Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Sustained-release miconazole nitrate gel and preparation method thereof

A technology of miconazole nitrate and sustained-release gel, which is applied in pharmaceutical formulations, medical preparations without active ingredients, and medical preparations containing active ingredients, etc. The problem of weak mucosal capacity, etc., achieves the effect of reliable method principle and wide application prospect.

Inactive Publication Date: 2017-01-04
滨州医学院附属医院
View PDF6 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The traditional vaginal dosage forms of miconazole nitrate, such as ointment and suppository, have a relatively large oil-water partition coefficient and weak ability to penetrate the skin and mucous membranes; ordinary gel dosage forms have a short residence time at the site of action and require multiple administrations within a day, which not only affects the curative effect, but also bring a lot of inconvenience to patients

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Sustained-release miconazole nitrate gel and preparation method thereof
  • Sustained-release miconazole nitrate gel and preparation method thereof
  • Sustained-release miconazole nitrate gel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] A kind of miconazole nitrate slow-release gel, take the medicine of following quality: miconazole nitrate 3g, polycarbophil 0.3g, carbopol 934P 0.7g, glycerin 5.5g, liquid paraffin 4g, potassium sorbate 0.3g , methylparaben 0.3g, glyceryl behenate 1g, add purified water to 100g.

[0028] Carry out the following steps for the weighed medicine: a: Take 0.3g of polycarbophil and 0.7g of Carbopol 934P, add an appropriate amount of purified water and soak for 10 hours, stir well until it swells completely into a uniform gel-like polymer, and then add sorbic acid Potassium nitrate 0.3g, methylparaben 0.3g and miconazole nitrate 3g were stirred and mixed evenly; b: heating glycerin 5.5g, liquid paraffin 4g and glyceryl behenate 1g to make it melt, fully stirred to obtain a uniform oil Phase; c: Add B to A quickly while it is hot, stir to mix the two phases thoroughly to obtain a uniform turbid liquid, and stir to the prescription amount while adding purified water. Add 10mg.m...

Embodiment 2

[0030] A kind of miconazole nitrate slow-release gel, get the medicine of following quality: miconazole nitrate 4g, polycarbophil 1g, carbopol 934P 1.5g, glycerin 7g, liquid paraffin 5g, potassium sorbate 0.8g, nitric acid Parkin methyl ester 0.8g, glyceryl behenate 3g, add purified water to 100g.

[0031] Carry out the following steps for the weighed medicine: a: Take 0.5 part of polycarbophil, 1 part of Carbopol 934P, add appropriate amount of purified water and soak for 10 hours, stir well until it is completely swollen into a uniform gel-like polymer, and then add sorbic acid 0.5 parts of potassium phosphate, 0.2 parts of methylparaben and 3 parts of miconazole nitrate were stirred and mixed evenly; b: heating 6.5 parts of glycerin, 4.5 parts of liquid paraffin and 2 parts of glyceryl behenate to melt, and fully stirred to obtain Uniform oil phase; c: quickly add B to A while hot, stir to mix the two phases thoroughly to obtain a uniform turbid liquid, add purified water w...

Embodiment 3

[0033] A kind of miconazole nitrate slow-release gel, get the medicine of following quality: miconazole nitrate 3g, polycarbophil 0.5g, carbopol 934P 1g, glycerin 6.5g, liquid paraffin 4.5g, potassium sorbate 0.5g , methylparaben 0.2g, glyceryl behenate 2g, add purified water to 100g.

[0034] Carry out the following steps for the weighed medicine: a: Take 0.5 part of polycarbophil, 1 part of Carbopol 934P, add appropriate amount of purified water and soak for 10 hours, stir well until it is completely swollen into a uniform gel-like polymer, and then add sorbic acid 0.5 parts of potassium phosphate, 0.2 parts of methylparaben and 3 parts of miconazole nitrate were stirred and mixed evenly; b: heating 6.5 parts of glycerin, 4.5 parts of liquid paraffin and 2 parts of glyceryl behenate to melt, and fully stirred to obtain Uniform oil phase; c: quickly add B to A while hot, stir to mix the two phases thoroughly to obtain a uniform turbid liquid, add purified water while stirring...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to the technical field of antifungal drugs and specifically to a sustained-release miconazole nitrate gel and a preparation method thereof. The sustained-release miconazole nitrate gel is prepared from the following ingredients in parts by weight: 2-5 parts of miconazole nitrate, 0.1-1 part of polycarbophil, 0.5-2 parts of carbopol 934P, 5-7 parts of glycerin, 4-5 parts of liquid paraffin, 0.1-1 part of potassium sorbate, 0.1-1 part of methylparaben, 1-3 parts of glycerin behenate, and purified water added till 100 parts. The sustained-release miconazole nitrate gel of the invention is based on bioadhensive materials polycarbophil and carbopol as matrices for the gel, such that the local resistance time can be prolonged; the gel can be rapidly released to an effective dose and can be slowly released for continuous 12 h at the effective dose, and has the advantages of hydrophily, no greasiness, and the like.

Description

technical field [0001] The invention relates to the technical field of antifungal drugs, in particular to a miconazole nitrate sustained-release gel and a preparation method thereof. Background technique [0002] Miconazole nitrate is an antifungal drug. This product can inhibit the growth of most fungi at a certain concentration. Blastomyces and Histoplasma are highly sensitive to it. Cryptococcus, Candida, Coccidioides, etc. It is also sensitive to this product. Gynecology is mainly used for vaginal infections caused by Candida and repeated infections caused by Gram-positive bacteria. The traditional vaginal dosage forms of miconazole nitrate, such as ointment and suppository, have a relatively large oil-water partition coefficient and weak ability to penetrate the skin and mucous membranes; ordinary gel dosage forms have a short residence time at the site of action and require multiple administrations within a day, which not only affects the Curative effect, also brings ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K9/06A61K31/4174A61K47/32A61P31/10A61P15/02
CPCA61K9/06A61K9/0002A61K9/0034A61K31/4174A61K47/32
Inventor 邢树礼姜宏李保院高新富高培民
Owner 滨州医学院附属医院
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com