58 results about "Uterine endometrium" patented technology

The invention relates to the technical field of medical care information processing, and discloses a traditional Chinese medicine prescription efficacy evaluation system for treating intrauterine adhesion, comprising: a data preprocessing module for acquiring endometrial dynamic response gray time sequence characteristic data before and after a subject takes a prescription; the phase analysis module is used for determining a phase deviation distribution coefficient according to the phase angle distribution of the gray scale data of the reference pixel and the response pixel; the frequency domain inversion module is used for constructing an energy transfer gain spectrum by calculating a power ratio and identifying a characteristic resonant frequency; the evaluation index output module is used for generating an evaluation index for evaluating the viscoelasticity improvement degree of the endometrial tissue according to the deviation value of the characteristic resonant frequency in combination with the variation of the phase deviation distribution coefficient. And the quantitative accuracy of evaluation is improved.

The invention relates to the technical field of medical artificial intelligence monitoring, and discloses an intelligent monitoring method and system for a perfusion curative effect of a thin endometrial rich microplate. The method comprises the following steps: standardizing and fusing multi-source monitoring data, constructing a derivative feature set reflecting a treatment coordination rule through cross-cycle feature derivation, and establishing a curative effect behavior coding library according to the derivative feature set. After the real-time data is subjected to standardization processing, frame-by-frame mode matching and similarity calculation are carried out on the real-time data and a coding library, a corresponding analysis path is activated according to a result, and a curative effect behavior fragment with a timestamp is generated. The segments are associated and aggregated to form a complete curative effect event chain, key turning points are marked, and finally a structured monitoring report and a decision signal are generated through multi-dimensional influence evaluation. According to the invention, the conversion from static parameter judgment to dynamic curative effect behavior intelligent analysis is realized, and the continuity, accuracy and early warning capability of treatment process monitoring are improved.

This invention discloses the application of ethinylestradiol and drospirenone in the preparation of drugs for treating post-traumatic stress disorder (PTSD). Ethinylestradiol, as an estrogen receptor agonist, regulates the hypothalamic-pituitary-gonadal axis and is used to treat female hypogonadism, menopausal syndrome, and advanced breast cancer, often in combination with progestins as oral contraceptives. The use of drospirenone and ethinylestradiol tablets (II) after induced abortion can shorten vaginal bleeding time, promote endometrial repair, and reduce the incidence of postoperative complications and repeat miscarriages. This invention has found that ethinylestradiol and drospirenone can reverse the abnormal decrease in hormones and neurosteroids caused by PTSD after spontaneous abortion, particularly the abnormal decrease in serotonin and tetrahydroprogesterone.

LNPs can penetrate uterine mucosa to deliver therapeutic or prophylactic agents such as functional nucleic acids to the endometrium. Targeting of the LNPs using ligands expressed at particular times in an endometrial cycle ensures that the LNPs penetrate and release the mRNA primarily to the tissue associated with the peak time period for implantation, thereby providing a means to address infertility, as well as for treatment of other disorders such as cancer.

The invention relates to the technical field of uterus image segmentation, in particular to a woman uterus disease auxiliary diagnosis and evaluation system based on magnetic resonance imaging. After a uterus image of a patient is obtained and a uterine cavity area is positioned, clustering clusters are divided according to pixel gray values by using a clustering algorithm to correspond to different uterus areas. And generating an endometrial region descriptor and screening out an endometrial region by combining the pixel number distribution of each region, the gray features and the shape difference between the endometrial region descriptor and the uterine cavity. Performing gray scale segmentation on the region to extract a high-signal region, and calculating an internal descriptor according to internal edge distribution and morphological characteristics of the high-signal region; meanwhile, an external descriptor is generated based on edge pixel neighborhood gray scale difference. And finally fusing internal and external descriptors to realize auxiliary diagnosis of uterine diseases. According to the method, the uterus image with obvious uterine cancer staging development tendency can be screened out, and a more accurate diagnosis effect is provided for related personnel.

