123 results about "Uterine endometrium" patented technology

A pharmaceutical composition according to an aspect can be applied to the prevention, treatment or the like of endometrial damage, Asherman's syndrome, or complications thereof by: reducing the level of collagen accumulation in the endometrium; increasing the expression level of VEGF; increasing the expression level of Ki67; increasing the expression level of Itgb3; increasing the expression level of Spp1; increasing the number of implantation sites; decreasing the expression levels of fibrosis-related factors; decreasing the expression levels of metabolism-related factors; increasing ATP production; and regulating the expression levels of mitochondrial function-related factors.

The invention discloses a functional polypeptide for promoting repair of endometrial stem cells to clitoris sensitive nerves and application, and belongs to the technical field of stem cell repair, the functional polypeptide is used for modifying the endometrial stem cells and Schwann cells through the functional polypeptide, and the clitoris sensitive nerves are repaired in a local slow-release gel delivery mode. The functional polypeptide can activate Laminin expression and regulate and control ECM degradation balance, so that collagen deposition in scar tissues is reduced; in addition, the functional polypeptide can effectively inhibit HOXA1 expression, enhance the axon extension capacity and strengthen the axon microtubulin polymerization capacity of the nerve injury part, and the nerve repair efficiency and the function recovery quality are remarkably improved.

The invention relates to the technical field of medical gel, and particularly discloses a sustained-release gel preparation for endometrial repair and a preparation method of the sustained-release gel preparation. Keratinocyte factor sustained-release microspheres containing keratinocyte factor-glucan particles and lactic acid-glycolic acid copolymer shells are constructed around keratinocyte factors, and the keratinocyte factor sustained-release microspheres are loaded by hyaluronic acid hydrogel containing polylysine, collagen and silk fibroin to form the sustained-release gel preparation for endometrial repair. The sustained-release gel preparation has the effect of promoting proliferation of human endometrial cells, can repair endometrial injury, promote injury healing and prevent uterine cavity adhesion, and has important significance in treating endometrial injury and improving physical and psychological health of women.

The invention relates to the technical field of diagnosis of gynecological and obstetrical diseases, in particular to an endometrial disease onset risk prediction method and system. By combining multiple groups of indexes and image group feature data, the endometrium can be effectively evaluated, score data reflecting the tumor state of the endometrial disease can be obtained, and the incidence probability and the staging result degree of the endometrial disease can be more intuitively determined through the score data. Therefore, the overall automatic prediction of the endometrial disease is realized.

The invention relates to the technical field of biology, and particularly discloses a construction method and application of an endometrial epithelium organ fibrosis model. According to the method, human endometrial epithelial cells are extracted, and an endometrial epithelial organ is established by adopting a Matrigel three-dimensional culture system. Afterwards, the organoid is induced to form endometrial phenotypes in different physiological cycles through hormone stimulation, and a ferroptosis inducer FIN56 is added in the culture process to induce fibrosis. The expression of GPX4, Fibronectin and p-Smad2 / 3 is detected through Western blot and immunofluorescence, and the successful construction of the fibrosis model is verified. The invention provides an in-vitro model capable of simulating endometrial fibrosis pathological characteristics of a patient with PCOS (polycystic ovarian syndrome), the in-vitro model can be used for mechanism research and drug screening of PCOS-related endometrial lesions, and a new research tool and an intervention strategy are provided for treatment of PCOS endometrial fibrosis.

The invention relates to a lightweight yolov8-based endometritis classification and identification method and system, and the method comprises the steps: determining classified target historical hysteroscope image data, and enabling classification labels to comprise a normal classification group indicating normal endometrium and a lesion classification group indicating the existence of endometritis; dividing the target historical hysteroscope image data according to a preset distribution proportion to obtain training data and verification data; training data and verification data are input into a yolov8 classification model, in the training process, model lightweight processing is carried out based on weight importance pruning, quantification and knowledge distillation technologies, and feature weighting and selection based on an attention mechanism are carried out on target area features detected by yolov8 and related to endometrium and pre-acquired auxiliary modal features, so that the model weight is reduced; key feature information is extracted; and inputting real-time hysteroscope image data into the trained yov8 classification model to obtain an endometrial inflammation classification result for auxiliary diagnosis.

