium salt / bacterial cellulose composite membrane: place the obtained chitosan quaternary ammonium salt / bacterial cellulose composite membrane in a 0.5mol / L NaOH solution for ultrasonic treatment for ...

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Abstract

The invention provides a traditional Chinese medicine ingredient modified multifunctional bacterial cellulose-based skin dressing and a preparation method thereof. The traditional Chinese medicine ingredient modified multifunctional bacterial cellulose-based skin dressing comprises a chitosan quaternary ammonium salt/bacterial cellulose composite membrane and traditional Chinese medicine organic acid grafted on the composite membrane. According to the invention, function modification is performed on bacterial cellulose by utilizing active ingredients of natural traditional Chinese medicines, namely traditional Chinese medicine organic acid and chitosan quaternary ammonium salt, so that the original bacterial cellulose base has the functions of resisting bacteria, resisting inflammation, resisting oxidation, promoting wound healing and the like.

Description

technical field [0001] The invention relates to a multifunctional bacterial cellulose-based skin dressing modified by traditional Chinese medicine components and a preparation method thereof. Specifically, it involves a kind of functional drug raw material that uses traditional Chinese medicine organic acid and chitosan quaternary ammonium salt, compounded on bacterial cellulose according to a certain concentration ratio, and has the four functions of antibacterial, anti-inflammatory, anti-oxidation, and promotion of wound healing. A drug-function bacterial cellulose-based skin dressing. It belongs to the field of biomedical materials. Background technique [0002] Compared with common skin ulcers, diabetic foot ulcers are more difficult to heal, because in addition to being extremely susceptible to infection, vascular disease and neuropathy caused by diabetes constitute internal factors that affect ulcer healing. Therefore, the development of multifunctional dressings wit...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61L15/44A61L15/46A61L15/20
CPCA61L15/28A61L15/44A61L15/46A61L15/20A61L2300/21A61L2300/204A61L2300/404A61L2300/41A61L2300/412A61L2300/45C08L5/08C08L1/02
Inventor 敖海勇周宸杨志飞万怡灶
Owner EAST CHINA JIAOTONG UNIVERSITY
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