Tetrandrine nasal preparation for treating post-traumatic stress disorder
A post-traumatic stress, tetrandrine technology, applied in the directions of non-active ingredients medical preparations, medical preparations containing active ingredients, aerosol delivery, etc., can solve the discomfort of blood and lymphatic system, side effects can not be ignored, Sexual dysfunction and other problems, to achieve the effects of strong bioadhesion, prolonged residence time, and less toxic and side effects
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Embodiment 1
[0030] Embodiment one: tetrandrine nasal suspension preparation
[0031] Take 2g of poloxamer 188 and 12g of poloxamer 407, add appropriate amount of water to fully swell at 4°C, continue to add water to 50ml, and mix well to obtain a temperature-sensitive gel; take 1g of tetrandrine, add 6ml of 1,2 - Propylene glycol and 8ml of ethanol, mixed evenly; add the above-mentioned tetrandrine suspension to 36ml of the above-mentioned temperature-sensitive gel, and mix well to obtain a tetrandrine nasal preparation.
Embodiment 2
[0032] Example 2: Tetrandrine nasal cubic liquid crystal
[0033] 1. Prescription
[0034]
[0035] 2. Preparation process
[0036] Keep the water bath at a constant temperature of 45°C, weigh 3.2g of glycerol monooleate and put it in a 50ml centrifuge tube, add 0.3g of ethanol, put the centrifuge tube in a beaker in the water bath and heat it in a water bath, until the glycerol monooleate in the centrifuge tube The ester completely melted to a clear transparent solution. Put 0.75g of tetrandrine and 1.5g of water in a beaker and mix evenly, and heat at 45°C in a water bath. Hold the centrifuge tube on the vortex mixer, use a 1ml syringe to absorb the tetrandrine suspension, and quickly add it drop by drop until the liquid in the centrifuge tube gradually thickens, continue to stir, and continue to add the remaining solution dropwise.
Embodiment 3
[0037] Example 3: Cubic liquid crystal for tetrandrine nasal use
[0038] Precisely weigh 3.2g glycerol monooleate and place it in a centrifuge tube, put the centrifuge tube into a 45°C constant temperature water bath and heat until the glycerol monooleate is completely melted, add 0.3g ethanol, vortex to mix evenly, and use as oil Mutually. Add 0.1g tetrandrine, vortex again, draw 1.4g deionized water preheated to 45°C with a 1ml syringe, add water dropwise to the oil phase while vortexing, stir evenly with a glass rod, and place it at room temperature 7 days.
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