13 results about "NASAL PREPARATIONS" patented technology

The utility model discloses a device for measuring the residence time of a nasal preparation in nasal mucosa, which comprises a test plate with a plurality of test channels, a constant-temperature base and optionally a transparent cover body. The test channel is covered with a carrier for bearing nose simulation liquid, the constant-temperature base is hollow, a water inlet is formed in one side of the bottom end of the constant-temperature base, a water outlet is formed in one side of the top end of the constant-temperature base, so that a constant-temperature medium can pass through, and a device for displaying temperature is arranged on the test plate or the constant-temperature base. By adopting the novel device for measuring the residence time of the nasal preparation in the nasal mucosa, the nasal cavity environment including temperature, humidity, mucosa surface liquid composition, the inclination angle between the nasal cavity structure and the face and the like can be simulated to a certain extent, and prescription comparison with high flux and good parallelism can be carried out, so that development and evaluation of the nasal preparation are efficiently assisted.

The application belongs to the technical field of medicines, and particularly relates to application of alpha-asarone in preparation of a medicine for treating allergic rhinitis. The application aims at the problems of single drug target, prominent safety hazards and inability to block pathological progress from the root in the existing medicines for treating allergic rhinitis, takes alpha-asarone as an active ingredient, inhibits excessive activation of an inflammation pathway by activating an Nrf2 / HO-1 signal axis, and bidirectionally regulates expression balance of GPX4 and ACSL4 to inhibit ferroptosis and damage of a nasal epithelial barrier. Animal experiments prove that the alpha-asarone can significantly reduce allergic behaviors of model mice, relieve inflammation of nasal mucosa, reverse tissue remodeling, has high safety, and can be prepared into oral or nasal preparations, and provides a new treatment scheme with multiple target points for allergic rhinitis.

The present invention relates to nasal formulations for non-invasive delivery comprising a hemostatic agent and a super absorbent polymer in a powder form, and to uses of said formulations for preventing and / or treating epistaxis.

The present application relates to the field of biopharmaceuticals and specifically provides a neurotoxin-containing freeze-dried powder and a nasal formulation. The freeze-dried powder comprises a neurotoxin, and further comprises a stabilizer and an excipient. The excipient comprises one or more of acidic gelatin, alkaline gelatin, and sucrose. The stabilizer comprises one or more of block polyether F-68, block polyether F-127, and Tween 80. The use of the stabilizer comprising one or more of block polyether F-68, block polyether F-127, and Tween 80 and the excipient comprising one or more of acidic gelatin, alkaline gelatin, and sucrose produces a synergistic effect, such that the stability of the neurotoxin at room temperature is significantly improved, thereby slowing down the degradation of the neurotoxin, and significantly extending the period during which the bioactivity of the neurotoxin is maintained at 95% or higher. Moreover, the formulation can be nasally administered to increase the delivery of the neurotoxin across the blood-brain barrier and greatly reduce the toxicity.

The invention relates to the technical field of nasal preparation administration devices, in particular to a nasal dry powder inhalation administration device for children, which comprises a shell, an extrusion sealing mechanism, an auxiliary administration mechanism and a dose dividing mechanism. Wherein the dose dividing mechanism can realize accurate dose dividing and quantitative control of medicine powder according to physiological characteristics and medication requirements of children of different age groups; the auxiliary drug delivery mechanism is connected to the drug outlet end of the drug delivery pipe, the drug delivery path can be optimized according to the structural characteristics of the nasal cavity of a child, drugs are effectively guided to be deposited in the absorption area of the nasal cavity, and waste of the drugs in non-absorption areas such as the nasal vestibule is reduced; the extrusion sealing mechanism can stably spray out medicine powder in the shell through the medicine feeding pipe, and the medicine powder cooperates with the auxiliary medicine feeding mechanism, so that the delivery efficiency of the medicine in the nasal cavity is improved.

The present application relates to the technical field of neuropharmacology and psychiatry, and discloses a nasal drug composition, which comprises a therapeutically effective dose of a 5-HT1D receptor antagonist or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable cyclodextrin or a derivative thereof; the composition is a nasal preparation, and after nasal administration, the elimination half-life of the 5-HT1D receptor antagonist in brain tissue is longer than that in plasma, or the 5-HT1D receptor antagonist is preferentially retained in brain tissue. The present application combines the 5-HT1D receptor antagonist, the specific cyclodextrin inclusion technology and the nasal administration route, only makes the poorly soluble CNI3176 into a high-concentration (such as 1 mg / mL) clear solution, significantly improves the physical and chemical stability of the preparation, and enables the drug to reach the brain target in a few minutes (Tmax≤0.1 h), thereby providing a new type of anti-anxiety treatment solution which is rapid in effect, significant in curative effect, low in side effect risk and possible to avoid tolerance.

The invention discloses an ROS response type acupoint targeting traditional Chinese medicine microneedle patch as well as a preparation method and application thereof, and belongs to the technical field of microneedle patches. In combination with the principles of nasal mucosa physiology, acupoint anatomy and inflammatory pathology, the invention aims to solve the problems of short residence time, low bioavailability and incapability of on-demand administration of the traditional nasal preparation in a minimally invasive and intelligent transmucosal / transdermal administration mode. Aiming at the pathological characteristics that the nasal cavity moist environment, the skin cuticle barrier and the level of local reactive oxygen species (ROS) in the rhinitis attack period are increased, through the combination of the soluble microneedle array and the ROS responsive intelligent material, the precise, long-acting and on-demand release of the medicine at the acupuncture point or mucous membrane targeted part is realized; the painless experience and the treatment compliance of the patient are considered while the curative effect is improved.

