Three-dimensional printing and negative-pressure flushing combining integrated skin dressing and preparation method thereof

Abstract

The invention discloses a three-dimensional printing and negative-pressure flushing combining integrated skin dressing and a preparation method thereof. The three-dimensional printing and negative-pressure flushing combining integrated skin dressing comprises a biological semitransparent film, a medical sponge, a three-dimensional screen cloth layer and a biological scaffold layer which are arranged from outside to inside, wherein the biological scaffold layer is made from a bio-active glass / chitosan / silk fibroin composite scaffold material; and the bio-active glass / chitosan / silk fibroin composite scaffold material is prepared from the following raw materials: nano-scale bio-active glass NBG, a silk fibroin concentrated water solution and water-soluble chitosan that a degree of deacetylation DAC is greater than or equal to 85%. The three-dimensional printing and negative-pressure flushing combining integrated skin dressing provided by the invention is cheap in raw materials, simple inpreparation process, capable of easily regulating and controlling structural performances and a degradation rate, easy for standardization of quality and conducive to implementation of large-scale production; the skin dressing can effectively replace partial skin flaps, so as to complete repair of a full-thickness skin defect wound surface with high quality.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to an integrated skin dressing combined with three-dimensional printing and negative pressure washing and a preparation method thereof. Background technique [0002] The repair of the dermis is the key to the success of skin repair. The development of new composite dermis substitutes with more sources and meeting the actual clinical needs is an important problem that the medical and biomedical materials science circles have been exploring and trying to solve for many years. Using material bionics and skin tissue engineering related technologies to develop new bioactive skin wound repair products to help patients repair defective or difficult-to-heal skin wound tissue is of great significance for alleviating or relieving patients' pain, reducing medical burden, and improving quality of life. It also has broad market prospects. [0003] Synthetic polymer (inorganic) materials and natural p...

AI Technical Summary

Problems solved by technology

[0009] At present, the composite scaffold materials we are familiar with lack bioactive components such as pro-vascularization factors, and generally have the characteristics of poor vascularization and unsatisfactory transplantation effect; while they contain basic fibroblast growth factor (bFGF) and vascular endothelial cells The active scaffold material of growth factor (VEGF) has high cost, short half-life and safety problems, so it is difficult to be widely used clinically.

And the existing skin dressing also has the following disadvantages: the dressing has poor air permeability, which easily causes wound infection to worsen, requires frequent dressing changes, and the wound repair effect of the dressing is relatively poor.

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