Compound for treating or preventing hepatitis B virus infection and preparation method and application thereof

A technology of hepatitis B virus and compound, applied in the field of medicine, can solve the problem of inability to reduce the level of HBsAg

Active Publication Date: 2018-09-14
河南春风医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, currently commonly used antiviral drugs such as nucleoside (acid) analogues mainly function to inhibit the DNA synthesis of HBV, but cannot reduce the level of HBsAg in the body.

Method used

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  • Compound for treating or preventing hepatitis B virus infection and preparation method and application thereof
  • Compound for treating or preventing hepatitis B virus infection and preparation method and application thereof
  • Compound for treating or preventing hepatitis B virus infection and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0136] Embodiment 1 compound A (the compound of formula I)

[0137] Synthetic route of compound A

[0138]

[0139] During the preparation of compound A, specific conditions and operations can refer to similar reactions reported in patent documents US2016 / 0122344 A1 and CN105899508A.

Embodiment 2

[0140] Embodiment 2 Compound B (compound of formula III)

[0141] Synthetic route of compound B

[0142]

[0143]During the preparation of Compound B, specific conditions and operations can refer to similar reactions reported in patent documents US2016 / 0122344 A1 and CN105899508A.

Embodiment 3

[0144] Embodiment 3 compound C (the compound of formula IV)

[0145]

[0146] During the preparation of compound C, specific conditions and operations can refer to similar reactions reported in patent documents US2016 / 0122344 A1 and CN105899508A.

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PUM

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Abstract

The invention discloses a compound taking quinolizine ketone as a mother nucleus and for treating or preventing hepatitis B virus infection. The compound comprises optical isomer, raceme, cis-trans-isomer and any combination thereof or medicinal salt thereof. The invention further discloses a preparation method and application of the compound. The compound can remarkably lower in-vivo HBsAg leveland inhibit duplication of HBV, has good medicinal attribute and is low in toxicity, and pharmacokinetic and pharmacodynamic functions are improved; efficiency of combining with the HBV can be improved greatly, and clearance rate of in-vivo HBV can be further increased.

Description

[0001] The application of the present invention requires the title of "compounds for the treatment or prevention of hepatitis B virus infection and its preparation method and application", the application date is May 22, 2017, and the application number is 201710363808.X invention, as the invention in the present invention Compounds for treating or preventing hepatitis B virus infection, their preparation methods and applications. technical field [0002] The invention relates to the technical field of medicine, in particular to a quinozinone compound used for treating or preventing hepatitis B virus infection and its preparation method and application. Background technique [0003] As a partially double-stranded DNA virus, hepatitis B virus (HBV) needs to go through a step of reverse transcription from RNA intermediate to DNA for its replication. The HBV genome can encode a variety of antigens including surface antigen (HBsAg) and DNA polymerase required in the process of D...

Claims

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Application Information

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IPC IPC(8): C07D471/14C07D491/22C07D491/147C07D498/14C07D498/22A61P31/20
CPCA61P31/20C07D471/14C07D491/147C07D491/22C07D498/14C07D498/22
Inventor 李定芳李竞郭应臣
Owner 河南春风医药科技有限公司
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