385results about How to "Improve medicinal properties" patented technology

The invention discloses a quinolizinones compound which comprises an optical isomer, a raceme and a cis-trans-isomer and a random combination or pharmaceutical salt thereof. A structure of the quinolizinones compound is as shown in a formula I: (with reference to the specification), wherein one of V and Y is O, and the other one of V and Y is CR8R9; R8 and R9 respectively independently are hydrogen or C1-6 alkyl. The invention further discloses a preparation method and application of the compound in the formula I. The compound in the formula I can obviously reduce a HBsAg (Hepatitis B surface antigen) level in vivo and meanwhile, inhibit replication of a HBV (Hepatitis B Virus), wherein when V or Y is O, solubility of the compound is obviously improved, the compound has excellent medicinal attributes and meanwhile, is also low in toxicity, pharmacokinetics and pharmacodynamics functions are improved, efficiency of combining with the HBV can be greatly improved, and a clearance ratio of the HBV in vivo can also be further improved.

The invention discloses a Chinese medicinal composition for treating arthritis, osteoproliferation and disc protrusion, which comprises the following raw material constituents (by weight ratio): large-leaf gentian root, ledebouriella root, Ligusticum wallichii, Clematis chinensis, achyranthes and cyathula root, root of herbaceous peony, prepared rehmannia root, Chinese angelica root, eucommia bark, Cinnamomum cassia, wolferry fruit, morinda root, dipsacus root, poria cocos, Chinese ephedra, Loranthus mulberry mistletoe, cassia twig, corydalis tuber, notoginseng, notopterygium root, root of red rooted saliva, tetrandra root, spatholobus stem, dried orange peel, licorice root, pangolin scales, buthus martensi karsch, earthworm, wood louse, dragon's blood resin, wasp's nest and drynaria.

The invention discloses a salting-out and solvating-out crystallization method for citicoline. The method comprises the following steps: adding inorganic sodium salt which accounts for 1 to 20 percent of citicoline and a solvating agent which is 1.0 to 4.0 times the volume of a staring citicoline aqueous solution to a citicoline aqueous solution with a pH value between 5.0 and 8.0 and a concentration between 10 and 400 g/L; stirring the materials at a rotating speed controlled between 20 and 230 rpm at a temperature of between 10 and 40 DEG C; performing pumping filtration after complete crystallization; washing the obtained product with ethanol; drying the obtained product in vacuum; and obtaining the citicoline sodium salt crystals with the purity higher than 99 percent. The method has the advantages that the method obviously improves the quality of final products, raises crystallization yield stability, can control the particle size of the crystals by changing crystallization temperature or the states of a flow field, and is simple to operate, good in repeatability and suitable for the industrial production of the citicoline.

The invention discloses a Chinese medicinal composition, particularly a Chinese medicinal composition for treating femoral head necrosis and a preparation method thereof. The Chinese medicinal composition for treating the femoral head necrosis is characterized by comprising the following components: Chinese angelica, white paeony root, red paeony root, Szechuan lovage rhizome, manchurian wildginger, himalayan teasel root, eucommia bark, fortune's drynaria rhizome, twotooth achyranthes root, safflower, peach seed, suberect spatholobus stem, root of red-rooted salvia, rhizoma corydalis, worm, garden balsam stem, common clubmoss herb, pangolin scales, zedoary, dried rehmannia root, frank incense, myrrh, largehead atractylodes rhizome, astragalus, cuttlebone, trogopterus dung, sappan wood, dragon's blood and cornu cervi pantotrichum. The Chinese medicinal composition is specially used for treating femoral head avascular necrosis, femoral head damage, hip joint peripheral damage and necrosis, has an obvious curative effect and high medicinal properties, is used for treating both principal and secondary aspects of diseases, is safe and reliable, and has good effects of eliminating stasis and promoting tissue regeneration, cooling blood to stop bleeding, removing obstruction, smoothing circulation and stopping pain, easing joint movement, diminishing swelling and relieving pain, promoting tissue regeneration, promoting healing, and reuniting muscles and bones. By the Chinese medicinal composition, 860 patients are treated totally, and the total effective rate is 99 percent.

