Nasal gel or ointment preparation for preventing and/or treating aspiration allergy

A technology of gel and ointment, applied in the field of nasal preparations, which can solve the inconvenience of patients and achieve the effect of eliminating or alleviating allergic symptoms

Inactive Publication Date: 2012-11-07
SHANGHAI SHYNDEC PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For allergens in the air such as pollen, dust mites, dust, mold and other allergens, wearing a mask is an effective preventive method. It can significantly reduce the contact between the allergens in the air and th

Method used

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  • Nasal gel or ointment preparation for preventing and/or treating aspiration allergy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] See the following table 1 for the weight proportion of the nasal gel or ointment preparation for the prevention and / or treatment of inhalation allergy:

[0024] Table 1

[0025] White Vaseline 800g glycerin 100g Glyceryl monostearate 100g Made into 1000g

[0026] Preparation process: Weigh white vaseline, glycerin, and glyceryl monostearate according to the prescription amount, put them in a jacketed tank, heat to 90°C-95°C, and stir to melt them all. 160 mesh screen filter. Cool to a suitable filling temperature, fill, and get ready.

[0027] According to the Chinese Pharmacopoeia 2010 edition (appendix VI C third method), the melting point of this product is 51°C.

[0028] According to the Chinese Pharmacopoeia 2010 edition (Appendix X K), the cone penetration of this product is 135.

[0029] Take an appropriate amount of this product and apply it to the inner wall of the nasal cavity, which is easy to apply without discomfor...

Embodiment 2

[0031] See the following table 2 for the weight proportion of the nasal gel or ointment preparation for the prevention and / or treatment of inhalation allergy:

[0032] Table 2

[0033] White Vaseline 990g silicone oil 5g Polyoxyester S40 5g Made into 1000g

[0034] Preparation process: Weigh white petrolatum, silicone oil, and solid paraffin respectively according to the prescription amount, put them in a jacketed tank, heat to 80°C-90°C, and stir to melt them all. 160 mesh screen filter. Cool to a suitable filling temperature, fill, and get ready.

[0035] According to the Chinese Pharmacopoeia 2010 edition (appendix VI C third method), the melting point of this product is 61°C.

[0036] According to the Chinese Pharmacopoeia 2010 edition (Appendix X K), the cone penetration of this product is 187.

[0037] Take an appropriate amount of this product and apply it to the inner wall of the nasal cavity, which is easy to apply without di...

Embodiment 3

[0039] See the following table 3 for the weight proportion of the nasal gel or ointment preparation for the prevention and / or treatment of inhalation allergy:

[0040] White Vaseline 950g glycerin 45g solid paraffin 5g Made into 1000g

[0041] Preparation process: Weigh white vaseline, glycerin, and solid paraffin respectively according to the prescription amount, put them in a jacketed tank, heat to 90°C-100°C, and stir to melt them all. 160 mesh screen filter. Cool to a suitable filling temperature, fill, and get ready.

[0042] According to the Chinese Pharmacopoeia 2010 edition (appendix VI C third method), the melting point of this product is 63°C.

[0043] According to the Chinese Pharmacopoeia 2010 edition (Appendix X K), the cone penetration of this product is 180.

[0044] Take an appropriate amount of this product and apply it to the inner wall of the nasal cavity, which is easy to apply without discomfort.

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Abstract

The invention relates to a nasal preparation for preventing and/or treating aspiration allergy. With white vaseline as a matrix, the nasal gel or ointment preparation provided by the invention contains coating-extensibility pharmaceutic adjuvants required for adjustment of the gel or ointment preparation. When the nasal gel or ointment is smeared on the inner wall of nasal cavity, a layer of protective film, like an invisible mouth mask, is formed in the nasal cavity, thus effectively blocking inhalant allergens (such as pollen in the air and the like) from entering human body through the nasal cavity. Thereby, allergy symptoms are eliminated or alleviated, and the nasal gel or ointment containing drug components further can simultaneously play the role of drug treatment as well.

Description

technical field [0001] The present invention relates to a nasal preparation for preventing and / or treating inhalation allergy. Background technique [0002] Allergies are common and are usually caused by inhaling or ingesting a sensitive allergen. Inhalation allergy is caused by pollen, dust mites, dust, mold and other inhaled allergens in the air entering the nasal cavity and trachea, stimulating the body to release histamine and other substances, causing allergic symptoms such as sneezing, runny nose, nasal itching and nasal congestion . Classic allergies include hay fever, which is caused by inhalation of airborne pollen and often triggers acute seasonal allergic rhinitis or even asthma. Dust, mites, and animal dander are also common inhalant allergens and are common triggers of perennial allergic rhinitis. [0003] There are various options for treating inhalant allergies. The allergic rhinitis treatment system recommended by the World Health Organization is mainly c...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K9/00A61K47/44A61K45/06A61K45/00A61P37/08A61P11/02A61P11/06
Inventor 王永祥邹凌燕
Owner SHANGHAI SHYNDEC PHARMA CO LTD
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