This invention belongs to the field of traditional Chinese medicine technology, specifically relating to a nasal preparation, its preparation method, and its application. This invention uses ferulic acid, an effector component obtained through extraction and purification of Ligusticum chuanxiong, as the active pharmaceutical ingredient, combined with pharmaceutical excipients, to prepare a traditional Chinese medicine nasal preparation for intranasal administration. Animal experiments have demonstrated that the nasal preparation provided by this invention has significant relieving and therapeutic effects on tension-type headaches. Furthermore, as a topical liquid preparation, the preparation is stable, non-irritating to the administration site, and exhibits good compliance, showing promising clinical application prospects. It represents a new option for nasal preparations in the field of traditional Chinese medicine for treating tension-type headaches.

The invention provides a temperature-sensitive hydrogel preparation for treating brain hypoxia related diseases, the active ingredient of the temperature-sensitive hydrogel preparation is a ligustilide cyclodextrin inclusion compound, and the temperature-sensitive hydrogel preparation is prepared from ligustilide and hydroxypropyl-beta-cyclodextrin through an inclusion effect. Compared with the prior art, the invention has the following advantages: the cyclodextrin inclusion technology can effectively improve the problems of low stability, poor solubility and the like of ligustilide, and the poloxamer temperature-sensitive hydrogel has good stability, biocompatibility and slow release performance. The cyclodextrin inclusion compound and the hydrogel are combined to be applied to the nasal preparation, after the temperature-sensitive hydrogel enters the nasal cavity, the gel form at the physiological temperature is converted into a semi-solid and is adsorbed on the nasal mucosa, the residence time of the medicine at the administration position is prolonged, the slow release effect is achieved, meanwhile, the administration dosage can be reduced, the side effect of the medicine is relieved, and the bioavailability of the medicine is improved. The compound can be used for various brain diseases, is expected to overcome the defects of the traditional nasal preparation, and improves the curative effect of the medicine and the acceptability of a patient.

The invention relates to an aerosol model analyzer, which relates to the technical field of inhalation and nasal preparation spray characteristic determination and evaluation equipment, and comprises a protection device, a trigger device, a laser device, an imaging device and a control analysis device, the protection device is used for providing a dark environment for the laser device and the imaging device; the triggering device is used for triggering the nasal preparation or the inhalation aerosol preparation; the laser device is arranged opposite to the trigger device and is configured to irradiate spray formed by the trigger device and form a laser lamp plate when the trigger device works; and the imaging device is used for shooting the spray. According to the aerosol model analyzer, the aerosol model analyzer capable of accurately measuring the inhalation and nasal preparation spraying mode and plume geometry and analyzing parameters is arranged, so that the requirements of analysis and test of the inhalation aerosol preparation and the inhalation aerosol preparation are met.

The invention belongs to the technical field of medicine analysis, and relates to a method for detecting the medicine particle size distribution of a suspension type preparation. The suspension type preparation contains microcrystalline cellulose-sodium carboxymethyl cellulose. Providing an ammonia solution of copper tetraammine as a pretreatment solvent; adding a suspension preparation into the pretreatment solvent, and fully mixing to completely dissolve the auxiliary material comprising microcrystalline cellulose-sodium carboxymethyl cellulose to obtain a mixed solution; carrying out solid-liquid separation on the mixed solution, and collecting a solid obtained after solid-liquid separation, namely a raw material medicine; adding a solid obtained after solid-liquid separation into a dispersing agent, and carrying out pulsed ultrasonic dispersion to obtain a suspension; and carrying out laser particle size detection on the suspension. The detection method can accurately detect the particle size distribution of the active components in the suspension type nasal preparation, and has the characteristics of high precision, high specificity, high sensitivity and the like, so that reliable technical support is provided for research and development and quality control of the suspension type preparation.

The present invention relates to the field of pharmaceutical preparations, and in particular to a composition of a nalmefene hydrochloride nasal preparation and a preparation method therefor. The nalmefene hydrochloride nasal preparation comprises: nalmefene hydrochloride or a hydrate thereof and dodecylphosphorylcholine. A product of the nalmefene hydrochloride nasal preparation is absorbed by the nasal cavity rapidly, so that the problems of inconvenient administration and slow onset of existing preparations are solved, and the technical effect of providing safe, effective, and convenient clinical use is realized.

The invention discloses a nasal preparation prepared from penehyclidine hydrochloride and application of the nasal preparation in treatment of rhinitis diseases. The upper respiratory tract is infected by bacteria and viruses or stimulated by foreign matters (such as pollen, hair, dust, cold air and the like), so that clinical symptoms such as sneezing, nasal obstruction, running nose and the like occur in the nasal cavity, namely acute rhinitis or chronic rhinitis diseases are caused. The medicine for treating the rhinitis disease is a medicine preparation such as nose drops, spray and the like prepared by taking a penehyclidine hydrochloride compound as a main component and adding pharmaceutically acceptable auxiliary components, the administration route is nasal local administration, and the weight-volume ratio of penehyclidine hydrochloride to the auxiliary components is (1: 250)-(1: 10000). The application field of the penehyclidine hydrochloride compound is widened, a novel medicine is provided for specific people with rhinitis symptoms, and the novel medicine adopts local administration and has the advantages that active ingredients directly reach focus parts, the medicine takes effect quickly, the local bioavailability is high, the duration time is long, the dosage is small, and the occurrence rate of adverse reactions is greatly reduced.