33results about How to "Strong bioadhesion" patented technology

The present invention relates to new technological process of aerobically composting sludge with suspended biological carrier normally used in sewage treatment as the amendment. The sludge material is added with wood dust in 5-15 wt% of sludge and suspending biological carrier stuffing in 5-10 wt% of sludge as the amendment to make the stirred material possess water content of 60-70 %. The aerobic fermentation apparatus is dynamically controlled I ventilation and stirring frequency for fast composing treatment. Finally, the suspending biological carrier stuffing is sieved out for reuse. The new amendment of the present invention has good attaching performance, no loss and reuse, and the present invention has high composing efficiency.

The invention discloses compound intrauterine infusion liquid of western medicine and Chinese traditional medicine for treating cow endometritis and a preparation method thereof, the infusion liquid takes oxytetracycline, motherwort herb, peach seed, Chinese angelica, Szechuan lovage rhizome, membranous milkvetch root, liquoric root and a plurality of excipients as raw materials and is prepared by decoction, filtration, concentration, pumping filtration, concentration, spray drying, micro-powderization of oxytetracycline, homogenization and other processes; the infusion liquid has the advantages that firstly, the raw materials constitute the safe, effective and comprehensive infusion liquid which can not only realize the rapid anti-inflammation, but can also restore the functions of the body with the diseases after the inflammation, promote the pregnancy and treat the infertility; secondly, the infusion liquid adopts the formulation of microparticle suspension, the unit solvent drug-loaded amount is great, the drug delivery volume is small, the chemical properties of the drug microparticles are stable, the bioadhesion is stronger, the drug release is sustained, the infusion liquid can be adhered on the cow uterine endometrium for a long time, thus directly stimulating a uterine receptor, ensuring the drug to be fully absorbed as well as better and rapidly playing the roles.

The invention discloses an MBBR slow release carbon filler and a preparation method thereof. The product provided by the invention has the advantages of fast biofilm formation speed, strong biologicaladhesion, difficult falling and high treatment efficiency, and is especially used for treatment of domestic sewage and industrial wastewater with high BOD5 content. The biological filler provided bythe invention has strong hydrophilicity and biological affinity, and the filler itself contains a slow-release carbon source, can provide the carbon source needed for biological metabolism, and the porous walnut sand material is beneficial to microbial growth, shortening of the biofilm formation time and improvement of the microbial treatment efficiency. With an ammonia nitrogen removal rate of greater than 92% and COD removal efficiency all exceeding 83%, compared with the existing filler, the MBBR slow release carbon filler provided by the invention can better treat biodegradable sewage.

The invention discloses the diatomite filler and the preparation method, which is composed by the followings based on the weight per centage: diatomite 83 per cent to 87 per cent, ferrous powder 8 per cent to 12 per cent and rice bran powder 4 per cent to 6 per cent. The diatomite, ferrous powder and rice bran powder are dried under constant temperature after mixing and dehydrated, and are added with the vesicant and binder to stir evenly and smash. The pelletizer is used to make the smashed materials spheric shape with diameter of 3mm to 6mm and the materials of spheric shape are calcined. During calcining, the coal is dried and grinded into powder and the air injection gear is used to spray the coal powder evenly on the materials of spheric shape. The diatomite filler is gained through sieving and grading after calcining. The diatomite filler of the invention has the advantages of being stronger in biological adhesion, strong in microorganism adhesion, richer in species, larger in specific area, high in porosity, stabler in water treatment facilities, less in energy consumption, light in weight and hard in wearing.

The invention discloses a nimodipine liposome for nasal delivery and a preparation method thereof, which belong to the field of pharmaceutic preparations. The nimodipine liposome for nasal delivery contains nimodipine and pharmaceutical effective auxiliary materials, wherein the concentration of the nimodipine is 2-9% w/v. The nimodipine liposome disclosed by the invention has the advantages that a nimodipine cyclodextrin inclusion compound flexible nano liposome is prepared according to the invention, so that the stability of the flexible nano liposome can be effectively improved, the direct exposure of nimodipine to nasal mucosa can be reduced, the toxic and side effects of drugs can be reduced, and the safety of nasal delivery can be improved; and the nimodipine liposome is absorbed rapidly, so that the nimodipine liposome can significantly improve the bioavailability of drugs, thereby facilitating the quick and full play of the pharmacologic action of nimodipine.

