161 results about "Uterine endometrium" patented technology

Systems and methods for enhancing visualization and documentation of fibroid quantity, size, and location with respect to a uterus and endometrium in ultrasound imaging are provided. The method includes receiving, by at least one processor, an ultrasound volume including ultrasound image data of a region of interest that includes a uterus. The method includes automatically segmenting, by the at least one processor, the uterus and an endometrium in the ultrasound volume. The method includes segmenting one or more fibroids in the ultrasound image data. The method includes generating a classification of each of the one or more fibroids based on a location of each of the one or more fibroids with respect to the endometrium and the uterus. The method includes causing, by the at least one processor, a display system to present at least one image identifying the segmented uterus, endometrium, and one or more fibroids.

A pharmaceutical composition according to an aspect can be applied to the prevention, treatment or the like of endometrial damage, Asherman's syndrome, or complications thereof by: reducing the level of collagen accumulation in the endometrium; increasing the expression level of VEGF; increasing the expression level of Ki67; increasing the expression level of Itgb3; increasing the expression level of Spp1; increasing the number of implantation sites; decreasing the expression levels of fibrosis-related factors; decreasing the expression levels of metabolism-related factors; increasing ATP production; and regulating the expression levels of mitochondrial function-related factors.

The invention discloses a functional polypeptide for promoting repair of endometrial stem cells to clitoris sensitive nerves and application, and belongs to the technical field of stem cell repair, the functional polypeptide is used for modifying the endometrial stem cells and Schwann cells through the functional polypeptide, and the clitoris sensitive nerves are repaired in a local slow-release gel delivery mode. The functional polypeptide can activate Laminin expression and regulate and control ECM degradation balance, so that collagen deposition in scar tissues is reduced; in addition, the functional polypeptide can effectively inhibit HOXA1 expression, enhance the axon extension capacity and strengthen the axon microtubulin polymerization capacity of the nerve injury part, and the nerve repair efficiency and the function recovery quality are remarkably improved.

The invention relates to the technical field of medical gel, and particularly discloses a sustained-release gel preparation for endometrial repair and a preparation method of the sustained-release gel preparation. Keratinocyte factor sustained-release microspheres containing keratinocyte factor-glucan particles and lactic acid-glycolic acid copolymer shells are constructed around keratinocyte factors, and the keratinocyte factor sustained-release microspheres are loaded by hyaluronic acid hydrogel containing polylysine, collagen and silk fibroin to form the sustained-release gel preparation for endometrial repair. The sustained-release gel preparation has the effect of promoting proliferation of human endometrial cells, can repair endometrial injury, promote injury healing and prevent uterine cavity adhesion, and has important significance in treating endometrial injury and improving physical and psychological health of women.

The invention relates to the technical field of diagnosis of gynecological and obstetrical diseases, in particular to an endometrial disease onset risk prediction method and system. By combining multiple groups of indexes and image group feature data, the endometrium can be effectively evaluated, score data reflecting the tumor state of the endometrial disease can be obtained, and the incidence probability and the staging result degree of the endometrial disease can be more intuitively determined through the score data. Therefore, the overall automatic prediction of the endometrial disease is realized.

A system for treating uterine tissue having a seal assembly configured for positioning in a patient's cervical canal and uterine cavity; an expandable distal balloon portion; an expandable elongate medial balloon portion configured for movement between a first transversely expanded shape for engaging a cervical canal and a second transversely non-expanded shape for trans-cervical insertion; and a fluid source in communication with distal balloon portion and medial balloon portion for expansion of said balloon portions.