This invention discloses an endometrial stem cell preparation and its application for cervical hypertrophy and cuticle repair, belonging to the field of stem cell technology. The endometrial stem cell preparation includes a stem cell gel carrier, endometrial stem cells, auxiliary repair peptides, and a survival enhancer. In the endometrial stem cell preparation, the stem cell gel carrier, endometrial stem cells, auxiliary repair peptides, and survival enhancer work synergistically to improve the survival rate of endometrial stem cells in vivo. The auxiliary repair peptides can activate the MAPK / ERK pathway of endometrial stem cells, and the anti-inflammatory mimic peptides in the survival enhancer can inhibit the stress silencing of endometrial stem cells, thereby ensuring the secretory function of endometrial stem cells. Furthermore, the three-dimensional porous structure of the stem cell gel carrier enhances the targeted repair ability of endometrial stem cells and enhances the homing and colonization of endometrial stem cells to cervical lesions.

The invention provides a uterine cavity treatment device, and belongs to the technical field of uterine cavity postoperative continuous treatment devices. The treatment device comprises a uterine cavity support and a conveying system, the uterine cavity support comprises a supporting framework and a medicine carrying covering film, a main body of the supporting framework is of a big-end-up three-dimensional cage-shaped structure, angle-shaped protrusions are symmetrically arranged on the left side and the right side of the far end of the supporting framework, and the angle-shaped protrusions obliquely extend upwards with the center of the uterine cavity support as the reference; an arc-shaped structure is formed, so that the whole shape of the supporting skeleton is matched with the uterus shape after the supporting skeleton is automatically expanded; the medicine carrying covering film is at least arranged on the outer side of the supporting framework; a hormone sustained-release drug is arranged in the drug-loading covering membrane and is used for promoting repair of endometrium; the conveying system is used for loading the uterine cavity stent in a contracted state and conveying the uterine cavity stent to a target position to complete release; the technical problem that in the prior art, the effect of treating intrauterine adhesion after an intrauterine operation is poor is mainly solved.

The application provides a trophoblast organ-on-chip system for simulating a maternal-fetal interface of a systemic lupus erythematosus model based on an organ chip and a construction method thereof, the system taking an organ chip as a carrier and comprising three core parts of a trophoblast organ, an endometrial chip and an SLE disease model. The application completes separation culture and characterization of the trophoblast organ, multi-cell co-culture construction and characterization of the endometrial chip, and then constructs a pathological model, and the three parts cooperatively form a three-dimensional maternal-fetal interface. The system can clearly observe the dynamic process of the trophoblast organ invading the endometrial chip, can detect the continuous secretion of hCG and SLE-related inflammatory factors, and breaks through the defects of the prior art model, such as low authenticity, inability to dynamically observe, single detection dimension and lack of standardization, and has both physiological and pathological adhesion and experimental repeatability, can multi-dimensionally characterize the cell phenotype and function of the maternal-fetal interface, and provides an in-vitro research platform for the pathological mechanism research of the SLE pregnancy-related abnormal maternal-fetal interface.

The present application relates to the field of traditional Chinese medicine, and specifically relates to a kind of external use traditional Chinese medicine composition for treating thin endometrium, which is composed of the following raw medicinal materials: cinnamon 250-300g, fennel 250-300g, Corydalis 250-480g, Cnidium 250-400g, safflower 250-300g, Evodia 150-200g, mugwort leaf 250-300g, and ginger juice 500-600ml.The external use combined medicine of the present application can obviously improve the symptoms of dysmenorrhea, little menstrual flow, dark red menstrual color, and more menstrual blood clots, thicken the endometrial thickness during ovulation, and improve the clinical pregnancy rate of patients with thin endometrium.The external use traditional Chinese medicine is absorbed through skin, does not burden liver and kidney functions, achieves the purposes of warming meridians, activating blood and resolving stasis through the action of acupoint meridian, has little side effects, and is convenient for promotion.

