38 results about "NASAL PREPARATIONS" patented technology

A nasal spray formulation for use in female contraception or in the treatment of benign gynecological disorders is described. The nasal preparation is comprised of a GnRH compound and an estrogenic compound in the form of a water-soluble complex with a water-soluble cyclodextrin. The preparation effectively suppresses ovarian estrogen and progesterone production, and prevents signs and symptoms of estrogen deficiency, without a significant increase in the risk of endometrial hyperplasia.

The invention discloses a medicament for treating cardiovascular and cerebrovascular diseases, which is prepared from original-shaped medicament of Breviscapine or its pharmaceutically acceptable salts as the active constituents. The medicament can be made into nasal preparation, wherein each 1g of the medicament contain 1-200mg of the active constituents

The invention provides a gastrodin nasal starch microsphere with bioadhesive properties. The microsphere is prepared by the following method: using starch sodium hydroxide aqueous solution as the water phase; dispersing gastrodin in ethyl acetate to obtain Oil phase; slowly add the oil phase to the water phase at room temperature, and stir in the same direction to obtain O / W colostrum; heat the liquid paraffin containing Span80 to 40-50°C, add the above colostrum into it, and stir in the same direction to emulsify After 20-40 minutes, add the cross-linking agent epichlorohydrin, cross-link at 30-50°C for 3-5 hours, centrifuge, pour off the upper oil phase, and wash the lower layer of microspheres with ethyl acetate, absolute ethanol, and acetone respectively Finally, dry under reduced pressure to obtain the described gastrodin nasal starch microspheres; the gastrodin nasal starch microspheres prepared by the present invention have a long retention time in the nasal cavity, and the drug release speed is stable and complete, which can improve the drug distribution in the brain, biological Utilization and efficacy, and safe and non-toxic.

The invention belongs to the field of pharmaceutical preparations, and discloses a chitosan lipoprotein intranasal administration nanocomposite, comprising lipoprotein nanoparticles, chitosan or / and chitosan derivatives having the effect of promoting absorption of nasal mucosa. The invention also discloses a preparation method of chitosan lipoprotein intranasal administration nanocomposite, comprising: self-assembling chitosan or / and chitosan derivatives and lipoprotein nanoparticles through dynamic force to form a good membrane permeability nasal preparations. The preparation condition of the chitosan lipoprotein intranasal administration nanocomposite is mild, the process is simple, and the industrialized production is easy. The system is safe, non-toxic, and has good biodegradability, which can improve the absorption of lipoprotein drugs in the nasal mucosa and ensure high-efficiency brain targeting. The dosage form is administered by nasal drops, sprays, etc., and is easy to operate, convenient for patients who take the medicine for a long time, and has a good clinical application prospect in the treatment of central nervous system diseases.

The invention discloses a medicament for treating cardiovascular and cerebrovascular diseases, which is prepared from original-shaped medicament of Breviscapine or its pharmaceutically acceptable salts as the active constituents. The medicament can be made into nasal preparation, wherein each 1g of the medicament contain 1-200mg of the active constituents

The invention discloses a composition for constituting the in-situ gel spray for huperzine turbinitis, as well as its preparation method and application. The preparation is a nasal preparation which is in a liquid state in vitro and becomes a gel state when sprayed into a nasal cavity. It uses huperzine A as the active ingredient, supplemented with in-situ gel forming agent, isotonic regulator, pH regulator, preservative, water, etc. It is a nasal in-situ gel spray, which is suitable for the prevention and treatment of elderly people Dementia and middle-aged and elderly memory impairment or improve the memory and learning ability of adolescents. The nasal preparation is in a liquid state in vitro, the dosage is easy to accurately control, and it is convenient to use. When sprayed into the nasal cavity, it can be evenly dispersed on the surface of the nasal mucosa, and diffuses with the nasal mucus to form a gel, which stays in the nasal cavity for a long time and is not easy to be lost. The bioavailability of cerebrospinal fluid, brain, and hippocampus is 2.2 to 2.7 times that of oral administration, and the drug effect is 2 to 4 times that of oral administration. It has small local irritation, low toxicity, and good biocompatibility.