Nitric oxide generating formulations and kits

A kit and nitric oxide technology, which can be applied to medical preparations without active ingredients, medical preparations containing active ingredients, catheters, etc., can solve problems such as reducing immune response
CN109069701APending Publication Date: 2018-12-21RGT UNIV OF MICHIGAN
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
RGT UNIV OF MICHIGAN
Publication Date
2018-12-21

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Abstract

An example of a nitric oxide generating formulation includes an S-nitrosothiol (RSNO) powder, a salt, and an additive. The additive is to control or accelerate a rate of release of nitric oxide (NO) from RSNO after the RSNO powder, the salt, and additive are dissolved into a liquid carrier. The nitric oxide generating formulation may be part of a kit that includes a container for dissolving the components into a liquid carrier. One of the kits may be used to prevent and / or treat sinonasal infections and another of the kits may be used to create antimicrobial lock solutions.
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Description

[0001] Cross References to Related Applications

[0002] This application claims the benefit of US Provisional Application Serial No. 62 / 299,850, filed February 25, 2016, the contents of which are hereby incorporated by reference in their entirety. Background of the invention

[0003] In humans, nitric oxide (NO) can be produced by any of several isoforms of the enzyme nitric oxide synthase (NOS). NO is important for mammalian immune response or defense, and is responsible for the killing of Leishmania major by macrophages ( L. major ), Mycobacterium bovis ( M. bovis ) and Mycobacterium tuberculosis ( M. tuberculosis ) as well as cytotoxic agents in mechanisms used by many other species of bacteria. NO is also a potent antiviral agent, active against rhinoviruses that cause the common cold. NO is produced by immune cells (macrophages, neutrophils, lymphocytes, etc.) respiratory tract) from L-arginine. Defective NO production can lead to reduced immune responses and / or ...

Claims

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