12 results about "S-Nitrosothiols" patented technology

Systems and methods are provided for non-invasive measurement of endogenous S-nitrosothiols and related measurements thereof. One or more sensors non-invasively measures a set of one or more biometric parameters within a region of interest of a subject to provide a time series of measurements for each of the set of biometric parameters. A medium stores machine-readable instructions that are executable by an associated processor to perform processing comprising receiving the time series of measurements of the biometric parameter, generating, using a predictive model, a value representing an endogenous S-nitrosothiol content of tissue within the region of interest from the time series of measurements of the biometric parameter, and providing, by a user interface, the value representing the endogenous S-nitrosothiol content of tissue within the region of interest to a user.

A method includes mixing a liquid carrier and a powder formulation including an S-nitrosothiol (RSNO) powder to form a nitric oxide generating solution; and within a predetermined time of mixing, introducing the nitric oxide generating solution into an inflatable and nitric oxide permeable balloon of a urinary catheter that is inserted in a patient.

The invention provides a nitrite quantitative detection method based on surface enhanced Raman spectroscopy, relates to the technical field of surface enhanced Raman spectroscopy, and constructs a self-correcting SERS substrate through a three-phase liquid-liquid interface co-assembly technology. In the experiment process, a sample to be detected is mixed with a thiobarbituric acid solution, the mixture is adjusted to be acidic, NO2 <-> and thiobarbituric acid are subjected to an S-nitrosation reaction, and S-nitroso mercaptan is generated. And then, immersing the self-correcting SERS substrate into a reaction solution, so that the substrate adsorbs the generated S-nitroso mercaptan, and further, a Raman signal is enhanced. After soaking is completed, the substrate is taken out and dried, finally, a Raman signal is collected through a Raman spectrometer, and the concentration of NO2 <-> is accurately analyzed through the change of the signal intensity. According to the technical scheme, rapid and high-sensitivity detection of NO2 <-> is achieved, good selectivity and anti-interference capacity are achieved, and the method is widely suitable for detection requirements of multiple fields such as environment monitoring and food safety.

Compositions and methods are presented for nitric oxide precursors that release nitric oxide upon decomposition. The nitric oxide precursors include the reaction products of thiol-containing alcohols, silanes, and nitrosated compounds, allowing for technically simple (e.g., solventless, one-pot synthesis) and flexible synthesis of nitric oxide precursors and mixtures thereof, and allowing for control of the nitric oxide release rate (e.g., via the use of primary, secondary, and / or tertiary nitrosothiols, alone or in combination with additives).

Radiosensitizer prodrugs and formulations and methods of use thereof are provided. Typically, the radiosensitizer prodrug is an analog of a radiosensitizer parent compound having one or more S-nitrosothiol moieties. Typically, the S—N bond of the S-nitrosothiol moiety can be cleaved by radiation during radiotherapy, releasing the parent compound and nitric oxide. One or preferably both the parent compound and the nitric oxide can contribute to death of tumor cells exposed to radiotherapy. Nanoparticle formulations for delivery of the prodrug, and methods of using them in combination with radiotherapy to treat tumors and cancer are also provided.

Compositions and methods for water-based production of polymers with nitrosothiol are provided. In a preferred aspect, the two-component polymer system maintains physical separation of thiol compounds and nitrite compounds. The two-component system can then be applied to a surface in a water-based process and heated to evaporate water and melt the polymer, allowing the formation of the nitrosothiol that will release nitric oxide from the nitrosothiol upon cooling of the polymer.

The invention relates to the technical field of biomedical polymer materials, and discloses a preparation method of an artificial pulmonary membrane material. The method comprises the following steps: mixing vinyl-containing polydimethylsiloxane, a sulfydryl-containing silane monomer, a sulfonate group-containing functional monomer, a rhodamine lactam structure-containing early warning functional monomer and a hydrogen-containing silicone oil cross-linking agent to prepare a precursor solution; coating a microporous support membrane with the precursor solution, heating and curing, so that each functional monomer is integrated into a polymer network through covalent bonds; and finally, carrying out an in-situ nitrosation reaction, and converting the immobilized sulfydryl into S-nitroso mercaptan. According to the invention, functional units are stably immobilized in the form of covalent bonds, so that the problems that the existing physical coating is easy to fall off and the anticoagulant performance is quickly attenuated are solved. The prepared material can synergistically release nitric oxide and realize lasting anticoagulation by utilizing fixed negative charges, and the integrated fluorescent unit can also respond to local pH drop in the initial stage of thrombus, so that the material is endowed with in-situ real-time early warning capability for failure risk.

Compositions and methods are presented for a nitric oxide precursor that decomposes to thereby release nitric oxide. The nitric oxide precursor includes a reaction product of a thiol-containing alcohol, a silane, and a nitrosating compound that allows for technically simple (e.g., solventless 1-pot synthesis) and flexible synthesis of nitric oxide precursors and mixtures thereof that allow for controlled release rate of nitric oxide (e.g., via use of primary, secondary, and / or tertiary nitrosothiols, alone or in combination with additives).

Radiosensitizer prodrugs and formulations and methods of use thereof are provided. Typically, the radiosensitizer prodrug is an analog of a radiosensitizer parent compound having one or more S-nitrosothiol moieties. Typically, the S—N bond of the S-nitrosothiol moiety can be cleaved by radiation during radiotherapy, releasing the parent compound and nitric oxide. One or preferably both the parent compound and the nitric oxide can contribute to death of tumor cells exposed to radiotherapy. Nanoparticle formulations for delivery of the prodrug, and methods of using them in combination with radiotherapy to treat tumors and cancer are also provided.

A composition and a kit comprising a nitrite source admixed with a gelling agent for nitric oxide production. Also disclosed is a method for generating nitric oxide, which finds applications in the treatment of various diseases.

Compositions and methods are provided in which an extruded article, or a portion thereof, includes a plurality of nitrosothiol groups derived from extruding a homogeneous mixture of a thiol-containing component and a nitrite-containing component through a mold. The nitrosothiol groups present in the extruded article can decompose to form nitric oxide to sterilize articles stored within the extruded article.

The invention provides a nitrosothiol modified vascular anastomosis device which comprises a tubular structure, a plurality of wire grooves are formed in the outer surface of the tubular structure, a nitric oxide release coating is loaded on the outer surface of the tubular structure, and the nitric oxide release coating is coated on the outer surface of the tubular structure. The nitric oxide release coating is a polydopamine coating, and S-nitroso-N-acetyl-DL-penicillamine is chemically grafted on the surface of the polydopamine coating. The invention further provides a preparation method of the nitrosothiol modified vascular anastomosis device. The preparation method comprises a design method of the vascular anastomosis device and a preparation method of the nitric oxide release coating. The nitrosothiol modified anastomosis device has the advantages that anastomosis is rapid, anastomosis strength is high, nitric oxide can be continuously released, growth of endothelial cells at the vascular anastomosis position is promoted, adhesion of platelets is inhibited, artery anastomosis operation in the main artery operation process can be effectively simplified, and the anastomosis effect is good. The endothelialization process of the blood vessel at the anastomotic stoma can be promoted, and the long-term patency rate of the blood vessel is increased.