The invention relates to a pharmaceutical composition for treating uterine adhesion and application thereof. The kidney reinforcing and miscarriage preventing pills are used for improving endometrial blood perfusion and increasing the endometrial thickness, the kidney reinforcing and miscarriage preventing pills, aspirin and estrogen play a synergistic treatment role, the postoperative re-adhesion rate is remarkably reduced through combined treatment, and the fertility prognosis of a patient is improved; and the molecular mechanism of a TGF-beta1 pathway and EMT is deeply researched, and by inhibiting excessive activation of the TGF-beta1 signaling pathway, reducing endometrial fibrosis, regulating an epithelial-mesenchymal transition (EMT) process and promoting regeneration of endometrial epithelial cells, endometrial repair is further promoted, multi-target treatment is realized, and the treatment effect is remarkable. A brand-new and efficient treatment scheme is provided for treatment of intrauterine adhesion, an individualized treatment scheme can be formulated according to the specific conditions of patients, the treatment accuracy and effectiveness are improved, and important clinical significance and application value are achieved.

The invention relates to the technical field of medical care information processing, and discloses a traditional Chinese medicine prescription efficacy evaluation system for treating intrauterine adhesion, comprising: a data preprocessing module for acquiring endometrial dynamic response gray time sequence characteristic data before and after a subject takes a prescription; the phase analysis module is used for determining a phase deviation distribution coefficient according to the phase angle distribution of the gray scale data of the reference pixel and the response pixel; the frequency domain inversion module is used for constructing an energy transfer gain spectrum by calculating a power ratio and identifying a characteristic resonant frequency; the evaluation index output module is used for generating an evaluation index for evaluating the viscoelasticity improvement degree of the endometrial tissue according to the deviation value of the characteristic resonant frequency in combination with the variation of the phase deviation distribution coefficient. And the quantitative accuracy of evaluation is improved.

The invention relates to the technical field of medical artificial intelligence monitoring, and discloses an intelligent monitoring method and system for a perfusion curative effect of a thin endometrial rich microplate. The method comprises the following steps: standardizing and fusing multi-source monitoring data, constructing a derivative feature set reflecting a treatment coordination rule through cross-cycle feature derivation, and establishing a curative effect behavior coding library according to the derivative feature set. After the real-time data is subjected to standardization processing, frame-by-frame mode matching and similarity calculation are carried out on the real-time data and a coding library, a corresponding analysis path is activated according to a result, and a curative effect behavior fragment with a timestamp is generated. The segments are associated and aggregated to form a complete curative effect event chain, key turning points are marked, and finally a structured monitoring report and a decision signal are generated through multi-dimensional influence evaluation. According to the invention, the conversion from static parameter judgment to dynamic curative effect behavior intelligent analysis is realized, and the continuity, accuracy and early warning capability of treatment process monitoring are improved.

This invention discloses the application of ethinylestradiol and drospirenone in the preparation of drugs for treating post-traumatic stress disorder (PTSD). Ethinylestradiol, as an estrogen receptor agonist, regulates the hypothalamic-pituitary-gonadal axis and is used to treat female hypogonadism, menopausal syndrome, and advanced breast cancer, often in combination with progestins as oral contraceptives. The use of drospirenone and ethinylestradiol tablets (II) after induced abortion can shorten vaginal bleeding time, promote endometrial repair, and reduce the incidence of postoperative complications and repeat miscarriages. This invention has found that ethinylestradiol and drospirenone can reverse the abnormal decrease in hormones and neurosteroids caused by PTSD after spontaneous abortion, particularly the abnormal decrease in serotonin and tetrahydroprogesterone.

LNPs can penetrate uterine mucosa to deliver therapeutic or prophylactic agents such as functional nucleic acids to the endometrium. Targeting of the LNPs using ligands expressed at particular times in an endometrial cycle ensures that the LNPs penetrate and release the mRNA primarily to the tissue associated with the peak time period for implantation, thereby providing a means to address infertility, as well as for treatment of other disorders such as cancer.

