Oral biological macromolecular medicine administrating system based on biological adhesive microballoon

Abstract

The present invention provides one kind of biologically degradable adhesive natural polymer polysaccharide microballoon, its preparation, treating composition and medicine administrating system carrier. The microballoon is prepared by an oil-water two-phase process including dispersing pectin and xanthan gum in oil phase, adding chitosan and polycarbophil to graft, separation, cleaning and drying. It is biologically degradable and has good biocompatibility and strong biological adhesion. It is used in orally taken biological macromolecular medicine administrating system to raise the biological utilization of medicine.

Description

technical field

[0001] The invention relates to a biodegradable natural polymer polysaccharide bioadhesive microsphere, a preparation method of the microsphere, a therapeutic composition composed of the microsphere and a biomacromolecular therapeutic agent, and the bioadhesive microsphere The microsphere is used as a drug delivery system carrier to prepare an oral biomacromolecule drug delivery system. Background technique

[0002] The drug delivery and release system is a key link in the development and research of new drugs. How to ensure that the drug can maximize the curative effect shown in the in vitro experiment in the body, and at the same time minimize the toxic and side effects on other tissues, nerves, and organs of the body is an essential and important content in the development of new drugs.

[0003] With the rapid development of recombinant DNA technology, more and more polypeptide and protein drugs have emerged. For example, the global sales of erythropoieti...