Method for manufacturing fungus pharmaceutical composition

A technology of a pharmaceutical composition and a manufacturing method, which is applied in the directions of pharmaceutical formulations, pharmaceutical sciences, and medical preparations with inactive ingredients, etc., can solve the problems of exudate re-infiltration, insignificant moisturizing power of tissue fluid and skin wounds, and hardening.

CN107432957AInactive Publication Date: 2017-12-05TAIWAN INDIGENA BOTANICA CO LTD +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Publication Date
2017-12-05
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides a method for manufacturing a fungus pharmaceutical composition. The method comprises steps of knocking, kneading, extension, organic solvent extraction, high temperature alkali treatment, filtering and decolouring. The method is used for extracting poly(glucosamine) cellulose from fungus cell walls. The poly(glucosamine) cellulose is different poly(glucosamine) cellulose made from a China Taiwan patent, the patent number of which is 442496, and having defects of ultralow yield, rougher cellulose, and yellowy color. The poly(glucosamine) cellulose made through the method relatively shows the advantage of high yield, fine cellulose, and white color. The prepared poly(glucosamine) cellulose can be made into an excipient. Furthermore, it is proved through experiments that the poly(glucosamine) cellulose has excellent adsorption power and moisture maintenance of a tissue fluid, and is quite suitable for being used as a skin dressing, artificial skin, or a mask.
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Description

technical field

[0001] The invention relates to the technical field of medical compositions, in particular to a method for preparing a fungal medicinal composition for extracting a complex of chitin and polysaccharide from fungal cell walls. Background technique

[0002] The skin not only has the function of regulating body temperature and water balance in the body, but also is the first line of defense for the human body to defend against the invasion of external pathogens. Therefore, when the skin is injured in a large area, it may cause an imbalance of thermoregulatory function, and severe cases may cause death. Generally speaking, after the skin wound is treated with drugs, the wound will still be in contact with clothing or the outside world, and the wound will deteriorate due to contamination with external dust or bacteria. Therefore, in order to prevent the wound from being contaminated with external dust or bacteria, medical personnel usually cover a skin dressing (...

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Embodiment Construction

[0065] In order to describe more clearly the manufacturing method of a fungal pharmaceutical composition proposed by the present invention, the preferred embodiments of the present invention will be described in detail below with reference to the drawings.

[0066] Polysaccharides are the main components of fungal cell walls. In the fungal cell wall, polysaccharides and chitin are stacked alternately to form an elastic shell that gives the fungal cell its shape. The fungal cell wall can not only prevent the invasion of destructive macromolecules (such as decomposing enzymes, lytic enzymes), but also is more permeable, so that fungal cells can absorb water and small molecule nutrients through it. As known to those familiar with the development of biomedical materials, chitin (or chitosan) has the advantages of good biocompatibility, no biotoxicity, low price, easy modification, and good mechanical strength. Chitin (or chitosan) is usually processed into films, beads, fibers, o...