The invention relates to the technical field of uterus image segmentation, in particular to a woman uterus disease auxiliary diagnosis and evaluation system based on magnetic resonance imaging. After a uterus image of a patient is obtained and a uterine cavity area is positioned, clustering clusters are divided according to pixel gray values by using a clustering algorithm to correspond to different uterus areas. And generating an endometrial region descriptor and screening out an endometrial region by combining the pixel number distribution of each region, the gray features and the shape difference between the endometrial region descriptor and the uterine cavity. Performing gray scale segmentation on the region to extract a high-signal region, and calculating an internal descriptor according to internal edge distribution and morphological characteristics of the high-signal region; meanwhile, an external descriptor is generated based on edge pixel neighborhood gray scale difference. And finally fusing internal and external descriptors to realize auxiliary diagnosis of uterine diseases. According to the method, the uterus image with obvious uterine cancer staging development tendency can be screened out, and a more accurate diagnosis effect is provided for related personnel.

This invention discloses an endometrial stem cell preparation and its application for cervical hypertrophy and cuticle repair, belonging to the field of stem cell technology. The endometrial stem cell preparation includes a stem cell gel carrier, endometrial stem cells, auxiliary repair peptides, and a survival enhancer. In the endometrial stem cell preparation, the stem cell gel carrier, endometrial stem cells, auxiliary repair peptides, and survival enhancer work synergistically to improve the survival rate of endometrial stem cells in vivo. The auxiliary repair peptides can activate the MAPK / ERK pathway of endometrial stem cells, and the anti-inflammatory mimic peptides in the survival enhancer can inhibit the stress silencing of endometrial stem cells, thereby ensuring the secretory function of endometrial stem cells. Furthermore, the three-dimensional porous structure of the stem cell gel carrier enhances the targeted repair ability of endometrial stem cells and enhances the homing and colonization of endometrial stem cells to cervical lesions.

The invention provides a uterine cavity treatment device, and belongs to the technical field of uterine cavity postoperative continuous treatment devices. The treatment device comprises a uterine cavity support and a conveying system, the uterine cavity support comprises a supporting framework and a medicine carrying covering film, a main body of the supporting framework is of a big-end-up three-dimensional cage-shaped structure, angle-shaped protrusions are symmetrically arranged on the left side and the right side of the far end of the supporting framework, and the angle-shaped protrusions obliquely extend upwards with the center of the uterine cavity support as the reference; an arc-shaped structure is formed, so that the whole shape of the supporting skeleton is matched with the uterus shape after the supporting skeleton is automatically expanded; the medicine carrying covering film is at least arranged on the outer side of the supporting framework; a hormone sustained-release drug is arranged in the drug-loading covering membrane and is used for promoting repair of endometrium; the conveying system is used for loading the uterine cavity stent in a contracted state and conveying the uterine cavity stent to a target position to complete release; the technical problem that in the prior art, the effect of treating intrauterine adhesion after an intrauterine operation is poor is mainly solved.

The application provides a trophoblast organ-on-chip system for simulating a maternal-fetal interface of a systemic lupus erythematosus model based on an organ chip and a construction method thereof, the system taking an organ chip as a carrier and comprising three core parts of a trophoblast organ, an endometrial chip and an SLE disease model. The application completes separation culture and characterization of the trophoblast organ, multi-cell co-culture construction and characterization of the endometrial chip, and then constructs a pathological model, and the three parts cooperatively form a three-dimensional maternal-fetal interface. The system can clearly observe the dynamic process of the trophoblast organ invading the endometrial chip, can detect the continuous secretion of hCG and SLE-related inflammatory factors, and breaks through the defects of the prior art model, such as low authenticity, inability to dynamically observe, single detection dimension and lack of standardization, and has both physiological and pathological adhesion and experimental repeatability, can multi-dimensionally characterize the cell phenotype and function of the maternal-fetal interface, and provides an in-vitro research platform for the pathological mechanism research of the SLE pregnancy-related abnormal maternal-fetal interface.