The invention relates to the technical field of biology, and particularly discloses a construction method and application of an endometrial epithelium organ fibrosis model. According to the method, human endometrial epithelial cells are extracted, and an endometrial epithelial organ is established by adopting a Matrigel three-dimensional culture system. Afterwards, the organoid is induced to form endometrial phenotypes in different physiological cycles through hormone stimulation, and a ferroptosis inducer FIN56 is added in the culture process to induce fibrosis. The expression of GPX4, Fibronectin and p-Smad2 / 3 is detected through Western blot and immunofluorescence, and the successful construction of the fibrosis model is verified. The invention provides an in-vitro model capable of simulating endometrial fibrosis pathological characteristics of a patient with PCOS (polycystic ovarian syndrome), the in-vitro model can be used for mechanism research and drug screening of PCOS-related endometrial lesions, and a new research tool and an intervention strategy are provided for treatment of PCOS endometrial fibrosis.

Methods for enhancing the visualization of a myoma relative to the uterus and endometrium in ultrasound imaging are provided. The method includes receiving, by at least one processor, an ultrasound volume including ultrasound image data of a region of interest, automatically segmenting the uterus and endometrium in the ultrasound volume, segmenting one or more myomas in the ultrasound image data, and outputting the one or more myomas. A classification of each of the one or more myomas is generated based on a position of each of the one or more myomas relative to the endometrium and the uterus such that the display system presents at least one image identifying the segmented uterus, endometrium, and one or more myomas. The application also provides a system for enhancing the visualization of a myoma relative to the uterus and endometrium during ultrasound imaging.

The invention relates to a lightweight yolov8-based endometritis classification and identification method and system, and the method comprises the steps: determining classified target historical hysteroscope image data, and enabling classification labels to comprise a normal classification group indicating normal endometrium and a lesion classification group indicating the existence of endometritis; dividing the target historical hysteroscope image data according to a preset distribution proportion to obtain training data and verification data; training data and verification data are input into a yolov8 classification model, in the training process, model lightweight processing is carried out based on weight importance pruning, quantification and knowledge distillation technologies, and feature weighting and selection based on an attention mechanism are carried out on target area features detected by yolov8 and related to endometrium and pre-acquired auxiliary modal features, so that the model weight is reduced; key feature information is extracted; and inputting real-time hysteroscope image data into the trained yov8 classification model to obtain an endometrial inflammation classification result for auxiliary diagnosis.

The invention relates to a pharmaceutical composition for treating uterine adhesion and application thereof. The kidney reinforcing and miscarriage preventing pills are used for improving endometrial blood perfusion and increasing the endometrial thickness, the kidney reinforcing and miscarriage preventing pills, aspirin and estrogen play a synergistic treatment role, the postoperative re-adhesion rate is remarkably reduced through combined treatment, and the fertility prognosis of a patient is improved; and the molecular mechanism of a TGF-beta1 pathway and EMT is deeply researched, and by inhibiting excessive activation of the TGF-beta1 signaling pathway, reducing endometrial fibrosis, regulating an epithelial-mesenchymal transition (EMT) process and promoting regeneration of endometrial epithelial cells, endometrial repair is further promoted, multi-target treatment is realized, and the treatment effect is remarkable. A brand-new and efficient treatment scheme is provided for treatment of intrauterine adhesion, an individualized treatment scheme can be formulated according to the specific conditions of patients, the treatment accuracy and effectiveness are improved, and important clinical significance and application value are achieved.

The invention belongs to the technical field of medical model construction, and particularly relates to a construction method of a severe endometrial injury mouse model ineffective in MSCs treatment. The method specifically comprises the following steps: S1, selecting a female mouse to adapt to the environment for 2-3 days; s2, after the mouse adapts to the environment, anesthetizing the mouse on the 0th day, performing laparotomy to physically scrape the inner uterine wall of the mouse, and then performing injury induction and suturing on the inner uterine wall by using an LPS (Lipopolysaccharide) solution; s3, repeating the step S2 on the third day, and performing laparotomy, curettage, LPS induction and suture on the mouse; s4, preliminarily evaluating the severe endometrial injury condition of the mouse on the fifth day; s5, injecting MSCs into the uterus of the mouse with the severe endometrial injury to treat the endometrial injury; and S6, on the eighth day, collecting a uterus sample to evaluate the repair capability of the MSCs, and screening to obtain the severe endometrial injury mouse model ineffective in MSCs treatment. Through a mode of carrying out physical curettage and lipopolysaccharide induction on the uterus through twice laparotomy, severe IUA patients ineffective in clinical MSCs treatment are better simulated.

