A kind of skin dressing and preparation method thereof

A skin-to-skin contact technology, applied in medical science, absorbent pads, bandages, etc., can solve problems such as the speed of drug release not meeting the requirements, and achieve the effects of accelerated release, directional induction repair, and convenient use.

Active Publication Date: 2018-09-21
致成医疗科技(湖北)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the speed of its drug release is still not up to the requirement

Method used

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  • A kind of skin dressing and preparation method thereof
  • A kind of skin dressing and preparation method thereof
  • A kind of skin dressing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0049] The preparation method of skin dressing includes doping method and suction filtration method, wherein the doping method includes the following steps:

[0050] (1) Soak a bacterial cellulose film with a thickness of 3 mm to 14 mm in a solution or suspension of a conductive material, so that the conductive material penetrates into the surface of the bacterial cellulose film at 1 mm to 3 mm, and the surface is conductive The content of the material is 5mg / cm 2 ~50mg / cm 2 ;

[0051] (2) Cut the bacterial cellulose film in a direction parallel to the surface, and control the thickness of the cut to obtain a composite hydrogel film of 2mm-7mm;

[0052] (3) Soak the composite hydrogel film in a drug solution with a concentration of 2μg / ml-20μg / ml for 12h~48h to make the surface of the composite hydrogel film adsorb 2μg / cm 2 ~20μg / cm 2 To obtain the skin dressing; the drug is one or more of blood coagulation drugs, anti-allergic drugs, analgesics, and cell growth factors.

[0053] Wher...

Embodiment 1

[0065] Use Acetobacter gluconobacter ATCC53582, inoculate it in S-H medium (medium composition: 1L of water containing 20 grams of glucose, 5 grams of yeast powder, 5 grams of peptone, 1.5 grams of citric acid, 2.7 grams of disodium hydrogen phosphate). After standing and culturing at 26°C for 15 days, a bacterial cellulose hydrogel hydrogel with a thickness of about 10mm-12mm is obtained. Soak the bacterial cellulose hydrogel in distilled water for two days, then boil it in 1wt% sodium hydroxide solution for 30 minutes, take it out and wash it with distilled water until it is neutral to obtain a pure bacterial cellulose hydrogel at 4°C Save it for later use.

[0066] (1) The bacterial cellulose hydrogel is soaked in a 20% ammonium persulfate solution and allowed to stand for 24 hours. Take it out, rinse the surface with distilled water three times, then soak the bacterial cellulose hydrogel in a 1:10 volume solution of pyrrole monomer and ethanol, and let it stand for 0.5 hours...

Embodiment 2

[0071] Example 1 was repeated with the same steps as described, except that the aniline monomer was substituted for the pyrrole monomer.

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Abstract

The invention discloses a skin dressing and a preparation method of the skin dressing. The skin dressing takes bacterial cellulose as a base and has a skin contact surface and a conductive surface, wherein the electric conductivity of the skin contact surface is smaller than 10<-5>S / cm and the skin contact surface contains 2Mug / cm<2> to 20Mug / cm<2> of drugs; the conductive surface contains 5mg / cm<2> to 50mg / cm<2> of a conductive material, and the conductive material is one or more of a conductive macromolecular material and a conductive nano material; the skin contact surface is used for being in direct contact with a skin so as to heal a wound of the skin; the conductive surface is used for loading voltage so as to control the releasing speed of the drugs on the skin contact surface, and is also used for simulating a biological endogenous electrical field and indirectly accelerating the healing of the wound. According to the skin dressing disclosed by the invention, the conductive surface is in tight combination with the skin contact surface, so that the endogenous electrical field of the wound of the skin can be simulated very well and the skin dressing is more convenient to use.

Description

Technical field [0001] The invention belongs to the field of biomedical materials, and more specifically, relates to a skin dressing and a preparation method thereof. Background technique [0002] Skin dressings can be used to protect and cover wounds after trauma. Modern skin dressings can not only resist mechanical irritation, resist pollution and chemical irritation, prevent secondary infection, prevent dryness and body fluid loss, etc., but also debride wounds, simulate biological endogenous electric fields to induce skin repair, and actively affect the wound healing process , Create a microenvironment that promotes wound healing. [0003] For example, patent document CN 103205863A discloses a preparation method of bacterial cellulose sustained-release dressing. A polymer nanofiber with drug slow-release function is obtained, and the original three-dimensional nano network structure of bacterial cellulose is maintained. However, the rate of drug release is still not up to th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/28A61L15/44A61L15/42
CPCA61L15/28A61L15/42A61L15/44A61L2300/402A61L2300/404A61L2300/414A61L2300/418A61L2300/426C08L1/02
Inventor 杨光石志军蔡欣宇廖雅文周学思刘佳彤张海祥
Owner 致成医疗科技(湖北)有限公司
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