Nimodipine liposome for nasal delivery and preparation method thereof

A technology for nimodipine lipid and intranasal administration, applied in the field of pharmaceutical preparations, can solve problems such as limited improvement of drug absorption, and achieve the effects of avoiding or reducing irritant toxicity, low irritation, and improving therapeutic effect
CN104706597AActive Publication Date: 2015-06-17TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE
Publication Date
2015-06-17

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Abstract

The invention discloses a nimodipine liposome for nasal delivery and a preparation method thereof, which belong to the field of pharmaceutic preparations. The nimodipine liposome for nasal delivery contains nimodipine and pharmaceutical effective auxiliary materials, wherein the concentration of the nimodipine is 2-9% w / v. The nimodipine liposome disclosed by the invention has the advantages that a nimodipine cyclodextrin inclusion compound flexible nano liposome is prepared according to the invention, so that the stability of the flexible nano liposome can be effectively improved, the direct exposure of nimodipine to nasal mucosa can be reduced, the toxic and side effects of drugs can be reduced, and the safety of nasal delivery can be improved; and the nimodipine liposome is absorbed rapidly, so that the nimodipine liposome can significantly improve the bioavailability of drugs, thereby facilitating the quick and full play of the pharmacologic action of nimodipine.
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Description

technical field

[0001] The invention relates to a nimodipine liposome for nasal administration and a preparation method thereof, belonging to the field of pharmaceutical preparations. Background technique

[0002] Nimodipine (Nimodipine, NM) is a dihydropyridine calcium ion antagonist with strong selective expansion of cerebrovascular effect. It has a good therapeutic effect on diseases such as stroke, sudden deafness, and brain dysfunction caused by chronic cerebrovascular disease. However, due to the poor water solubility of NM and the serious first-pass effect, the bioavailability of oral preparations such as tablets and capsules is low, and the average bioavailability is only 5-20%. In order to maintain the curative effect, patients need large doses and frequent medication. This not only increases the toxic and side effects of the drug, but also the concentration of nimodipine transported into the brain after oral administration is easily affected by changes in physiolo...

Claims

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