The invention discloses a medicine release instrument and an endoscope assembly, and relates to the technical field of endoscopes. The drug release instrument comprises a first tube body, a balloon and a light-emitting structure. The balloon is arranged to be of a light-transmitting and expandable structure, the inner cavity is defined by the structural layer of the balloon, the inner cavity and the far end of the first tube body are arranged in a sealed mode and communicate with each other, meanwhile, the first tube body extends into the inner cavity, and then the light-emitting structure is arranged in the balloon; light emitted by the light-emitting structure and the photosensitive cross-linked medicine composite layer located outside the structural layer are utilized to induce a cross-linking reaction, after the balloon stretches into the uterus, liquid can be injected into the balloon through the first tube body so that the balloon can be expanded, the balloon can abut against the endometrium after being expanded, and after the light-emitting structure emits the light, the light-emitting structure can emit the light. The photosensitive cross-linked drug composite layer can be adhered to the surface of the endometrium, so that the drug in the photosensitive cross-linked drug composite layer can be fully and tightly adhered to the endometrium, and the endometrium can be continuously treated or repaired.

The invention relates to the technical field of medical care information processing, and discloses a traditional Chinese medicine prescription efficacy evaluation system for treating intrauterine adhesion, comprising: a data preprocessing module for acquiring endometrial dynamic response gray time sequence characteristic data before and after a subject takes a prescription; the phase analysis module is used for determining a phase deviation distribution coefficient according to the phase angle distribution of the gray scale data of the reference pixel and the response pixel; the frequency domain inversion module is used for constructing an energy transfer gain spectrum by calculating a power ratio and identifying a characteristic resonant frequency; the evaluation index output module is used for generating an evaluation index for evaluating the viscoelasticity improvement degree of the endometrial tissue according to the deviation value of the characteristic resonant frequency in combination with the variation of the phase deviation distribution coefficient. And the quantitative accuracy of evaluation is improved.

A peristaltic wave parameter measurement method and ultrasonic measurement system, the method comprising: transmitting a first ultrasonic wave to the endometrium of a measured object, receiving an ultrasonic echo returned by the endometrium, to obtain a first ultrasonic echo signal; processing the first ultrasonic echo signal to obtain a peristaltic parameter in a target area of ​​the endometrium that changes with time; obtaining a transmission time of the peristaltic wave in the target area based on the peristaltic parameter in the target area that changes with time; and outputting the transmission time. The peristaltic wave parameter measurement method and ultrasonic measurement system quantify and output the transmission time of the peristaltic wave as a new peristaltic wave-related parameter, providing users with an objective measurement tool for peristaltic waves.

The invention relates to the technical field of medical artificial intelligence monitoring, and discloses an intelligent monitoring method and system for a perfusion curative effect of a thin endometrial rich microplate. The method comprises the following steps: standardizing and fusing multi-source monitoring data, constructing a derivative feature set reflecting a treatment coordination rule through cross-cycle feature derivation, and establishing a curative effect behavior coding library according to the derivative feature set. After the real-time data is subjected to standardization processing, frame-by-frame mode matching and similarity calculation are carried out on the real-time data and a coding library, a corresponding analysis path is activated according to a result, and a curative effect behavior fragment with a timestamp is generated. The segments are associated and aggregated to form a complete curative effect event chain, key turning points are marked, and finally a structured monitoring report and a decision signal are generated through multi-dimensional influence evaluation. According to the invention, the conversion from static parameter judgment to dynamic curative effect behavior intelligent analysis is realized, and the continuity, accuracy and early warning capability of treatment process monitoring are improved.