The application provides an injectable hydrogel for endometrial repair and / or prevention of adhesion of uterine cavity and a preparation method and application thereof, and belongs to the technical field of biomedical materials. The injectable hydrogel is composed of a base gel and a decellularized matrix distributed in the base gel; the base gel is composed of a cross-linked carboxymethyl chitosan gel and a carbomer gel; the base gel has an interpenetrating or semi-interpenetrating double network structure; and the cross-linked carboxymethyl chitosan gel is a chemical cross-linked carboxymethyl chitosan gel. In the application, the injectable hydrogel forms a base gel with an interpenetrating or semi-interpenetrating double network structure by using a cross-linked carboxymethyl chitosan gel and a carbomer gel, and is compounded with a decellularized matrix, so that the injectable hydrogel has high elasticity and high adhesion, can effectively prevent adhesion and repair damaged tissues, has a long action time, and has good biocompatibility.

The application discloses a preparation method of a 3D model of a maternal-fetal interface constructed by an endometrial organoid in vitro, and the method comprises the following steps: establishing a primary endometrial epithelial organoid and an endometrial stromal cell line in vitro; improving an extracellular matrix for assembling endometrial gland-like organoids and stromal cells; the constructed endometrial organoid model comprises gland cells and stromal cells; the endometrial organoid model is cultured by using a gas-liquid interface, so that the endometrial organoid model has a cavity epithelium and a gland structure; the endometrial organoid model simulates a menstrual cycle of the endometrium and performs function identification. The endometrial organoid model has the cavity epithelium and the gland epithelium for the first time, the tissue structure, the cell composition, the hormone-induced change, the gene expression characteristics of the organoid are similar to those in the body, and the organoid can reproduce the receptivity genes and the dynamicity of cilia which are necessary for embryo implantation in the body; the organoid can be used as a model for studying embryo implantation regulation, endometrial diseases and regeneration mechanisms.

1. The name of the design product: ultrasonic transducer. 2. The use of the design product: used for converting input electric energy into ultrasonic wave and emitting ultrasonic energy as one of the components of ultrasonic probe, cooperating with ultrasonic probe to realize ultrasonic examination, such as promoting postpartum lochia discharge, restoring uterus and its appendages to prepartum state, postabortion uterine involution, relieving pain including postpartum pain and dysmenorrhea, repairing endometrium and repairing scar. 3. The design points of the design product: in shape. 4. The picture or photo best indicating the design points: perspective view 1.

The present invention relates to a composition for endometrial regeneration containing a uterus-derived decellularized extracellular matrix (UdECM) and a manufacturing method therefor. Characterized by containing uterus-derived decellularized extracellular matrix (UdECM), the composition can exhibit the effect of enhancing the regeneration, receptivity, and implantation capabilities of the endometrium.

The present application relates to the technical field of endoscopes. Disclosed are a drug release device and an endoscopic assembly. The drug release device comprises a first tube, a balloon and a light-emitting structure. The balloon is configured as a light-transmissive and expandable structure, and a structural layer of the balloon encloses an inner cavity, such that the inner cavity and the distal end of the first tube are sealed and are in communication with each other. Moreover, the first tube extends into the inner cavity, and then the light-emitting structure is provided in the balloon. Light emitted by the light-emitting structure and a photosensitive cross-linked drug composite layer located outside the structural layer are used to induce a cross-linking reaction. After the balloon is inserted into the uterus, a liquid can be injected into the balloon through the first tube so as to expand the balloon, and the expanded balloon can abut against the endometrium. After the light-emitting structure emits light, the photosensitive cross-linked drug composite layer can adhere to the surface of the endometrium, thereby enabling a drug contained in the photosensitive cross-linked drug composite layer to fully and tightly attach to the endometrium for the continuous treatment or repair of the endometrium.

