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Nasal liquid medicine for treating headache and its prepn process

A technology of liquid medicine and headache, which is applied in the field of nasal liquid medicine for the treatment of headache and its preparation, which can solve the problems of unfavorable absorption of medicinal active ingredients, low drug concentration, inconvenient use, etc., to cover bad smell and high drug concentration , increase the effect of drug absorption

Inactive Publication Date: 2007-06-06
成都厚发科技开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it is not only inconvenient to use, but also the concentration of the drug that can play a role is significantly low, and it is not conducive to the absorption of the active ingredients, and the safety of the drug is also relatively poor.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Put 160g of Angelica dahurica and 40g of Rhizoma Chuanxiong into a conventional steam distiller, add 8-12 times of distilled water, use an ordinary oil-water separator as a distillate collection device, and extract by steam distillation for 4-6 hours to obtain volatile oils of Angelica dahurica and Rhizoma Chuanxiong. Add 1.0ml Tween 80, 10ml propylene glycol, 15ml Transcutol  P and 10ml PEG 400, stir to dissolve, add distilled water to an appropriate amount, set aside. Take another 5 g of sodium carboxymethyl cellulose, add appropriate amount of distilled water and let it stand overnight, stir to dissolve. Combine the above two solutions, add distilled water to 100ml, stir well to obtain a clear and uniform solution, filter it, and distribute it in a special nasal drop bottle or spray bottle to obtain nasal drops or nasal spray.

Embodiment 2

[0020] Angelica dahurica and Chuanxiong were crushed through a 20-mesh sieve respectively, and 40kg of Angelica dahurica and 10kg of Chuanxiong were taken, mixed evenly, and supercritical fluid CO was used to 2 Circulating countercurrent extraction and separation, extraction pressure 10MPa, extraction temperature 35°C, extraction agent CO 2 The dosage is 400 kg / h, the extraction time is 4 hours, the desorption pressure of the separator is 5Mpa, and the desorption temperature is 30°C, and about 1.0 kg of the volatile oil extracts of Angelica dahurica and Chuanxiong are obtained. Take 200g of volatile oil extract, preheat to 55°C as the oil phase, and set aside; add 12g of soybean lecithin and 500ml of distilled water to disperse, add 24g of glycerin, 10g of tragacanth gum, 1g of ethyl paraben and appropriate amount of food flavor, stir to dissolve, Heat to 55°C and continue to stir, while slowly adding the oil phase, homogenize at high speed for 8 minutes to obtain colostrum, p...

Embodiment 3

[0022] Get 33.3kg of Angelica dahurica coarse powder and 16.7kg of Chuanxiong coarse powder, mix evenly, adopt supercritical fluid CO 2 Circulating countercurrent extraction and separation, extraction pressure 40MPa, extraction temperature 40°C, extraction agent CO 2 The dosage is 500 kg / h, the extraction time is 3 hours, the analytical pressure of the separator is 10Mpa, and the analytical temperature is 35°C to obtain 1.6kg of the volatile oil extracts of Angelica dahurica and Rhizoma Chuanxiong. Take 200g of volatile oil extract, add 6g of egg yolk lecithin as the oil phase; take 25g of glycerin, 1g of α-tocopherol, 1g of behenic acid, and 10g of carbomer dissolved in an appropriate amount of distilled water as the water phase. Heat to 55°C, mix well, first disperse and emulsify in a tissue masher for 3-4 minutes, then add distilled water to 1000ml, adjust the pH value to 6.0-7.0, and emulsify with a high-speed homogenizer until the oil droplet size is less than 5μm. Sub-p...

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PUM

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Abstract

The present invention is one kind of nasal liquid medicine for treating headache and its preparation process. The medicine consists of volatile dahurian angelica oil and volatile Chuanxiong oil as the effective medicine components and pharmaceutically acceptable supplementary material. The medicine is prepared into emulsion form or gel form, such as nasal drop, nasal spray, aerosol, nasal inhalant, etc. The volatile oil as the effective component is preferably extracted through supercritical CO2 circular extraction and separation. The medicine for treating headache has high bioavailability and excellent effect.

Description

technical field [0001] The present invention relates to a kind of medicament which takes the extract of natural medicinal raw material as active ingredient, more specifically a kind of nasal liquid medicament administered through nasal cavity, and a preparation method thereof. Background technique [0002] Migraine is a common and frequently-occurring disease in neurology, and the incidence rate is increasing year by year. Though the disease is not fatal, it seriously affects people's quality of life and normal work. According to reports, the economic loss caused by the disease in the United States alone is about 55 billion U.S. dollars per year. Western medicine does not have a unified understanding of the pathogenesis of migraine at present, and most agree that it is related to nervous system dysfunction. In traditional Chinese medicine, migraine belongs to the category of "head wind" disease, and it is believed that it is mostly caused by external attack of wind evil, a...

Claims

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Application Information

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IPC IPC(8): A61K36/236A61K9/00A61K9/107A61K9/12A61K9/72A61K47/44A61P25/04
Inventor 陈刚周家明杨秀清
Owner 成都厚发科技开发有限公司
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