The invention provides a rhizoma polygonati planting method and application of same in plantation of polygonatum multiflorum. The method comprises the steps of selecting land and preparing soil, conducting treatment of the roots of rhizoma polygonati, planting, conducting water and fertilizer management in the later period, weeding and conducting pests management, and harvesting. The method changes the technical status quo of extensive plantation of rhizoma polygonati in the prior art, and provides a scientific, integrated and systematic technical scheme to the soil, base fertilizer, plant and root treatment in the planting process, the field management after the planting and other crucial factors. According to the polygonatum multiflorum planted by applying the method, the Rhizoma polygonati seedling can grow to the height of 120cm, the Rhizoma polygonati yield per mu increases by more than 4 times, and even as high as 10 times. As being tested, the Rhizoma polygonati planted by applying the method has a good drug property and a good anti-disease capability, a sugar content attaining more than 10 and even reaching as high as 12 with a good quality which far surpasses the sugar content standard of Rhizoma polygonati stipulated in Dictionary of Chinese Medicine. The method is suitable for large scale promotion and plantation, thus achieving the stable yield and high yield effect of Rhizoma polygonati plantation.

A crystallizing process for 5'-nucleoside-sodium phosphate includes such steps as proportionally adding the inorganic Na salt and solution educing agent, stirring while crystallizing at 15-40 deg.C, filtering, alcohol washing and vacuum drying. It has high output and controllable size of crystal.

The invention discloses a compound taking quinolizine ketone as a mother nucleus and for treating or preventing hepatitis B virus infection. The compound comprises optical isomer, raceme, cis-trans-isomer and any combination thereof or medicinal salt thereof. The invention further discloses a preparation method and application of the compound. The compound can remarkably lower in-vivo HBsAg leveland inhibit duplication of HBV, has good medicinal attribute and is low in toxicity, and pharmacokinetic and pharmacodynamic functions are improved; efficiency of combining with the HBV can be improved greatly, and clearance rate of in-vivo HBV can be further increased.

The invention discloses an organic fertilizer with insecticidal and sterilizing efficacy, and a preparation method thereof. The organic fertilizer comprises animal night soil, dead insects, waste vegetable fibers, soybean meal, animal bones, rice washed water, an EM inoculant, Bacillus subtilis, pomegranate rind extract, shaddock peel extract, Eomecon chionantha extract, Osbeckia chinensis L. extract and Rhodomyrtus tomentosa extract. The preparation method comprises the following steps: fermenting an organic fertilizer to prepare organic fertilizer powder, and mixing the organic fertilizer powder with traditional Chinese medicine extracts to obtain the organic fertilizer with insecticidal and sterilizing efficacy. The organic fertilizer with insecticidal and sterilizing efficacy, adopting the common action of the organic fertilizer powder and the traditional Chinese medicine extracts, provides comprehensive nutrient substances for crops, and reaches the insecticidal and sterilizing purposes in advance.

An antihypentenssive Chinese medicine for treating hypertension is prepared from 5 Chinese-medicinal materials including eucommia bark, motherwort, prunella spike, scutellaria root, etc through mixing and extracting.

The invention discloses 3-trifluoromethyl-5-tert-butoxycarbonyl-2,5-diheterobicyclo[2.2.1]heptane and a preparation method thereof. The invention mainly solves the technical problems that when a methyl derivative is introduced to the 3-site of the 2,5-diheterobicyclo[2.2.1]heptane compound, the synthesis steps are complicated, the water solubility is poor and the total yield is low. The structural formula of the compounds is shown as below, wherein R is NH or O; when R is NH, the compound is 3-trifluoromethyl-5-tert-butoxycarbonyl-2,5-diazabicyclo[2.2.1]heptane; and when R is O, the compound is 3-trifluoromethyl-5-tert-butoxycarbonyl-2-oxa-5-azabicyclo[2.2.1]heptane. The obtained compounds are mainly used to effectively connect the pharmacophore unit.

The invention discloses a centipede large-scale breeding technology and belongs to the field of breeding of special animals. The technical scheme adopted by the invention is as follows: in the breeding environments, the soil for centipede breeding needs to be loose and damp and have good heat-insulating and moisture-insulating properties; a layer of ginkgo leaves are put on the surface layer of the breeding soil; centipede is a typical carnivorous animal eating various living insects such as crickets, locusts, yellow meal worms, dragonflies, cockroaches, flies, bees and pupae and eggs thereof, as well as spiders, earthworms, snails, geckoes, snakes, frogs, birds and mice; and centipede can eat young leaves and buds of plants if necessary. The invention has the beneficial effects that the large-scale breeding of centipedes is achieved, the breeding speed is increased, the breeding stability is improved, the interference from external environments is eliminated and the input-to-output ratio is increased; the ginkgo leaves are adopted as the breeding ground for centipedes to achieve the purpose of keeping warm in winter and cooling in summer; the ginkgo leaves contain a variety of pharmaceutically-active components which can enhance the pharmaceutical effect of centipedes; the ginkgo leaves have an antimicrobial activity and can control diseases in centipedes during breeding so as to ensure the centipedes to be healthier.