The application provides an amniotic membrane biological composite material and a preparation method and application thereof, and the composite material comprises amniotic membrane microcarriers, mesenchymal stem cells and a polypeptide hydrogel, wherein the amniotic membrane microcarriers are 3D load type three-dimensional structures, the amniotic membrane microcarriers are loaded with the mesenchymal stem cells, and the mesenchymal stem cells are mixed and cultured with a polypeptide solution at a ratio of 1:2-1:4 to obtain a mesenchymal stem cell-amniotic membrane microcarrier-polypeptide hydrogel biological composite material. The combination of the amniotic membrane microcarriers and the hydrogel provides three-dimensional support for stem cells, perfusion into the uterine cavity can make the cells survive for a long time, meanwhile, the microcarriers and the hydrogel have a slow-release effect on the excretion of the stem cells, and are more conducive to promoting the repair effect of the mesenchymal stem cells, and can be used for endometrial repair.

The present invention relates to a composition for endometrial regeneration containing a uterus-derived decellularized extracellular matrix (UdECM) and a manufacturing method therefor. Characterized by containing uterus-derived decellularized extracellular matrix (UdECM), the composition can exhibit the effect of enhancing the regeneration, receptivity, and implantation capabilities of the endometrium.

An apparatus configured to facilitate delivery of an embryo to an implantation site on an endometrium of a patient is provided. The apparatus comprises one or more walls defining a cavity, the walls comprising a rim configured for adhering to the endometrium and defining an opening to the cavity. The walls comprise one or more throughgoing apertures, each sized to allow passage therethrough of intrauterine environmental molecules, and to prevent passage therethrough of a blastocyst. The material of the walls is configured to degrade in the intrauterine environment within a predetermined range of time.

The invention discloses a sampler for collecting endometrial cells or tissue samples and a use method of the sampler, and belongs to the technical field of medical instruments, and the sampler comprises a flexible catheter and a deformable inner core guide wire; the inner core guide wire is made of hyperelastic shape memory alloy, the inner core guide wire is composed of a near-end rod body and a far-end self-adaptive brush head, and when the far end of the inner core guide wire is pushed out of the flexible catheter, the self-adaptive brush head is automatically unfolded to form an inverted triangular frame; a plurality of flexible bristles with Shore A hardness of 10A-30A are distributed on the self-adaptive brush head in a three-dimensional gradient manner; the invention further provides an application method. According to the invention, through the combination of the'automatically unfolded inverted triangular brush head 'and the'three-dimensional gradient distributed soft bristles', the shape self-adaption and full-coverage sampling of the uterine fundus and the uterine horn of the uterine cavity are realized, and the omission ratio is obviously reduced; the ultra-thin flexible catheter is combined with the extremely-soft bristles, so that the full-path noninvasive and safe operation from the hymen to the endometrium is ensured, and the applicable crowd is expanded.

The utility model relates to the technical field of medical instruments, and provides an endometrium hot steam ablation uterine cavity pressure relief device and steam ablation equipment, the pressure relief device comprises a pressure relief valve body, a valve assembly and a return elastic piece, and the pressure relief valve body is provided with a pressure relief valve cavity, a pressure relief inlet and a pressure relief outlet; the valve assembly can move relative to the pressure relief valve cavity so as to be switched between a sealing position and a pressure relief position, the return elastic piece is arranged between the valve assembly and the pressure relief valve body, and the return elastic piece is used for driving the valve assembly to return to the sealing position. When the pressure is larger than the set pressure of the pressure relief device, the valve assembly moves to the pressure relief position, the valve assembly is separated from the pressure relief inlet, and the return elastic piece deforms, so that the pressure relief inlet is communicated with the pressure relief outlet through the pressure relief valve cavity to start the pressure relief work, and the pressure in the uterine cavity is in a normal pressure range; therefore, the risk of tissue injury caused by steam invading the fallopian tube is avoided, and the safety of the steam ablation equipment is greatly improved.