The invention discloses self-oxygenation microorganism degradation filler and a preparation method thereof. A product disclosed by the invention has a rapid film formation speed, strong biological adhesiveness, uneasiness of falling off and high treatment efficiency and is especially used for treating domestic sewage and industrial wastewater with relatively high BOD5 (Biochemical Oxygen Demand 5)content; the product disclosed by the invention has extremely strong hydrophilicity and biocompatibility; the filler contains an oxygen-carrying material and surface tension between air bubbles and awater surface can be reduced; oxygen can be dissolved into sewage and the growth of microorganisms is facilitated; the film formation time is shortened and the microorganism treatment efficiency is improved. The ammonia nitrogen removal rate is higher than 90 percent and the removal efficiency of COD (Chemical Oxygen Demand) exceeds 80 percent; compared with existing filler, the sewage with relatively high BOD5 content can be treated better.

The invention discloses an antiviral small nucleic acid and the application of the small nucleic acid in preparing a medicine for suppressing herpes simplex virus (HSV) and human papilloma virus (HPV). The small nucleic acid is a double strand nucleic acid, the positive-sense strand sequence is 5 in a sequence table, and the antisense strand sequence is 6 in the sequence table; the small nucleic acid can be prepared into a temperature-sensitive type gel preparation; the temperature-sensitive type gel preparation is injected (or sprayed) into irregular cavities such as vagina or mouth, the expression of host B2M genes in epithelial cells at the cavities and the cervix uteri and the expression of externalHPV E7 are suppressed, so that the antiviral small nucleic acid can be used for suppressing the infection of the HPV of the HSV-1 virus and/or for treating the precancerous lesions of uterine cervix caused by the HVP.

The invention relates to a chitosan/5-hydroxymethylfurfural composition preparation method. The method includes dissolving a chitosan substance by an acid aqueous solution to obtain a solution A, mixing the solution A with a solution containing 5-hydroxymethylfurfural to obtain a pre-reaction solution, adding alkali liquor into the pre-reaction solution to regulate a pH (potential of hydrogen) value of the pre-reaction solution, subjecting the pre-reaction solution to condensation reaction at a stirring speed of 100-500r/min at the temperature of 4-85 DEG C to obtain a gelatinous or flocculent chitosan/5-hydroxymethylfurfural composition, and subjecting the chitosan/5-hydroxymethylfurfural composition obtained after the reaction to dialysis treatment by deionized water prior to freeze drying so as to obtain a dry chitosan/5-hydroxymethylfurfural composition. By the aid of the chitosan/5-hydroxymethylfurfural composition prepared according to the chitosan/5-hydroxymethylfurfural composition preparation method, more -NH2 radical groups can be retained, so that more excellent unique antibacterial performance, biological adhesion performance and the like can be retained.

The invention relates to a biological stuffing for denitrification. The biological stuffing for denitrification comprises a spherical shell, wherein a plurality of meshes are formed in the surface of the shell, the shell is filled with a biological carrier stuffing, and the biological carrier stuffing is formed by combining two types of granular substance made from different materials. One granular substance is cuboid massive particles made from a nano modified polyurethane material, the other granular substance is porous mineral particles, and the filling rate of the biological carrier filler in the shell is 35%-85%. The biological stuffing for denitrification has the advantages that the biological stuffing for denitrification is large in specific surface area, high in porosity, high biological adhesion, high in biofilm formation speed, high in anti-load capacity, high in denitrification efficiency, small in biological sludge yield, good in chemical and biological stability and durable, enables biofilm formation to be easy, is resistant to aging, acid and alkali, can be arranged directly without fixing and is convenient to install, no harmful substance is not dissolved, and secondary pollution is not caused.

