Chinese and western combine compound uterus perfusate for treating cow endometritis

Abstract

The invention discloses compound intrauterine infusion liquid of western medicine and Chinese traditional medicine for treating cow endometritis and a preparation method thereof, the infusion liquid takes oxytetracycline, motherwort herb, peach seed, Chinese angelica, Szechuan lovage rhizome, membranous milkvetch root, liquoric root and a plurality of excipients as raw materials and is prepared by decoction, filtration, concentration, pumping filtration, concentration, spray drying, micro-powderization of oxytetracycline, homogenization and other processes; the infusion liquid has the advantages that firstly, the raw materials constitute the safe, effective and comprehensive infusion liquid which can not only realize the rapid anti-inflammation, but can also restore the functions of the body with the diseases after the inflammation, promote the pregnancy and treat the infertility; secondly, the infusion liquid adopts the formulation of microparticle suspension, the unit solvent drug-loaded amount is great, the drug delivery volume is small, the chemical properties of the drug microparticles are stable, the bioadhesion is stronger, the drug release is sustained, the infusion liquid can be adhered on the cow uterine endometrium for a long time, thus directly stimulating a uterine receptor, ensuring the drug to be fully absorbed as well as better and rapidly playing the roles.

Description

technical field [0001] The invention relates to a Chinese and western medicine compound uterine perfusate for treating cow endometritis, and also relates to a preparation method of the perfusate. Background technique [0002] Dairy cow endometritis is a common disease in dairy cows, which not only affects normal physiological functions, but also causes infertility, and in severe cases, it will cause lifelong infertility due to stimulation of other reproductive system diseases. According to incomplete statistics, nearly 2 / 3 of the multiparous dairy cows in China suffer from different degrees of endometritis, which has caused serious hidden dangers to the development of the dairy industry. [0003] At present, the treatment of endometritis in dairy cows at home and abroad is mostly based on antibiotics. However, according to the introduction of "Dairy Cow Diseases" written by Robert, S.J. published by China Agricultural University in 2000, the treatment of cows with endometrit...

AI Technical Summary

Problems solved by technology

Although traditional Chinese medicine has a definite curative effect on the treatment of cow endometritis, especially for the restoration of uterine function after anti-inflammation, and the promotion of pregnancy in cows, and it also has the advantages of no drug resistance, low residue, and small side effects, but pure Chinese medicine should be used for treatment The disadvantage is that the course of treatment is too long and the effect is slow

[0005] Comprehensive analysis shows that the best way to treat dairy cow endometritis is to use Western medicine to perfuse the cow's uterus, so that the drug can directly reach the lesion, achieve rapid anti-inflammation, and reduce the drug concentration in the blood. The traditional Chinese medicine ingredients in the medicine can be used for effective repair. There is no literature report on the compound uterine perfusion fluid combining Chinese and Western medicine.