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Curcumin microemulsion ion sensitive in situ gel preparation for intranasal administration and preparation method thereof

An ion-sensitive, in-situ gel technology, applied in the direction of anti-toxic agents, antipyretics, anti-inflammatory agents, etc., can solve the problems of affecting drug absorption and shortening drug residence time

Inactive Publication Date: 2012-08-22
SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the clearance of nasal cilia, the residence time of the drug in the nasal cavity is shortened, which affects the absorption of the drug.

Method used

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  • Curcumin microemulsion ion sensitive in situ gel preparation for intranasal administration and preparation method thereof
  • Curcumin microemulsion ion sensitive in situ gel preparation for intranasal administration and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Weigh 0.7g of Capryol 90, 4.0g of Cremophor EL, and 2.5g of Transcuol HP. After stirring evenly, add 600mg of curcumin. After stirring evenly, add 3g of 0.3% gellan gum solution dropwise and continue stirring.

Embodiment 2

[0022] Weigh 0.8g of Capryol 90, 5.0g of Solutol HS15, 2.5g of Transcuol HP, stir evenly, add 3g of 0.5% gellan gum solution dropwise, add 450mg of curcumin, and stir evenly to obtain.

Embodiment 3

[0024] Weigh 0.5 g of Capryol 90, 3.5 g of Solutol HS15, and 2.2 g of Transcuol HP. After stirring evenly, add 500 mg of curcumin. After stirring evenly, add 3.5 g of 0.3% gellan gum solution dropwise and continue stirring.

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Abstract

The invention discloses a curcumin microemulsion ion sensitive in situ gel preparation for intranasal administration, which uses curcumin as a raw medicine and adopts a surfactant, a cosurfactant, an oil phase and a gellan gum solution. According to the portions by weight, the preparation comprises 0.5-8 portions of curcumin, 4-25.6 portions of oil phase, 17-46.4 portions of surfactant, 17-46.4 portions of cosurfactant and 20-50 portions of gellan gum solution, wherein the mass concentration of the gellan gum solution is 0.1%-1.0%. The preparation method comprises the following steps of: firstly, uniformly mixing the oil phase, the surfactant and the cosurfactant in a mode of electromagnetic stirring, vortex oscillation or ultrasound; secondly, adding the curcumin, and fully stirring the mixture to be dissolved; thirdly, dropwise adding the gellan gum solution; and finally, continuously stirring the mixture to obtain the curcumin microemulsion ion sensitive in situ gel preparation for intranasal administration. After intranasal administration of the microemulsion ion sensitive in situ gel preparation disclosed by the invention, the medicine can reach brain targeted sites through a direct nose-brain path and a systemic circulation path, so that the curcumin has a treatment effect on brain tissues.

Description

[0001] technical field [0002] The invention relates to a curcumin microemulsion ion-sensitive in-situ gel preparation for nasal administration and a preparation method thereof. Background technique [0003] Curcumin (Curcumin, Cur) is from the genus Curcuma longa curcuma longa L. A natural phenolic compound extracted from plants, which has anti-inflammatory, anti-oxidant, antibacterial and other pharmacological effects, and can treat brain tumors, Alzheimer's disease, Parkinson's disease and other brain diseases. Curcumin has also entered the clinical research stage for the treatment of Alzheimer's disease. Due to the poor solubility of curcumin in water, the oral bioavailability is extremely low, only 1%. The curative effect of local diseases is an urgent problem to be solved. [0004] The method of transporting drugs to the brain through nasal administration has been paid more and more attention by researchers. The olfactory nerve is distributed in the olfactory area ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K9/107A61K31/12A61P25/28A61P25/16A61P25/00A61P35/00A61P29/00A61P39/06A61P31/04
Inventor 翟光喜王爽张林
Owner SHANDONG UNIV
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