An ultrasonic imaging method and device and a computer-readable storage medium are provided. The ultrasonic imaging method includes: ultrasonic waves are transmitted to a uterine region of an object to be detected; ultrasonic echoes are received based on the ultrasonic waves reflected from the uterine region of said object, and ultrasonic echo signals are acquired on the basis of the ultrasonic echoes; the ultrasonic echo signals are processed to obtain three-dimensional data of the uterine region of said object; the endometrium is identified from the three-dimensional data of the uterine region according to endometrium image characteristics of the uterine region to obtain position information of the identified endometrium; according to the position information of the identified endometrium, the cross section of the identified endometrium is imaged on the basis of the three-dimensional data to obtain an cross-sectional endometrium image; and the cross-sectional endometrium image is displayed.

This invention discloses the application of ethinylestradiol and drospirenone in the preparation of drugs for treating post-traumatic stress disorder (PTSD). Ethinylestradiol, as an estrogen receptor agonist, regulates the hypothalamic-pituitary-gonadal axis and is used to treat female hypogonadism, menopausal syndrome, and advanced breast cancer, often in combination with progestins as oral contraceptives. The use of drospirenone and ethinylestradiol tablets (II) after induced abortion can shorten vaginal bleeding time, promote endometrial repair, and reduce the incidence of postoperative complications and repeat miscarriages. This invention has found that ethinylestradiol and drospirenone can reverse the abnormal decrease in hormones and neurosteroids caused by PTSD after spontaneous abortion, particularly the abnormal decrease in serotonin and tetrahydroprogesterone.

The invention relates to the field of human body sampling devices, and particularly discloses an artificial insemination and endometrium sampling device with a visual uterine cavity. The main pipeline and the auxiliary pipeline are arranged on the mounting head, the push-pull rod and the piston are arranged in the main pipeline, and the lens tube of the endoscope is inserted into the auxiliary pipeline through the inner curve of the mounting head, so that when the endometrium of a patient is finely sampled, a shot picture of the lens tube can be obtained through the endoscope; the main pipeline and the auxiliary pipeline are stretched into appropriate positions in the uterus according to images, then endometrium sampling operation is completed, when artificial insemination operation is carried out, images can be shot through a lens tube of an endoscope, the main pipeline and the auxiliary pipeline are stretched into appropriate positions in the vagina, and then the artificial insemination operation is completed. Endometrial sampling operation and artificial insemination operation are visually completed, and the efficiency of medical work can be effectively improved.

LNPs can penetrate uterine mucosa to deliver therapeutic or prophylactic agents such as functional nucleic acids to the endometrium. Targeting of the LNPs using ligands expressed at particular times in an endometrial cycle ensures that the LNPs penetrate and release the mRNA primarily to the tissue associated with the peak time period for implantation, thereby providing a means to address infertility, as well as for treatment of other disorders such as cancer.

The invention relates to the technical field of uterus image segmentation, in particular to a woman uterus disease auxiliary diagnosis and evaluation system based on magnetic resonance imaging. After a uterus image of a patient is obtained and a uterine cavity area is positioned, clustering clusters are divided according to pixel gray values by using a clustering algorithm to correspond to different uterus areas. And generating an endometrial region descriptor and screening out an endometrial region by combining the pixel number distribution of each region, the gray features and the shape difference between the endometrial region descriptor and the uterine cavity. Performing gray scale segmentation on the region to extract a high-signal region, and calculating an internal descriptor according to internal edge distribution and morphological characteristics of the high-signal region; meanwhile, an external descriptor is generated based on edge pixel neighborhood gray scale difference. And finally fusing internal and external descriptors to realize auxiliary diagnosis of uterine diseases. According to the method, the uterus image with obvious uterine cancer staging development tendency can be screened out, and a more accurate diagnosis effect is provided for related personnel.

