Sustained-release miconazole nitrate gel and preparation method thereof

A technology of miconazole nitrate and sustained-release gel, which is applied in pharmaceutical formulations, medical preparations without active ingredients, and medical preparations containing active ingredients, etc. The problem of weak mucosal capacity, etc., achieves the effect of reliable method principle and wide application prospect.
CN106265486AInactive Publication Date: 2017-01-04滨州医学院附属医院
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
滨州医学院附属医院
Publication Date
2017-01-04
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to the technical field of antifungal drugs and specifically to a sustained-release miconazole nitrate gel and a preparation method thereof. The sustained-release miconazole nitrate gel is prepared from the following ingredients in parts by weight: 2-5 parts of miconazole nitrate, 0.1-1 part of polycarbophil, 0.5-2 parts of carbopol 934P, 5-7 parts of glycerin, 4-5 parts of liquid paraffin, 0.1-1 part of potassium sorbate, 0.1-1 part of methylparaben, 1-3 parts of glycerin behenate, and purified water added till 100 parts. The sustained-release miconazole nitrate gel of the invention is based on bioadhensive materials polycarbophil and carbopol as matrices for the gel, such that the local resistance time can be prolonged; the gel can be rapidly released to an effective dose and can be slowly released for continuous 12 h at the effective dose, and has the advantages of hydrophily, no greasiness, and the like.
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Description

technical field

[0001] The invention relates to the technical field of antifungal drugs, in particular to a miconazole nitrate sustained-release gel and a preparation method thereof. Background technique

[0002] Miconazole nitrate is an antifungal drug. This product can inhibit the growth of most fungi at a certain concentration. Blastomyces and Histoplasma are highly sensitive to it. Cryptococcus, Candida, Coccidioides, etc. It is also sensitive to this product. Gynecology is mainly used for vaginal infections caused by Candida and repeated infections caused by Gram-positive bacteria. The traditional vaginal dosage forms of miconazole nitrate, such as ointment and suppository, have a relatively large oil-water partition coefficient and weak ability to penetrate the skin and mucous membranes; ordinary gel dosage forms have a short residence time at the site of action and require multiple administrations within a day, which not only affects the Curative effect, also brings ...

Claims

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