Improvements relating to skin dressings

A skin and nitrosothiol technology, applied in skin diseases, drug combinations, bandages, etc., can solve problems such as insufficient vasodilation, oxidative stress limitation, etc.

Inactive Publication Date: 2008-03-05
INSENSE LIMITED
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0050] Insufficient vasodilation and excessive oxidative stress (i.e. high production of superoxide) also limit the beneficial role of NO in venous ulcer healing

Method used

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  • Improvements relating to skin dressings
  • Improvements relating to skin dressings
  • Improvements relating to skin dressings

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0174] Example 1: Effect of pH on GSNO Production in Aqueous Systems Containing L-Glutathione and Potassium Nitrite The role of growth / decomposition rate

[0175] The effects of GSNO containing potassium nitrite ( 5 mM) and L-glutathione (5 mM) in solution and the subsequent rate of decomposition. The results are shown in Figure 1. No production of GSNO was observed at pH 7. The initial production of GSNO was slower at pH 5 compared to pH 3. Compared with pH 3, the stability of GSNO produced at pH 5 is slightly higher.

Embodiment 2

[0176] Example 2: Generation of S-nitrosoglutathione in (unbuffered) activated hydrogel dressings

[0177] Concentration profiles of GSNO in activated dressings were measured in the absence of an additional source of protons. The first layer of the dressing consisted of a polyAMPS hydrogel containing potassium nitrite (30 mM). The second layer consisted of dry PVA (5%) containing L-glutathione (30 mM). No additional proton source was introduced into the dressing. The layers were brought together to activate the dressing and the results are shown in FIG. 2 . The concentration of GSNO generated in the dressing reached a maximum after about 2 hours. Subsequently, its concentration decreased slowly and steadily due to the slow decomposition of GSNO. GSNO was still measurable in the dressing 48 hours after activation.

Embodiment 3

[0178] Example 3: S-nitrosoglutathione from activated hydrogel dressings (without introducing additional protons source) to the blank hydrogel release

[0179] The first layer of the dressing consisted of a polyAMPS hydrogel containing potassium nitrite (30 mM). The second layer consisted of dry PVA (5%) containing L-glutathione (30 mM). No additional proton source was introduced into the dressing. Bringing the first and second layers together activates the dressing. Activated dressings were placed on blank hydrogel sheets (30% polyAMPS). The generation of GSNO inside the dressing and its gradual release into the blank hydrogel were measured and the results are shown in Figure 3.

[0180] The concentration of GSNO in the activated dressing reached a maximum at about 2 hours after the dressing was activated. Subsequently, its concentration decreased slowly and steadily due to the slow decomposition of GSNO. A slow stepwise release of GSNO from the activated dressing in...

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Abstract

A skin dressing is adapted, on activation, to release one or more S-nitrosothiols, preferably S-nitroso-L-glutathione. S-nitrosothiols decompose spontaneously to produce nitric oxide, which has beneficial effects on tissues, particularly in wound healing.

Description

technical field [0001] The present invention relates to skin dressings applied to parts of the human or animal body for the treatment of the skin (therapeutic or cosmetic use), and in particular (but not exclusively) to wound dressings for the treatment of damaged skin, especially skin lesions which Any disruption of the skin surface, whether caused by injury or disease, including skin ulcers, burns, cuts, punctures, contusions, blunt trauma, acne lesions, boils. The term "dermal dressing" includes dressings, such as patches, ointments, bandages, gauze, etc., used in conjunction with the transdermal delivery of agents. The term also includes materials in amorphous or liquid form. The term includes dressings that are generally applied to the surface of the body, including internal and external tissues, especially the skin including the scalp. The present invention is based on the beneficial properties of nitric oxide (NO). Background technique [0002] Physical and Chemic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/44A61L26/00
CPCA61L15/44A61L2300/254A61L2300/114A61L26/0066A61P17/00A61P17/02A61L26/008
Inventor 简·杰泽克林恩·帕特里夏·沃森
Owner INSENSE LIMITED
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