The present disclosure provides a composite dressing comprising a combination of porous matrix and fabric substrate wherein at least one of said porous matrix and fabric substrate is composed biomaterial(s) and wherein the fabric substrate is at least partially embedded in the porous matrix. Further, the disclosure provides a method for preparation of said composite dressing, wherein said method enables production of the composite dressing having cohesive bonding between porous matrix and fabric support without use of any adhesive, stitching or chemical crosslinking agent between the two layers. The composite dressing exhibits high peel strength in both dry and wet conditions and has applications such as hemostatic dressings for deep cavity wounds, puncture wounds, post-partum hemorrhage and internal hemostatic agents.

The present invention provides one kind of biologically degradable adhesive natural polymer polysaccharide microballoon, its preparation, treating composition and medicine administrating system carrier. The microballoon is prepared by an oil-water two-phase process including dispersing pectin and xanthan gum in oil phase, adding chitosan and polycarbophil to graft, separation, cleaning and drying. It is biologically degradable and has good biocompatibility and strong biological adhesion. It is used in orally taken biological macromolecular medicine administrating system to raise the biological utilization of medicine.

The invention discloses preparation and application methods of a highland barley beta-glucan-polyaspartic acid complex. The preparation method of the highland barley beta-glucan-polyaspartic acid complex comprises the following steps: after sufficiently swelling and dissolving highland barley beta-glucan and polyaspartic acid with water, adding ethylene glycol or glycerol and reacting at 80 DEG Cto 100 DEG C for a period of time; freezing and drying a reaction solution and putting freeze-dried powder into a saturated potassium bromide or saturated potassium iodide solution environment under the conditions that the temperature is 55 DEG C to 85 DEG C and the relative humidity is 65 percent to 85 percent and reacting for 10d to 20d to obtain the highland barley beta-glucan-polyaspartic acidcomplex. The complex disclosed by the invention can be applied to fields including cosmetic humectants and biological adhesive preparation type medicines. The preparation and application methods of the highland barley beta-glucan-polyaspartic acid complex have the advantage that the complex has good hmudity keeping performance and biological adhesive performance.

The invention relates to the technical field of antifungal drugs and specifically to a sustained-release miconazole nitrate gel and a preparation method thereof. The sustained-release miconazole nitrate gel is prepared from the following ingredients in parts by weight: 2-5 parts of miconazole nitrate, 0.1-1 part of polycarbophil, 0.5-2 parts of carbopol 934P, 5-7 parts of glycerin, 4-5 parts of liquid paraffin, 0.1-1 part of potassium sorbate, 0.1-1 part of methylparaben, 1-3 parts of glycerin behenate, and purified water added till 100 parts. The sustained-release miconazole nitrate gel of the invention is based on bioadhensive materials polycarbophil and carbopol as matrices for the gel, such that the local resistance time can be prolonged; the gel can be rapidly released to an effective dose and can be slowly released for continuous 12 h at the effective dose, and has the advantages of hydrophily, no greasiness, and the like.

The invention discloses melatonin slow-release nasal healthcare perfume with a sleep promoting efficacy and a preparation method. The healthcare perfume is prepared from the following raw materials in proportion by weight: 0.1 to 3 percent of melatonin, 1 to 5 percent of a traditional Chinese medicine additive with a nasal healthcare efficacy, 0.1 to 0.5 percent of santal mixed essence, 0.1 to 0.3 percent of a preservative, a proper amount of medicinal auxiliary materials, and slow-release auxiliary materials for the surplus. The healthcare perfume has efficacy of sleep promotion through the melatonin, has natural nasal healthcare efficacy through the additive, is diffused into the air in a perfume mode, is inhaled through respiratory tract nasal cavity, can bypass a blood brain barrier and enter the central nervous system, ensures that the maximum release amount is achieved after the perfume is used for 2 to 4 hours through release slow treatment, ensures that the concentration of the melatonin presents a high physical demand variation, and improves the sleep environment through different odor types of essences, thereby achieving the effect of sleep promotion and nasal health protection, and has the advantages that the perfume is convenient to carry, safe and non-toxic and nonirritating.