The invention discloses a high-efficiency seedling spraying device. The high-efficiency seedling spraying device comprises a base, wherein supporting legs are fixedly connected to the two sides of the bottom of the base; roller wheels are movably connected to the bottoms of the supporting legs through rotating shafts; a pesticide box and a water pump are sequentially fixedly connected to the top of the base from the left side to the right side; a water collecting box is fixedly connected to the right side of the pesticide box; a water inlet pipe of the water pump is communicated with the bottom of the right side of the pesticide box; a water outlet pipe of the water pump is communicated with the bottom of the water collecting box; the front end and the back end of the right side of the water collecting box are communicated with short pipes; the right ends of the short pipes are communicated with soft pipes. Due to simultaneous working of two spray heads, a pesticide can be sprayed on both sides of the high-efficiency seedling spraying device at the same time; due to matching of a first motor, a first gear and second gears, vertical pipes can do forward and reverse rotation motions, and the vertical pipes drive the spray heads to do forward and reverse rotation motions, so that the spraying area of the spray heads is increased, the flexibility of the spray heads is improved, and the spraying efficiency is improved.

The invention relates to an Chinese medicinal oral liquid for treating iron-deficiency anemia, which is prepared from prepared fleece flower root, Chinese angelica root, astragalus root each 20-30g, pilose asiabell root, schisandra fruit, smoked plum, dried orange peel, poria cocos, radix salvia miltiorrhiza each 15-20g, prepared rhizome of rehmannia, wolfberry fruit each 10-15g and licorice root 10g.

The invention discloses a traditional Chinese medicine composition with an efficacy on lowering uric acid, and a preparation method and application thereof. The traditional Chinese medicine composition is prepared from 20-80 parts of poria cocos, 20-60 parts of coix seed, 5-20 parts of fructus gardeniae, 5-20 parts of peach kernel, 5-20 parts of fructus chaenomelis, 5-15 parts of rhizoma polygonati, 5-15 parts of herba lophatheri, 5-15 parts of licorice root, 2-20 parts of fructus lycii, 30-90 parts of radix puerariae, 20-60 parts of folium mori and 2-15 parts of radix ginseng. The compositiondisclosed by the invention has a scientific and reasonable formula, common medical and edible raw materials are selected, and the composition is proved to own an obvious uric acid lowering efficacy through an animal pharmacodynamic test and a clinical test, is safe and reliable, does not have toxic or side effect and is suitable for gout patients and high uric acid crowds to eat for a long time.

The invention relates to an asparagus extract bifidobacterium fermentation activity beverage and a preparation method thereof. An asparagus extract, brown sugar and stachyose serve as a culture medium; the following strains as shown in the specification are subjected to anaerobic fermentation to culture a bifidobacterium; after the anaerobic fermentation, a fermented probiotic liquid is subjected to sterile filling; and the bifidobacterium, lactobacillus plantarum, lactobacillus acidophilus and saccharomyces cerevisiae are freeze-dried bacteria bought from a culture collection center. The beverage supplements a specific bifidus factor and an exogenous bifidus factor in a plant in order to culture high-density bifidobacterium longum, increase the unit bacterial count of other lactic acid bacteria, conduct enzymolysis of small protein converting peptide in the culture medium, increase the content of amino acid essential for a human body, and improve the activity of asparagus juice, and a health care function of the whole fermentation liquid. The technology has the advantages that a strict anaerobic condition of the bifidobacterium is overcome, an expensive bifidobacterium fermentation device is removed, and the health care function of metabolic products of an active substance and a microorganism containing asparagus, as well as the fermentation liquid of the viable bacteria is enhanced.

The invention relates to a traditional Chinese medicine composition, particularly a traditional Chinese medicine composition for treating lumbar disc herniation and a preparation method thereof. The traditional Chinese medicine composition for treating lumbar disc herniation is prepared from angelica, radix clematidis, epimedium, mistletoe, radix achyranthis bidentatae, eucommia, spatholobus stem, prepared rhizoma cyperi, ginger processed pinellia, arisaema cum bile, ground beetle, muscardine silkworm, lumbricus, gerba pyrolae, rhizoma alismatis, club moss, corydalis tuber, himalayan teasel root, cibot rhizome, papaya, radix linderae, scorpion, frankincense, myrrh, asarum, pseudo-ginseng, rhizoma drynariae and pangolin. By properly compounding the multiple medicines, the mutually synergic or resisting effects are utilized to lower or eliminate the toxic and side effects of the medicines, reduce the untoward reaction and enhance the curative effect; the traditional Chinese medicine composition is safe for clinical application, does not stimulate the viscera when being taken orally, is convenient to make and take, ensures the cleanliness of the medicines, is easy for storage, has the advantages of obvious curative effect, many absorbable effective components and favorable drug effect taking, and can treat both the symptoms and root causes; and the total effective rate is up to 96%.