The present application relates to the technical field of medical devices, in particular to a device for improving the implantation of fertilized eggs during pregnancy, comprising a handle, a connecting arm arranged on the handle, a sleeve arranged on the connecting arm, the connecting arm comprising a rigid section, a first curved section arranged at the distal end of the rigid section, and a second curved section arranged at the distal end of the first curved section, the second curved section being controlled to curl through a second trigger mechanism, and then the first curved section being controlled to bend through a first trigger mechanism, the distal end part of the sleeve in the shape of a U being used to scratch the endometrium, thus increasing the scraping area, and meeting the requirement of scratching only the functional layer of the endometrium without touching the basal layer, avoiding the problem of deep groove-like damage on the endometrium caused by the thin end part during scratching, and the second curved section being controlled to curl reciprocally through the second trigger mechanism, so as to scratch the narrow uterine horn area with the thin end part, which is very suitable for improving the implantation rate of fertilized eggs during pregnancy.

The invention discloses a co-culture model based on endometrial stromal cell organoid and follicle organoid as well as a construction method and application of the co-culture model, and belongs to the technical field of reproductive medicine and cell engineering. The invention discloses a construction method of a co-culture model based on an endometrial stromal cell organ and a follicle organ. The construction method comprises a culture method of the follicle organ, a culture method of the endometrial stromal cell organ and co-culture of the follicle organ and the endometrial stromal cell organ. The 3D follicle-like organ and endometrial stromal cell-like organ co-culture system provided by the invention can reproduce in-vivo physiological conditions more truly, can be used for exploring a deciduous molecular mechanism, and also has the potential of constructing a high-throughput detection platform for drugs and environmental toxicants.

The invention provides an endometrial receptivity evaluation method, device and equipment, a medium and a program product. The method comprises the following steps: acquiring a fresh embryo transplantation type, clinical data of a patient and a uterus longitudinal section ultrasonic image of an ovum taking day; performing endometrial segmentation on the ultrasonic image to obtain an endometrial region, and determining a peripheral region based on the endometrial region and a transplantation type; extracting radiomics characteristics of the endometrial region and the peripheral region, and extracting clinical characteristics of the clinical data; and inputting the image omics characteristics and the clinical characteristics into an endometrial receptivity multi-modal evaluation model corresponding to the transplantation type to obtain the pregnancy probability output by the multi-modal evaluation model after the fresh embryo transplantation in the current period. According to the method, the device, the equipment, the medium and the program product provided by the invention, real-time analysis is carried out in combination with an artificial intelligence technology, and an evaluation result of the fresh embryo transplantation period can be provided in a short time.

The invention provides a gynecological ultrasonic image analysis method and system, and the method comprises the steps: obtaining an anatomical structure feature set including endometrial boundary features, ovarian follicle distribution features and uterine muscular layer texture features through a standardized ultrasonic image, and generating a structured segmentation map of a key anatomical structure of a target subject based on the anatomical structure feature set; performing dynamic parameter quantization on the structured segmentation map to obtain physiological dynamic parameters of the target subject, and further obtaining a functional state evolution curve of the reproductive organ of the target subject; performing feature level fusion on the structured segmentation map and the functional state evolution curve of the reproductive organ, and determining a multi-dimensional evaluation matrix of the reproductive health state of the target subject according to a fusion result; and generating a comprehensive diagnosis report of the target subject according to the multi-dimensional evaluation matrix, and using the comprehensive diagnosis report for auxiliary diagnosis of clinicians. By means of the scheme, automatic early screening of gynecological diseases can be achieved based on combined dynamic analysis of the anatomical structure and the physiological function.

The preparation method comprises the following steps: by taking 3, 4-dihydroxyphenylacetic acid and 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide as raw materials, carrying out pre-activation reaction in an organic solvent, and adding 1-hydroxybenzotriazole to carry out activation reaction, so as to obtain a reaction product; slowly adding the reaction product into a protamine buffer solution, carrying out amidation coupling reaction, and purifying and drying to obtain the protamine-DOPAC conjugate. According to the protamine-DOPAC conjugate, the residence time of the exosome in a uterine cavity can be prolonged, and the action efficiency of the exosome in an endometrium can be improved. The protamine-DOPAC conjugate provided by the invention has an application prospect in the drug delivery direction.

