Antiviral small nucleic acid and temperature-sensitive type gel preparation and application thereof

A temperature-sensitive, gel preparation technology, applied in the direction of antiviral, antitumor, aerosol delivery, etc., can solve the problem of not being able to effectively remove HPV-infected cervical precancer, the protection rate being less than 60%, and insufficient Eliminate problems such as viruses, and achieve the effects of high mechanical strength, convenient administration and enhanced stability
CN102899327AActive Publication Date: 2013-01-30YOUJIA (HANGZHOU) BIOMEDICAL TECH CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
YOUJIA (HANGZHOU) BIOMEDICAL TECH CO LTD
Publication Date
2013-01-30

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Abstract

The invention discloses an antiviral small nucleic acid and the application of the small nucleic acid in preparing a medicine for suppressing herpes simplex virus (HSV) and human papilloma virus (HPV). The small nucleic acid is a double strand nucleic acid, the positive-sense strand sequence is 5 in a sequence table, and the antisense strand sequence is 6 in the sequence table; the small nucleic acid can be prepared into a temperature-sensitive type gel preparation; the temperature-sensitive type gel preparation is injected (or sprayed) into irregular cavities such as vagina or mouth, the expression of host B2M genes in epithelial cells at the cavities and the cervix uteri and the expression of externalHPV E7 are suppressed, so that the antiviral small nucleic acid can be used for suppressing the infection of the HPV of the HSV-1 virus and / or for treating the precancerous lesions of uterine cervix caused by the HVP.
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Description

technical field

[0001] The invention relates to a small nucleic acid and its temperature-sensitive gel preparation and their application in preparing medicines for inhibiting diseases caused by herpes simplex virus (HSV) and human papillomavirus (HPV). Background technique

[0002] Herpes simplex virus (HSV) infection is a common cause of oral and genital herpes and ulcers. The population is generally susceptible to HSV. The infection rate of HSV-1 reaches about 80-90%, and the infection rate of HSV-2 is also as high as 22%-40%. HSV-1 mainly causes stomatitis and lip herpes, while HSV-2 is mostly transmitted through sexual activities and causes genital herpes. More and more studies have found that HSV-1 can also cause genital diseases, and it is more likely to cause genital diseases common cause. The virus can remain dormant in ganglia near the site of infection and remain virulent for life. Intermittent symptomatic activation causes distress to the patient, while asympto...

Claims

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