The invention discloses a fast infiltration system used for rural sewage treatment. The system is composed of an upper layer and a lower layer, wherein a lower-layer tank body is composed of a gratingditch, an oil removal sedimentation tank, an adjusting tank and a water outlet tank, an upper-layer tank body is a fast infiltration tank, the fast infiltration system used for rural sewage treatmentis further provided with an external fan, the fast infiltration tank comprises a water collection layer and a plurality of infiltration layers from bottom to top, the water collection layer comprisesa water gathering layer, a middle bearing board and a dephosphorization layer from bottom to top in sequence, the water gathering layer is connected with a water outlet tank through a water gatheringpipe, the infiltration layers comprise bottom bearing boards, lower infiltration layers, transition layers and fast filtering layers from bottom to top in sequence, air distributing pipes are arranged on the lower infiltration layers, each air distributing pipe is connected with an air distribution header pipe, an air source is from the external fan, water distribution pipes are arranged on the fast filtering layers, and each water distribution pipe is connected with a water distribution header pipe; a reflux pump is arranged in the water outlet tank. By means of the fast infiltration systemused for rural sewage treatment, the concentration of pollutants which enter the fast infiltration tank is reduced, sewage short flows, orifice blocking and filler hardening are reduced, and maintenance workloads of workers are reduced.

The invention relates to the technical field of water body restoration, in particular to a WPMPA combined device and method for restoring ecological balance of a water body. A rotating disc is rotatably connected to the upper surface of a supporting base, a protective frame is movably connected to the outer surface of the rotating disc, a pushing base is movably connected to the interior of the protective frame, an extrusion base is movably connected to the side surface of the pushing base, an air pressure bag is movably connected to the side surface of the extrusion base, a compression springis movably connected to the outer surface of the protection frame, a supporting rod is movably connected to the side surface of the compression spring, mounting frames are fixedly connected to the left side and the right side of the supporting base correspondingly, and a movable disc is rotatably connected to the interior of the mounting frame, the outer surface of the movable disc is rotatably connected with a meshing toothed bar, and the side surface of the movable disc is movably connected with a movable rod. Purification of the water quality can be quickened, under the action of microorganisms, the self-purification capacity of the water quality is improved, and the treatment of the ecological balance of the water body is improved.

The invention provides a composition and ointment for treating bromhidrosis and preparation processes of the composition and ointment, and relates to the technical field of medicine for treating bromhidrosis. On one hand, the invention provides the composition for treating bromhidrosis, the composition mainly comprises schisandra chinensis, ephedra root and other components, and can soothe liver, clear heat, remove dampness, resolve turbidity and resist bacteria, so that the purpose of treating bromhidrosis is achieved. On one hand, the invention provides a preparation process of the composition for treating bromhidrosis, and the process can improve the effectiveness of the medicine, and excessive irritation and allergy to skin, mucous membranes and the like are avoided. On one hand, the invention also provides an ointment for treating bromhidrosis, and the ointment comprises the composition and a gel matrix, the ointment is convenient for a user to carry, and the gel matrix has strong air permeability and biological adhesion effect and can accelerate the absorption of the skin to the medicine. On the other hand, the invention provides a preparation process of the ointment for treating bromhidrosis, and the process enables the gel matrix of the ointment to be higher in strength and better in stability.

The invention discloses an antiviral double-stranded RNA and application of temperature-sensitive type gel prepared by the same in treating and preventing HSV-1 caused diseases. One strand of the double-stranded RNA is of a sequence 1 in the sequence table and the other strand thereof is of a sequence 2. Modified compound of the double-stranded RNA refers to substance obtained by chemically modifying the double-stranded RNA with 2' fluoro, 2' methoxyl, sulpho or 2' deoxidization or modifying the double-stranded RNA with cholesterol. According to tests, the temperature-sensitive type gel which is applied to skins and comprises active ingredient namely the double-stranded RNA can suppress foreign HSV-1expression of epithelial cells of the skins; thus, the temperature-sensitive type gel is applied to suppression of HSV-1 virus infection and treatment of HSV-1 caused diseases.