The utility model relates to a collector applied to endometrial cells and tissues. The collector comprises a catheter, an elastic skeleton, a movable strip, a seat body and a flow channel structure, a medical worker guides the insertion end of the catheter into the uterine cavity of a patient, then the elastic framework at the connecting end is gradually pushed out of the insertion end by pushing the operation end of the movable strip, the elastic framework is outwards unfolded under the action of self elasticity, and the medical worker can drive the movable strip and the elastic framework to synchronously rotate by rotating the operation end; and the cells and tissues of the endometrium can be scraped by the outline of the elastic skeleton, so that the cells and tissues fall into the uterine cavity. After the operation of scraping the cells and the tissues of the endometrium is completed, a medical worker can connect an upper negative pressure device at the collection interface on the seat body, and the scraped cells and the tissues in the uterine cavity are fully extracted through the flow channel structure, so that the collection of the cells and the tissues of the endometrium is completed. Compared with the prior art, the collector has the advantage of high collection efficiency.

A single, handheld medical device for performing an endometrial abrasion and / or HSG procedure is disclosed. The preferred embodiment comprises a body that includes a handle integrally connected to an arm with an articulating member at its distal end. The handle comprises a means for storing and pumping a fluid into the uterus so that ultrasound or x-ray can be used to determine the location of the articulating member within the uterus. The arm further comprises a shielding device that is operable to slidably engage the arm of the device and the shield and the arm are configured to cover and sealingly engage the external os of the cervix to prevent reflux during use. Optional viewing means are disclosed, including an imaging screen mountably attached to the device and in communication with a scope disposed within the arm.

The invention provides a median sagittal ultrasound image-based uterus model generation method, system and device, and the method comprises the steps: obtaining an initial uterus structure contour outputted by an ultrasound image segmentation model, and the initial uterus structure contour comprises an endometrial region; converting the initial uterus structure contour into a geometric contour, and performing closed repair on the geometric contour to obtain an initial polygon; performing morphological preprocessing on the initial polygon to obtain a smooth structure contour; fitting the central axis of the uterine cavity according to the outline of the endometrial area, and determining the dissection orientation of the uterus; when the smooth structure contour lacks a cervical structure, generating a synthesized cervical contour based on the geometrical relationship between the central axis and the foot side of the uterine contour; carrying out normalization processing on a complete uterus contour containing the synthesized cervix contour and the endometrium contour so as to map to a preset canvas; and according to a preset drawing rule, generating a uterus median sagittal pattern graph on the canvas.

The present disclosure relates to a prediction method, a prediction model based on transcriptome analysis for predicting the window of implantation (WOI) of the endometrium, and its use in patients with recurrent implantation failure (RIF), in particular in patients with endometrium-derived recurrent implantation failure. The present disclosure also relates to a device or system for said method and said use.

The application discloses a device and a use method for detecting endometrial peristaltic wave, which comprises a main stem, a branch stem, an electrode array and a drug sustained-release array, the main stem is provided with the branch stem, the main stem and the branch stem are both provided with the electrode array, and the main stem is further provided with the drug sustained-release array. The application belongs to the technical field of measuring devices, and aims to solve the problem of inaccurate measurement of endometrial peristaltic frequency in the prior art. The technical effect is that the device realizes the measurement of endometrial peristaltic wave and the treatment of endometrium through the arrangement of the electrode array and the drug sustained-release array.

The application belongs to the technical field of medical devices, and particularly relates to a delivery device of a degradable biological membrane for promoting endometrial regeneration, which comprises a sleeve, a push rod, a movable support and a control switch, the push rod is slidingly arranged in the hollow sleeve, the movable support and the control switch are respectively arranged at two ends of the push rod, the control switch is used for driving the movable support to open or close, when the push rod drives the movable support to be accommodated into the sleeve, the movable support is in a closed state, and when the push rod drives the movable support to extend out of the sleeve, the control switch can drive the movable support to open. Advantageous effects: the delivery device is convenient for delivering the uterine repair membrane into the uterine cavity and effectively protecting the uterine repair membrane, the uterine repair membrane is conveniently spread in the uterine cavity, and the uterine repair membrane is uniformly attached to the uterine wall by using water pressure.