Embodiments of the present application provide a method for determining a region of interest in an ultrasound image and an ultrasound imaging device. The method comprises: acquiring a uterine ultrasound image and displaying the uterine ultrasound image via a display interface; determining first feature points of the endometrium in the uterine ultrasound image, the first feature points comprising a feature point located at the cervix and a feature point located at the fundus; automatically connecting the first feature points comprising the feature points of the cervix and the fundus according to the direction of the endometrium to form an endometrial boundary line of the endometrium; and determining the region in the uterine ultrasound image between at least the endometrial boundary lines as the region of interest. This application can improve the accuracy and efficiency of determining a region of interest that aligns with the endometrial / junctional zone morphology.

The present invention relates to dispensing instruments and methods for introducing treatment material and fluid-like material with an embryo into a uterus. More specifically, the present invention relates to apparatuses for delivering a fertilized egg or embryo into a maternal uterine endometrium in humans or any other mammalian species and associated computer programs for controlling said apparatuses.

An apparatus (100) suitable for delivering a fertilized egg or embryo into a maternal uterine endometrium in humans or any other mammalian species, comprising a body (110) configured to fit within a lumen of the female reproductive system. The body (110) comprises one or more lumens extending from a proximal end (130) of the body (110) to a distal portion of the body (110) and having a distal opening (150) at the distal portion of the body (110), wherein a first lumen (120) of the one or more lumens slidably receives an inner body (160) having a distal end suitable for penetrating the endometrial epithelium. The inner body (160) comprises an inner lumen for receiving a fertilized egg. An actuator (195) is operable to expel the fertilized egg from the inner lumen. A covering layer (170a) at least partially covers the distal opening of at least one lumen of the one or more lumens and at least partially covers the distal opening (150) of the first lumen (120) and the inner body (160) is configured to perforate through the covering layer (170a) when the inner body (160) is advanced out from the distal opening (150) of the body (110).

The present application relates to the field of traditional Chinese medicine, and specifically relates to a kind of external use traditional Chinese medicine composition for treating thin endometrium, which is composed of the following raw medicinal materials: cinnamon 250-300g, fennel 250-300g, Corydalis 250-480g, Cnidium 250-400g, safflower 250-300g, Evodia 150-200g, mugwort leaf 250-300g, and ginger juice 500-600ml.The external use combined medicine of the present application can obviously improve the symptoms of dysmenorrhea, little menstrual flow, dark red menstrual color, and more menstrual blood clots, thicken the endometrial thickness during ovulation, and improve the clinical pregnancy rate of patients with thin endometrium.The external use traditional Chinese medicine is absorbed through skin, does not burden liver and kidney functions, achieves the purposes of warming meridians, activating blood and resolving stasis through the action of acupoint meridian, has little side effects, and is convenient for promotion.

The invention discloses an endometrial volume quantitative analysis system based on an ultrasonic imaging technology, and relates to the technical field of endometrial volume quantitative analysis, and the endometrial volume quantitative analysis system comprises the following steps: a data processing module, which is used for carrying out data processing on multi-modal ultrasonic data through a target detection algorithm and a signal processing algorithm to obtain a dual-channel data matrix; the feature optimization module is used for performing clustering analysis on the two-channel data matrix by adopting a clustering algorithm to obtain a blood vessel density feature vector and a blood flow intensity feature vector; the parameter optimization module is used for inputting the blood vessel density feature vector and the blood flow intensity feature vector into a multi-objective optimization model for optimization to obtain a blood flow space compensation coefficient; the fusion reconstruction module is used for performing compensation fusion on the multi-modal ultrasonic data based on the blood flow space compensation coefficient to obtain a quantitative volume optimization value, and the problem that the accuracy of endometrial volume calculation is reduced due to the contradiction between the factor endometrial volume measurement precision and the blood flow signal integrity in a traditional method is solved.

An elastic sheet for re-activating an endometrial basal layer in a uterine cavity comprises a silicone rubber and a drug, wherein the drug is encased inside the silicone rubber in the manner of a drug storage zone, or uniformly dispersed inside the silicone rubber, or carried by an outer surface of the silicone rubber as a coating, and the drug comprises an estrogen. A method for forming the elastic sheet with a drug in a matrix-type elastic sheet; or as a sustained release coating is provided. The estrogen is loaded on the silicone rubber, and thus the endometrial basal layer is continuously activated through drug stimulation, allowing for the endometrial basal layer to re-proliferate the functional layers, thereby restoring the normal endometrial structure and completely preventing adhesions.