This invention discloses an endometrial stem cell preparation and its application for cervical hypertrophy and cuticle repair, belonging to the field of stem cell technology. The endometrial stem cell preparation includes a stem cell gel carrier, endometrial stem cells, auxiliary repair peptides, and a survival enhancer. In the endometrial stem cell preparation, the stem cell gel carrier, endometrial stem cells, auxiliary repair peptides, and survival enhancer work synergistically to improve the survival rate of endometrial stem cells in vivo. The auxiliary repair peptides can activate the MAPK / ERK pathway of endometrial stem cells, and the anti-inflammatory mimic peptides in the survival enhancer can inhibit the stress silencing of endometrial stem cells, thereby ensuring the secretory function of endometrial stem cells. Furthermore, the three-dimensional porous structure of the stem cell gel carrier enhances the targeted repair ability of endometrial stem cells and enhances the homing and colonization of endometrial stem cells to cervical lesions.

The invention provides a uterine cavity treatment device, and belongs to the technical field of uterine cavity postoperative continuous treatment devices. The treatment device comprises a uterine cavity support and a conveying system, the uterine cavity support comprises a supporting framework and a medicine carrying covering film, a main body of the supporting framework is of a big-end-up three-dimensional cage-shaped structure, angle-shaped protrusions are symmetrically arranged on the left side and the right side of the far end of the supporting framework, and the angle-shaped protrusions obliquely extend upwards with the center of the uterine cavity support as the reference; an arc-shaped structure is formed, so that the whole shape of the supporting skeleton is matched with the uterus shape after the supporting skeleton is automatically expanded; the medicine carrying covering film is at least arranged on the outer side of the supporting framework; a hormone sustained-release drug is arranged in the drug-loading covering membrane and is used for promoting repair of endometrium; the conveying system is used for loading the uterine cavity stent in a contracted state and conveying the uterine cavity stent to a target position to complete release; the technical problem that in the prior art, the effect of treating intrauterine adhesion after an intrauterine operation is poor is mainly solved.

The application provides a trophoblast organ-on-chip system for simulating a maternal-fetal interface of a systemic lupus erythematosus model based on an organ chip and a construction method thereof, the system taking an organ chip as a carrier and comprising three core parts of a trophoblast organ, an endometrial chip and an SLE disease model. The application completes separation culture and characterization of the trophoblast organ, multi-cell co-culture construction and characterization of the endometrial chip, and then constructs a pathological model, and the three parts cooperatively form a three-dimensional maternal-fetal interface. The system can clearly observe the dynamic process of the trophoblast organ invading the endometrial chip, can detect the continuous secretion of hCG and SLE-related inflammatory factors, and breaks through the defects of the prior art model, such as low authenticity, inability to dynamically observe, single detection dimension and lack of standardization, and has both physiological and pathological adhesion and experimental repeatability, can multi-dimensionally characterize the cell phenotype and function of the maternal-fetal interface, and provides an in-vitro research platform for the pathological mechanism research of the SLE pregnancy-related abnormal maternal-fetal interface.

Embodiments of the present application provide a method for determining a region of interest in an ultrasound image and an ultrasound imaging device. The method comprises: acquiring a uterine ultrasound image and displaying the uterine ultrasound image via a display interface; determining first feature points of the endometrium in the uterine ultrasound image, the first feature points comprising a feature point located at the cervix and a feature point located at the fundus; automatically connecting the first feature points comprising the feature points of the cervix and the fundus according to the direction of the endometrium to form an endometrial boundary line of the endometrium; and determining the region in the uterine ultrasound image between at least the endometrial boundary lines as the region of interest. This application can improve the accuracy and efficiency of determining a region of interest that aligns with the endometrial / junctional zone morphology.

The present invention relates to dispensing instruments and methods for introducing treatment material and fluid-like material with an embryo into a uterus. More specifically, the present invention relates to apparatuses for delivering a fertilized egg or embryo into a maternal uterine endometrium in humans or any other mammalian species and associated computer programs for controlling said apparatuses.