The invention relates to an Chinese medicinal oral liquid for chest health care, which is prepared from Chinese angelica root 10g, rhizome of Sichuan lovage 5g, prepared rhizome of rehmannia 15g, radix salvia miltiorrhiza 9g, white atractylodes rhizome 10g, poria cocos wolf 10g, honey-fried licorice root 5g and fresh ginger three tablets.

The invention provides a method for detecting motion trails of particles in the pulmonary alveoli. The method includes the steps of firstly conducting mesh modeling on the pulmonary alveoli according to geometric data of the pulmonary alveoli and establishing a pulmonary alveoli dynamic mesh model, secondly conducting air flow field simulation in the pulmonary alveoli dynamic mesh model and obtaining the speed of the air flow field, thirdly simulating the particles of the pulmonary alveoli according to the air flow field speed of the pulmonary alveoli and obtaining a particle numerical simulation model, and finally determining the motion trails of different particles in the pulmonary alveoli under different stress conditions in steady and unsteady air flow according to the particle numerical simulation model. According to the method, accuracy in obtaining the motion trails of the particles in the pulmonary alveoli is improved, and therefore the particle deposition law can be determined according to the motion trails of the particles with different sizes under different stress conditions, and the drug property of aerosols can be improved.

The patent relates to the domain of traditional Chinese medicine oral liquid for treating male overweight. The main raw material of oral liquid include 15g each of astragalus, menispermaceae, atractylodes macrocephala koidz, rhizoma chuanxiong and polygonum multiflorum and 30g each of alisma, raw hawthornfruit, miltiorrhiza, artemisia and buffalo horn, 10g epimedium brevicornum and 9g raw rhubarb etc as pure Chinese herbs. The oral liquid mainly treat male overweight, dropsy and so on, and it can improve immunity capability.

The invention discloses a planting method of polygonatum odoratum. The planting method includes the steps of 1), seedling selection, 2) land selection, 3), base fertilizer applying before transplanting, 4), seedling from late July to late August each year, 5), fertilizer applying, 6), watering, weeding and insect preventing, 7), harvesting in November next year. By reasonable base fertilizer and topdressing applying, reasonable field management and timely loosening, weeding and insect removing, leaf spot disease, root rot and purple wheel disease rarely occur, and the survival rate reaches more than 98%; the polygonatum odoratum planted in the method is good in quality, high in drug property and adaptability and suitable for large-area planting.

The invention discloses a dispersible oil suspended agent containing nicosulfuron, tembotrions and atrazine and a preparation method thereof, and belongs to the technical field of a pesticide. The dispersible oil suspended agent disclosed by the invention comprises nicosulfuron, tembotrions and atrazine; a mass ratio of nicosulfuron to tembotrions to atrazine is (1% to 20%):(1% to 20%):(1% to 50%); total mass percentage content of nicosulfuron, tembotrions and atrazine in the dispersible oil suspended agent is 3% to 90%. Firstly, an emulsifier, a dispersant, nicosulfuron, tembotrions and atrazine are added into a reaction kettle after being ground to a particle size of below 0.01cm, and are uniformly mixed and dispersed; a thickener is added in a high-speed shearing state, the mixture is ground to a particle size of below 5mu m, and then a stabilizer, plant oil and deionized water are added into the reaction kettle together and are uniformly mixed and dispersed to oibtain the dispersible oil suspended agent containing nicosulfuron, tembotrions and atrazine. The dispersible oil suspended agent containing nicosulfuron, tembotrions and atrazine, which is disclosed by the invention, has an obvious synergistic effect.

The invention discloses a fumigation device used for traditional Chinese medicine treatment for the gynecology department. The device comprises a bottom plate, a fumigation grove is fixedly connectedto the top of the bottom plate, and a motor box is fixedly connected to the portion, located on one side of the fumigation groove, of the top of the bottom plate; a first motor is fixedly connected tothe bottom of the inner wall of the motor box, a first belt wheel sleeves the outer surface of an output shaft of the first motor, and a first threaded rod is rotatably connected to one side of the inner wall of the motor box through a bearing; a second belt wheel sleeves the outer surface of the first threaded rod, and the outer surface of the second belt wheel is in transmission connection withthe outer surface of the first belt wheel through a belt. The invention relates to the technical field of fumigation devices used for traditional Chinese medicine treatment for the gynecology department. The fumigation device used for traditional Chinese medicine treatment for the gynecology department can conduct fumigation better on patients of the gynecology department, be good in fumigation effect, and improve the medicine property of traditional Chinese medicines to make the medicines exert effects better, and the practicability of the fumigation device is greatly improved.