The invention discloses a convenient sampling device for endometrium detection of an intrauterine adhesion patient, and relates to the technical field of medical instruments. The aspirator is arranged in a round hole in the center of the mounting plate in a penetrating manner, a plurality of arc-shaped supporting plates are arranged on one side of the mounting plate at equal angles, and the arc-shaped supporting plates are connected with the mounting plate through supporting mechanisms; the connecting plates are symmetrically arranged on the two sides of the supporting plate front and back, and the upper sides of the connecting plates are connected with the mounting plate through angle adjusting mechanisms; the lifting mechanism is arranged in the supporting plate, the lifting mechanism is connected with the connecting plate, a sliding block is fixed to the lower side of the supporting plate, and the sliding block is arranged in a sliding groove in the bottom plate in a sliding and moving mode; the gear motor is embedded and fixed in one side of the bottom plate, a push screw rod is fixed on an output shaft of the gear motor, the push screw rod is screwed in the bottom plate through a bearing, and the push screw rod is screwed with the sliding block through a thread; the sampling angle and height can be automatically adjusted to adapt to different body positions, the arc-shaped supporting plate softly expands the uterine cavity, injuries are reduced, and the sampling safety and accuracy are improved.

The invention provides a suture line for manyule fixing and suturing, a fixing and suturing instrument and application, and belongs to the technical field of medical instruments. A circular ring is arranged at one end of the suture line, and more than one line knot is arranged on the suture line. The circular ring at the tail end of the suture is used for fixing the Munyun ring, so that the stimulation of the suture tail and the suture knot to the endometrium when the Munyun ring is connected through knotting and binding in the operation process is reduced, and the postoperative vaginal bleeding and bleeding are reduced. After the fixed stitching instrument is used for stitching a needle in the uterine cavity, the suture line is pulled until the line knot is embedded into the muscular layer or penetrates through the muscular layer to be fixed at a needle outlet point, so that the line knot plays a role in anchoring, and the Mune music is fixed in the uterine cavity. When the Munule is taken out, a hysteroscope operation is not needed again, and the Munule can be taken out only by clamping and pulling the Raman Munule ring according to a conventional method. When the suture is used for suturing and fixing Munule in an operation, the fixing effect is ensured, the operation time is shortened, the operation difficulty is reduced, the operation mode is simple and convenient, and the learning time of an operator is shortened.

The application provides an injectable hydrogel for endometrial repair and / or prevention of adhesion of uterine cavity and a preparation method and application thereof, and belongs to the technical field of biomedical materials. The injectable hydrogel is composed of a base gel and a decellularized matrix distributed in the base gel; the base gel is composed of a cross-linked carboxymethyl chitosan gel and a carbomer gel; the base gel has an interpenetrating or semi-interpenetrating double network structure; and the cross-linked carboxymethyl chitosan gel is a chemical cross-linked carboxymethyl chitosan gel. In the application, the injectable hydrogel forms a base gel with an interpenetrating or semi-interpenetrating double network structure by using a cross-linked carboxymethyl chitosan gel and a carbomer gel, and is compounded with a decellularized matrix, so that the injectable hydrogel has high elasticity and high adhesion, can effectively prevent adhesion and repair damaged tissues, has a long action time, and has good biocompatibility.

