Antifungal imidazole medicament controlled-release gel and preparation method thereof

Abstract

The invention discloses a preparation method of an antifungal imidazole medicament controlled-release gel. The preparation is mainly used for vaginal administration and treatment on colpomycosis and other diseases and belongs to the technical field of medicaments. The antifungal imidazole medicament controlled-release gel is prepared from the following raw materials in parts by weight: 0.5-3 parts of imidazole medicaments, 0.5-2 parts of polycarbophil, 0.5-2 parts of carbomer, 0.2-1.0 part of lipid component, 1-2 parts of emulsifying agent, 5-15 parts of wetting agent and 80-100 parts of water. The preparation method has the advantages that the medicament is slowly released, local durable concentration of the medicament is kept, the sterilizing effect is enhanced, the medicament application frequency is reduced, and the stimulation to the medicament is reduced.

Description

technical field

[0001] The invention relates to an antifungal imidazole slow-release gel and a preparation method thereof. The preparation is mainly used for vaginal administration and local treatment of diseases such as candida vulvovaginosis and double infection caused by Gram-positive bacteria, and belongs to field of pharmaceutical technology. Background technique

[0002] Imidazole drugs are currently the most widely used antifungal drugs in the world, mainly including miconazole nitrate, econazole nitrate, butoconazole nitrate, ketoconazole and clotrimazole, which are synthetic imidazole broad-spectrum antifungal drugs. Drugs have almost all effects on pathogenic fungi. Its mechanism is to inhibit the synthesis of sterols in the fungal cell membrane, affect the permeability of the cell membrane, inhibit the growth of fungi, and lead to their death. The concentration below 4mg / L can inhibit most clinically isolated fungi. In addition, miconazole is also effective agai...

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