An apparatus (100) suitable for delivering a fertilized egg or embryo into a maternal uterine endometrium in humans or any other mammalian species, comprising a body (110) configured to fit within a lumen of the female reproductive system. The body (110) comprises one or more lumens extending from a proximal end (130) of the body (110) to a distal portion of the body (110) and having a distal opening (150) at the distal portion of the body (110), wherein a first lumen (120) of the one or more lumens slidably receives an inner body (160) having a distal end suitable for penetrating the endometrial epithelium. The inner body (160) comprises an inner lumen for receiving a fertilized egg. An actuator (195) is operable to expel the fertilized egg from the inner lumen. A covering layer (170a) at least partially covers the distal opening of at least one lumen of the one or more lumens and at least partially covers the distal opening (150) of the first lumen (120) and the inner body (160) is configured to perforate through the covering layer (170a) when the inner body (160) is advanced out from the distal opening (150) of the body (110).

The present application relates to the field of traditional Chinese medicine, and specifically relates to a kind of external use traditional Chinese medicine composition for treating thin endometrium, which is composed of the following raw medicinal materials: cinnamon 250-300g, fennel 250-300g, Corydalis 250-480g, Cnidium 250-400g, safflower 250-300g, Evodia 150-200g, mugwort leaf 250-300g, and ginger juice 500-600ml.The external use combined medicine of the present application can obviously improve the symptoms of dysmenorrhea, little menstrual flow, dark red menstrual color, and more menstrual blood clots, thicken the endometrial thickness during ovulation, and improve the clinical pregnancy rate of patients with thin endometrium.The external use traditional Chinese medicine is absorbed through skin, does not burden liver and kidney functions, achieves the purposes of warming meridians, activating blood and resolving stasis through the action of acupoint meridian, has little side effects, and is convenient for promotion.

The present invention relates to dispensing instruments and methods for introducing treatment material and fluid-like material with an embryo into a uterus. More specifically, the present invention relates to apparatuses for delivering a fertilized egg or embryo into a maternal uterine endometrium in humans or any other mammalian species and associated computer programs for controlling said apparatuses.

The invention discloses an endometrial volume quantitative analysis system based on an ultrasonic imaging technology, and relates to the technical field of endometrial volume quantitative analysis, and the endometrial volume quantitative analysis system comprises the following steps: a data processing module, which is used for carrying out data processing on multi-modal ultrasonic data through a target detection algorithm and a signal processing algorithm to obtain a dual-channel data matrix; the feature optimization module is used for performing clustering analysis on the two-channel data matrix by adopting a clustering algorithm to obtain a blood vessel density feature vector and a blood flow intensity feature vector; the parameter optimization module is used for inputting the blood vessel density feature vector and the blood flow intensity feature vector into a multi-objective optimization model for optimization to obtain a blood flow space compensation coefficient; the fusion reconstruction module is used for performing compensation fusion on the multi-modal ultrasonic data based on the blood flow space compensation coefficient to obtain a quantitative volume optimization value, and the problem that the accuracy of endometrial volume calculation is reduced due to the contradiction between the factor endometrial volume measurement precision and the blood flow signal integrity in a traditional method is solved.

An elastic sheet for re-activating an endometrial basal layer in a uterine cavity comprises a silicone rubber and a drug, wherein the drug is encased inside the silicone rubber in the manner of a drug storage zone, or uniformly dispersed inside the silicone rubber, or carried by an outer surface of the silicone rubber as a coating, and the drug comprises an estrogen. A method for forming the elastic sheet with a drug in a matrix-type elastic sheet; or as a sustained release coating is provided. The estrogen is loaded on the silicone rubber, and thus the endometrial basal layer is continuously activated through drug stimulation, allowing for the endometrial basal layer to re-proliferate the functional layers, thereby restoring the normal endometrial structure and completely preventing adhesions.