The embodiment of the invention provides an endometrium implanting device which comprises an implanting part, a balloon, a first sleeve and a second sleeve, and the implanting part comprises a near end and a far end which are oppositely arranged in the first direction; the balloon is arranged at the far end; the balloon is sleeved with the second sleeve, the second sleeve is sleeved with the first sleeve, and the side, away from the balloon, of the second sleeve and the first sleeve are arranged in a spaced mode to form a storage space used for containing a biological membrane. In the process that the implanter extends into the uterus, under the protection of the first sleeve, after the balloon and the biological membrane of the implanter enter the uterine cavity through the outer vagina and the cervix uteri, the first sleeve and the second sleeve move towards the near end direction to release the balloon and the biological membrane, and then the balloon and the biological membrane are released. The balloon is converted from the folded state to the expanded state so that the biological membrane can be unfolded and attached to the damaged area of the inner wall of the uterine cavity in a supporting and pressing mode, the biological membrane is tightly attached to the damaged tissue in the early stage of biological membrane implantation, non-invasive transplantation is achieved, and therefore the transplantation success rate of the biological membrane is increased.

The application discloses a preparation method of a 3D model of a maternal-fetal interface constructed by an endometrial organoid in vitro, and the method comprises the following steps: establishing a primary endometrial epithelial organoid and an endometrial stromal cell line in vitro; improving an extracellular matrix for assembling endometrial gland-like organoids and stromal cells; the constructed endometrial organoid model comprises gland cells and stromal cells; the endometrial organoid model is cultured by using a gas-liquid interface, so that the endometrial organoid model has a cavity epithelium and a gland structure; the endometrial organoid model simulates a menstrual cycle of the endometrium and performs function identification. The endometrial organoid model has the cavity epithelium and the gland epithelium for the first time, the tissue structure, the cell composition, the hormone-induced change, the gene expression characteristics of the organoid are similar to those in the body, and the organoid can reproduce the receptivity genes and the dynamicity of cilia which are necessary for embryo implantation in the body; the organoid can be used as a model for studying embryo implantation regulation, endometrial diseases and regeneration mechanisms.

1. The name of the design product: ultrasonic transducer. 2. The use of the design product: used for converting input electric energy into ultrasonic wave and emitting ultrasonic energy as one of the components of ultrasonic probe, cooperating with ultrasonic probe to realize ultrasonic examination, such as promoting postpartum lochia discharge, restoring uterus and its appendages to prepartum state, postabortion uterine involution, relieving pain including postpartum pain and dysmenorrhea, repairing endometrium and repairing scar. 3. The design points of the design product: in shape. 4. The picture or photo best indicating the design points: perspective view 1.

The present invention relates to a composition for endometrial regeneration containing a uterus-derived decellularized extracellular matrix (UdECM) and a manufacturing method therefor. Characterized by containing uterus-derived decellularized extracellular matrix (UdECM), the composition can exhibit the effect of enhancing the regeneration, receptivity, and implantation capabilities of the endometrium.

A device for endometrial ablation includes a selectively expandable bladder configured for insertion through a cervical canal of a patient and into a patient's cervix. The selectively expandable bladder defines an interior volume for receiving a thermally conductive medium which, when introduced into the interior volume, expands the selectively expandable bladder against the uterine tissue of the cervix. One or more insulative substrates is operably disposed within the interior volume and supports a thermal assembly on the one or more insulative substrates. The thermal assembly couples to an energy source and is configured to conduct thermal energy to a thermally conductive substrate upon activation of the thermal assembly, which, in turn, heats the thermally conductive medium in contact with the thermally conductive substrate to treat the uterine tissue of a patient.

The present application relates to the technical field of endoscopes. Disclosed are a drug release device and an endoscopic assembly. The drug release device comprises a first tube, a balloon and a light-emitting structure. The balloon is configured as a light-transmissive and expandable structure, and a structural layer of the balloon encloses an inner cavity, such that the inner cavity and the distal end of the first tube are sealed and are in communication with each other. Moreover, the first tube extends into the inner cavity, and then the light-emitting structure is provided in the balloon. Light emitted by the light-emitting structure and a photosensitive cross-linked drug composite layer located outside the structural layer are used to induce a cross-linking reaction. After the balloon is inserted into the uterus, a liquid can be injected into the balloon through the first tube so as to expand the balloon, and the expanded balloon can abut against the endometrium. After the light-emitting structure emits light, the photosensitive cross-linked drug composite layer can adhere to the surface of the endometrium, thereby enabling a drug contained in the photosensitive cross-linked drug composite layer to fully and tightly attach to the endometrium for the continuous treatment or repair of the endometrium.