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A medicament for treating cerebrovascular disease

A technology for cerebrovascular diseases and drugs, which is applied in the field of traditional Chinese medicine, can solve the problems of inconvenient injection, scutellarin not easy to pass through the blood-brain barrier, and limited curative effect, so as to improve the prevention and treatment effect and reduce the Sexual side effects, avoiding the effect of high risk of surgery

Inactive Publication Date: 2010-11-03
ZHEJIANG CHINESE MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the conventional route (gastrointestinal tract, intravenous) administration, scutellarin is not easy to penetrate the blood-brain barrier, the curative effect is limited, and most cerebrovascular diseases require long-term medication, injection administration is inconvenient, and the safety of traditional Chinese medicine injection is a problem. big problem

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Example 1 Preparation of solution (can be used as nasal drops, spray)

[0036] Breviscapine 1.0g

[0037] EDTA-2Na 0.1g

[0038] Sodium metabisulfite 0.15g

[0039] Benzalkonium Chloride 0.01g

[0040] pH7.5 Phosphate Buffer Add to 100ml

[0041] The above-mentioned components are prepared into nasal drops or nasal spray of breviscapine according to the conventional method.

Embodiment 2

[0042] Example 2 Preparation of gel (can be used as nasal drops, spray)

[0043] Breviscapine 1.0g

[0044] Carbopol 934PNF 0.5g

[0045] Sorbitol 4.0g

[0046] EDTA-2Na 0.1g

[0047] Sodium metabisulfite 0.15g

[0048] Benzalkonium Chloride 0.01g

[0049] Adjust pH to 6-7 with 1moI / L NaOH

[0050] Distilled water to 100ml

[0051] The above breviscapine, Carbopol 934PNF, sorbitol, EDTA-2Na, sodium metabisulfite and benzalkonium chloride were added to 50ml of distilled water, stirred magnetically for 24h, adjusted the pH to 6-7 with 1mol / L NaOH to form a gel, and added distilled water To 100ml light yellow gel.

Embodiment 3

[0052] Example 3 Preparation of powder

[0053] Breviscapine 1.0g

[0054] Lactose 30.0g

[0055] pH6.5-7.5 Phosphate Buffer 100ml

[0056] The above-mentioned breviscapine and lactose were added to 100ml of phosphate buffered saline, stirred until completely dissolved, freeze-dried at -35℃ overnight, then freeze-dried at -10℃ and 0℃ for 24h respectively, passed through a 180 mesh sieve, For nasal inhalation or spray.

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PUM

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Abstract

The invention discloses a medicament for treating cardiovascular and cerebrovascular diseases, which is prepared from original-shaped medicament of Breviscapine or its pharmaceutically acceptable salts as the active constituents. The medicament can be made into nasal preparation, wherein each 1g of the medicament contain 1-200mg of the active constituents

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine pharmacy, in particular to a medicine for treating cerebral infarction, migraine, vascular dementia and other cerebrovascular diseases. Background technique [0002] Cerebrovascular disease is a group of diseases that occur in the blood vessels of the brain and cause brain tissue damage due to intracranial blood circulation disorders. It is divided into ischemic cerebrovascular disease and hemorrhagic cerebrovascular disease. With the advent of an aging society in my country and changes in social life behavior and environmental factors, cerebrovascular disease is not only a major disease that endangers human health, but will be the "number one killer" of human death and disability in the next 20 years. [0003] However, due to the special anatomical structure and physiological importance of the brain, the application of surgery in the treatment of cerebrovas...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/28A61K31/7048A61K9/00A61P9/10A61P25/06A61P25/28
Inventor 石森林徐莲英储利胜李昌煜葛卫红吴瑾瑾沈炜张晓东毛展凯
Owner ZHEJIANG CHINESE MEDICAL UNIVERSITY
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